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公开(公告)号：US12018077B2
公开(公告)日：2024-06-25
申请号：US16912291
申请日：2020-06-25
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C07K14/705 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2803 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/3061 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/70
摘要： The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US10730941B2
公开(公告)日：2020-08-04
申请号：US15884608
申请日：2018-01-31
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61K35/17 , A61P35/00 , C07K16/30 , A61K39/00
摘要： The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US20240287543A1
公开(公告)日：2024-08-29
申请号：US18355575
申请日：2023-07-20
发明人： Michel Sadelain , Annalisa Cabriolu
CPC分类号： C12N15/86 , A61P7/00 , C12N9/22 , C12N2310/20 , C12N2830/008 , C12N2830/15 , C12N2830/30
摘要： The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
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公开(公告)号：US20240166743A1
公开(公告)日：2024-05-23
申请号：US18436160
申请日：2024-02-08
IPC分类号： C07K16/28 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783
CPC分类号： C07K16/2803 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70521 , C12N5/0636 , C07K2317/24 , C07K2317/53 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The presently disclosed subject matter provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to novel designs of chimeric antigen receptors (CARs) and engineered immunoresponsive cells comprising the same. The engineered immunoresponsive cells comprising the novel CARs are antigen-directed and have extended persistence without compromising function.
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公开(公告)号：US20230312706A1
公开(公告)日：2023-10-05
申请号：US18318588
申请日：2023-05-16
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , The U.S.A. as Represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/28 , C07K14/725 , C07K16/30 , C07K14/705 , C07K14/47
CPC分类号： C07K16/28 , C07K14/7051 , C07K16/30 , C07K14/705 , C07K14/70517 , C07K14/70521 , C07K14/4748 , A61K2039/505
摘要： The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US11717579B2
公开(公告)日：2023-08-08
申请号：US15449416
申请日：2017-03-03
发明人： Michel Sadelain , Isabelle Riviere , Jorge Mansilla-Soto , Xiuyan Wang , George Stamatoyannopoulos , John Stamatoyannopoulos , Mingdong Liu
CPC分类号： A61K48/0066 , A61K48/0058 , C07K14/805 , C12N9/22 , C12N15/85 , C12N15/86 , C12N2740/10043 , C12N2740/15043 , C12N2740/16043 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/40 , C12N2830/46 , C12N2830/48 , C12N2830/50
摘要： The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
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公开(公告)号：US20220401475A1
公开(公告)日：2022-12-22
申请号：US17405613
申请日：2021-08-18
发明人： Michel Sadelain , Mohamad Hamieh , Judith Feucht
IPC分类号： A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28
摘要： The presently disclosed subject matter provides methods and compositions for enhancing the immune response toward tumor and pathogen antigens. It relates to immunoresponsive cells comprising two or more chimeric antigen receptors (CARs), wherein the CARs comprise different intracellular signaling domains, in particular, the intracellular signaling domains of the CARs comprise different co-stimulatory molecules.
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公开(公告)号：US11193938B2
公开(公告)日：2021-12-07
申请号：US15966992
申请日：2018-04-30
发明人： Michel Sadelain , Fabiana Perna
IPC分类号： A61K35/17 , A61P35/00 , A61K48/00 , G01N33/574 , G16B5/00 , G16B20/00 , G16B30/00 , A61P35/02 , A61K39/00 , G01N33/569 , C07K14/705 , C07K14/715 , C07K16/00 , C07K14/72 , C07K14/47 , G16B20/30 , G16B20/20 , G16B20/50 , C07K16/28 , G01N33/566 , G01N33/68 , G06K9/00
摘要： The presently disclosed subject matter provides methods and compositions for treating myeloid disorders (e.g., acute myeloid leukemia (AML)). It relates to immunoresponsive cells bearing antigen recognizing receptors (e.g., chimeric antigen receptors (CARs)) targeting AML-specific antigens.
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公开(公告)号：US20200317781A1
公开(公告)日：2020-10-08
申请号：US16847059
申请日：2020-04-13
IPC分类号： C07K16/28 , C12N5/0783 , C07K14/705 , A61K39/00 , A61K35/17 , C07K14/725 , A61K35/15 , C07K16/30 , C12N9/24
摘要： The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
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公开(公告)号：US20200317777A1
公开(公告)日：2020-10-08
申请号：US16911148
申请日：2020-06-24
IPC分类号： C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783 , A61K35/17 , A61P35/00
摘要： The presently disclosed subject matter provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to novel designs of chimeric antigen receptors (CARs) and engineered immunoresponsive cells comprising the same. The engineered immunoresponsive cells comprising the novel CARs are antigen-directed and have extended persistence without compromising function.
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