公开(公告)号：US11192886B2

公开(公告)日：2021-12-07

申请号：US16319491

申请日：2017-07-21

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun Wu ,  Peng Zhang ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D409/04 ,  C07D513/04 ,  C07D487/04 ,  C07D209/58 ,  C07D417/14

摘要： The present invention relates to a class of tricyclic compounds and an application thereof as a sphingosine 1-phosphate type 1 (S1P1) receptor agonist. The invention specifically relates to a compound represented by formula (II), and a tautomer and pharmaceutically acceptable salt of same.

公开(公告)号：US11136315B2

公开(公告)日：2021-10-05

申请号：US16960468

申请日：2019-01-11

申请人： MEDSHINE DISCOVERY INC.

发明人： Bin Chen ,  Xiawei Wei ,  Xuefeng Sun ,  Lei Zhang ,  Zhaoying Xu ,  Wenli Li ,  Peng Zhang ,  Feng Gao ,  Yunfu Luo ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D405/12 ,  A61P11/00 ,  C07D211/54 ,  C07D215/38 ,  C07D277/64 ,  C07D307/81 ,  C07D333/52 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/048

摘要： A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

公开(公告)号：US10981900B2

公开(公告)日：2021-04-20

申请号：US16489476

申请日：2018-02-28

申请人： MEDSHINE DISCOVERY INC.

发明人： Peng Zhang ,  Lingyun Wu ,  Jun Yin ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D413/12 ,  C07D417/10 ,  C07D409/10 ,  C07F7/02 ,  C07D413/10 ,  C07D403/10

摘要： The present disclosure relates to a series of tricyclic compounds and the use thereof as receptor agonists of sphingosine-1-phosphate subtype 1 (S1P1), and in particular relates to compounds as shown in formula (I) or pharmaceutically acceptable salts thereof.