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公开(公告)号：US20170240812A1
公开(公告)日：2017-08-24
申请号：US15519736
申请日：2015-09-17
Applicant: MERCK PATENT GMBH
Inventor： Christian JASPER , Timo UEBEL , Detlef PAULUTH , Michael JUNGE
CPC classification number: C09K19/54 , C07C25/18 , C09K19/12 , C09K19/3001 , C09K19/3003 , C09K2019/0448 , C09K2019/0466 , C09K2019/125
Abstract: The invention relates to substituted quinquephenyls of the formulae indicated in the claims and description. They are particularly suitable as UV-stabilising component in liquid-crystalline media.
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公开(公告)号：US20190100695A1
公开(公告)日：2019-04-04
申请号：US16087159
申请日：2017-03-22
Applicant: Merck Patent GmbH
Inventor： Atsutaka MANABE , Christian JASPER , Volker REIFFENRATH , Constanze BROCKE , Detlef PAULUTH , Dagmar KLASS , Renate SEEGER
Abstract: The present invention relates to liquid crystal mixtures comprising one or more compounds of the formula A and, in addition one or more compounds of formula I or one or more compounds of formula II wherein the individual radicals have the respective meanings indicated in claim 1, to the use thereof for high-frequency components, and to high-frequency components, in particular antennae, especially for the gigahertz range, comprising these media.
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公开(公告)号：US20170306230A1
公开(公告)日：2017-10-26
申请号：US15523609
申请日：2015-10-01
Applicant: MERCK PATENT GMBH
Inventor： Atsutaka MANABE , Christian JASPER , Volker REIFFENRATH , Constanze BROCKE , Detlef PAULUTH , Dagmar KLASS , Michael WITTEK , Renate SEEGER
CPC classification number: C09K19/3003 , C09K19/16 , C09K19/18 , C09K19/20 , C09K19/542 , C09K19/586 , C09K19/588 , C09K2019/0448 , C09K2019/0459 , C09K2019/0466 , C09K2019/123 , C09K2019/124 , C09K2019/163 , C09K2019/165 , C09K2019/166 , C09K2019/168 , C09K2019/183 , C09K2019/185 , C09K2019/3004 , C09K2019/3009 , C09K2019/3025 , C09K2219/11 , H01Q3/36 , H01Q21/06
Abstract: The present invention relates to liquid-crystalline media comprising—one or more compounds of formulae CC and/or CP and—one or more compounds selected from the group of compounds of formulae (I), (II) and (III), in which the parameters have the meaning indicated in Claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
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公开(公告)号：US20180155339A1
公开(公告)日：2018-06-07
申请号：US15528282
申请日：2015-11-17
Applicant: MERCK PATENT GMBH
Inventor： Andreas WAECHTLER , Hadia SALEH-KASSIM , Christian JASPER , Joern KOLB , David MAILLARD
IPC: C07D471/04 , C07B55/00 , C07B57/00 , C07C31/30
CPC classification number: C07D471/04 , C07B55/00 , C07B57/00 , C07B2200/07 , C07C31/30
Abstract: The present invention relates to a method for the racemization of enantiomerically pure or enantiomerically enriched Praziquantel under basic conditions and a method for the production of (R)-Praziquantel in enantiopure or enantiomerically enriched form, which comprises the racemization method.
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公开(公告)号：US20170362505A1
公开(公告)日：2017-12-21
申请号：US15691247
申请日：2017-08-30
Applicant: Merck Patent GmbH
Inventor： Christian JASPER , Constanze BROCKE , Detlef PAULUTH , Volker REIFFENRATH , Atsutaka MANABE
CPC classification number: C09K19/3059 , C07C331/08 , C09K19/08 , C09K19/10 , C09K19/12 , C09K19/18 , C09K19/322 , C09K2019/183 , C09K2219/11
Abstract: Compounds containing at least one C—C triple bond within a chain of at least 3 ring systems which have positive dielectric anisotropy, the use thereof for high-frequency components, liquid-crystalline media containing these compounds, and high-frequency components, in particular antennae, especially for the gigahertz region, containing these media. The liquid-crystalline media serve, for example, for the phase shifting of microwaves for tuneable phased-array antennae.
