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公开(公告)号：US20180230422A1
公开(公告)日：2018-08-16
申请号：US15952874
申请日：2018-04-13
Applicant: Merck Patent GmbH
Inventor： Joerg VON HAGEN , Marcel Andre BREUNING , Christian JASPER
CPC classification number: C12N5/0018 , C07F9/09 , C12N1/20 , C12N5/0025 , C12N2500/32 , C12N2500/33
Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
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2.发明申请SYNTHESIS OF 1-ALKYL-2-AMINO-IMIDAZOL-5-CARBOXYLIC ACID ESTER VIA CALPHA-SUBSTITUTED N-ALKYL-GLYCINE ESTER DERIVATIVES 审中-公开通过钙取代的N-烷基甘氨酸衍生物合成1-烷基-2-氨基咪唑-5-羧酸酯酯公开(公告)号：US20160251387A1
公开(公告)日：2016-09-01
申请号：US15028200
申请日：2014-10-10
Applicant: MERCK PATENT GMBH
Inventor： Christian JASPER , Helmut Dieter HAHN , Marcel Andre BREUNING , Philipp KRATTIGER , Michaela DEBOR
IPC: C07F9/6506 , C07D317/30
CPC classification number: C07F9/6506 , C07D317/12 , C07D317/30 , C07F9/222
Abstract: The invention provides an efficient and high yielding process for preparing TH-302, comprising at least one step wherein a dioxolane intermediate is generated in an aqueous layer, resulting in a synthesis that is amenable to scale up conditions.
Abstract translation: 本发明提供了一种制备TH-302的有效和高产率的方法，其包括至少一个步骤，其中二氧杂环戊烷中间体在水层中产生，得到可以扩大条件的合成。
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公开(公告)号：US20150337258A1
公开(公告)日：2015-11-26
申请号：US14442821
申请日：2013-11-14
Applicant: MERCK PATENT GMBH
Inventor： Joerg VON HAGEN , Marcel Andre BREUNING , Christian JASPER
CPC classification number: C12N5/0018 , C07F9/09 , C12N1/20 , C12N5/0025 , C12N2500/32 , C12N2500/33
Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
Abstract translation: 本发明涉及包含酪氨酸和/或半胱氨酸的无机酯衍生物的细胞培养基。 通过用无机酯衍生物代替它们来克服酪氨酸的不良溶解度和半胱氨酸在细胞培养基中通常不足够的稳定性。 与磷酸化衍生物。
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