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Patent Agency Ranking
6.发明申请SYNTHESIS OF 1-ALKYL-2-AMINO-IMIDAZOL-5-CARBOXYLIC ACID ESTER VIA CALPHA-SUBSTITUTED N-ALKYL-GLYCINE ESTER DERIVATIVES 审中-公开通过钙取代的N-烷基甘氨酸衍生物合成1-烷基-2-氨基咪唑-5-羧酸酯酯公开(公告)号：US20160251387A1
公开(公告)日：2016-09-01
申请号：US15028200
申请日：2014-10-10
Applicant: MERCK PATENT GMBH
Inventor： Christian JASPER , Helmut Dieter HAHN , Marcel Andre BREUNING , Philipp KRATTIGER , Michaela DEBOR
IPC: C07F9/6506 , C07D317/30
CPC classification number: C07F9/6506 , C07D317/12 , C07D317/30 , C07F9/222
Abstract: The invention provides an efficient and high yielding process for preparing TH-302, comprising at least one step wherein a dioxolane intermediate is generated in an aqueous layer, resulting in a synthesis that is amenable to scale up conditions.
Abstract translation: 本发明提供了一种制备TH-302的有效和高产率的方法，其包括至少一个步骤，其中二氧杂环戊烷中间体在水层中产生，得到可以扩大条件的合成。
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公开(公告)号：US20180371320A1
公开(公告)日：2018-12-27
申请号：US15781602
申请日：2016-11-24
Applicant: MERCK PATENT GMBH
Inventor： Christian JASPER , Susann GUNST , Helmut HAENSEL , Brigitte SCHULER
Abstract: The invention relates to compounds of the formula I, in whichR, A, Z, m, L1, L2, L3 and X have the meanings indicated in Claim 1, to a process for the preparation thereof, and to liquid-crystalline media comprising at least one compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.
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公开(公告)号：US20170320873A1
公开(公告)日：2017-11-09
申请号：US15528116
申请日：2015-11-19
Applicant: Merck Patent GmbH
Inventor： David MAILLARD , Andreas WAECHTLER , Jeremy MAURIN , Ewgenij WAKARESKO , Christian JASPER
IPC: C07D471/04 , C07C59/84 , C07C59/64 , C07D217/14
CPC classification number: C07D471/04 , C07B2200/07 , C07C59/64 , C07C59/84 , C07D217/14
Abstract: The present invention relates to methods for the production of enantiopure or enantioenriched Praziquantel precursors and to methods for the production of enantiopure or enantioenriched Praziquantel comprising the methods for the production of the Praziquantel precursors. The present invention further relates to compounds or intermediates useful in such methods.
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公开(公告)号：US20150337258A1
公开(公告)日：2015-11-26
申请号：US14442821
申请日：2013-11-14
Applicant: MERCK PATENT GMBH
Inventor： Joerg VON HAGEN , Marcel Andre BREUNING , Christian JASPER
CPC classification number: C12N5/0018 , C07F9/09 , C12N1/20 , C12N5/0025 , C12N2500/32 , C12N2500/33
Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
Abstract translation: 本发明涉及包含酪氨酸和/或半胱氨酸的无机酯衍生物的细胞培养基。 通过用无机酯衍生物代替它们来克服酪氨酸的不良溶解度和半胱氨酸在细胞培养基中通常不足够的稳定性。 与磷酸化衍生物。
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公开(公告)号：US20190330530A1
公开(公告)日：2019-10-31
申请号：US16344463
申请日：2017-10-23
Applicant: Merck Patent GmbH
Inventor： Atsutaka MANABE , Christian JASPER , Volker REIFFENRATH , Constanze BROCKE , Detlef PAULUTH , Dagmar KLASS , Michael WITTEK , Renate SEEGER , Dmitry USHAKOV , Beate SCHNEIDER
Abstract: The present invention relates to liquid-crystalline media comprising one or more compounds of formula DFS in which the groups and parameters occurring have the meanings indicated in claim 1, to high-frequency components comprising same, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, in particular for microwave phased-array antennas. The present invention further relates to novel mesogenic compounds.
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