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公开(公告)号：US20160185726A1
公开(公告)日：2016-06-30
申请号：US14981847
申请日：2015-12-28
Applicant: MERIAL, INC.
Inventor： Charles Q. Meng , Alan Long , Scot Huber , Srinivas Reddy Gurrala , Douglas Edward Wilkinson , Gregory Pacofsky
IPC: C07D215/38 , A61K31/495 , A61K31/496 , C07D307/81 , C07C233/56 , A61K31/167 , C07D401/12 , C07D263/58 , C07D211/58 , C07D277/64 , C07D277/82 , C07D471/08 , C07D213/74 , C07D333/66 , C07D333/60 , A61K31/47 , A61K31/4995 , A61K31/472 , C07D295/16
CPC classification number: C07D215/38 , A61K31/167 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07C233/56 , C07C235/16 , C07C2601/14 , C07D211/58 , C07D213/74 , C07D215/42 , C07D217/06 , C07D241/04 , C07D263/58 , C07D277/64 , C07D277/82 , C07D295/15 , C07D295/16 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/81 , C07D307/82 , C07D333/60 , C07D333/66 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/08 , Y02A50/423
Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
Abstract translation: 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。
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公开(公告)号：US09249102B2
公开(公告)日：2016-02-02
申请号：US14083879
申请日：2013-11-19
Applicant: MERIAL INC.
Inventor： Charles Q. Meng , Alan Long , Srinivas Reddy Gurrala , Douglas Edward Wilkinson
IPC: A61K31/497 , C07D401/00 , C07D215/38 , A61K31/167 , A61K31/4704 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07D241/04 , C07D277/64 , C07D307/81 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/08 , C07D403/12 , C07D213/74 , C07D215/42 , C07D217/06 , C07D333/66 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D263/58 , C07D277/82 , C07D295/15 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/82 , C07C233/56 , C07C235/16
CPC classification number: C07D215/38 , A61K31/167 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07C233/56 , C07C235/16 , C07C2601/14 , C07D211/58 , C07D213/74 , C07D215/42 , C07D217/06 , C07D241/04 , C07D263/58 , C07D277/64 , C07D277/82 , C07D295/15 , C07D295/16 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/81 , C07D307/82 , C07D333/60 , C07D333/66 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/08
Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
Abstract translation: 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。
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Patent Agency Ranking
公开(公告)号：US20150183785A1
公开(公告)日：2015-07-02
申请号：US14658668
申请日：2015-03-16
Applicant: MERIAL, INC.
Inventor： Loic Patrick Le Hir de Fallois , Hyoung Ik Lee , Douglas Edward Wilkinson , Brent Christopher Beck
IPC: C07D471/04 , A01N43/90
CPC classification number: C07D471/04 , A01N43/80 , A01N43/90 , A61K31/365 , A61K31/437 , A61K31/495 , A61K38/05 , A61K45/06 , C07K5/06 , A61K2300/00
Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
Abstract translation: 本发明涉及式（I）的新型二氢唑及其盐：其中R1，A1，A2，G，X和Y如说明书中所定义，其组成，其制备方法及其用于预防或治疗寄生虫 感染或感染动物和农药。
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公开(公告)号：US09776999B2
公开(公告)日：2017-10-03
申请号：US15191163
申请日：2016-06-23
Applicant: MERIAL, INC.
Inventor： Loic Patrick Le Hir de Fallois , Hyoung Ik Lee , Douglas Edward Wilkinson , Brent Christopher Beck
IPC: A61K31/495 , A61K31/365 , C07D471/04 , A01N43/90 , A01N43/80 , A61K31/437 , A61K38/05 , A61K45/06 , C07K5/06
CPC classification number: C07D471/04 , A01N43/80 , A01N43/90 , A61K31/365 , A61K31/437 , A61K31/495 , A61K38/05 , A61K45/06 , C07K5/06 , A61K2300/00
Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
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公开(公告)号：US20170022197A1
公开(公告)日：2017-01-26
申请号：US15191163
申请日：2016-06-23
Applicant: MERIAL, INC.
Inventor： Loic Patrick Le Hir de Fallois , Hyoung Ik Lee , Douglas Edward Wilkinson , Brent Christopher Beck
IPC: C07D471/04 , A61K31/437 , A61K38/05 , C07K5/06 , A01N43/90
CPC classification number: C07D471/04 , A01N43/80 , A01N43/90 , A61K31/365 , A61K31/437 , A61K31/495 , A61K38/05 , A61K45/06 , C07K5/06 , A61K2300/00
Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
Abstract translation: 其中R1，A1，A2，G，X和Y如说明书中所定义，其组合物，其制备方法及其用于预防或治疗动物和农药中的寄生虫感染或侵染的用途。
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公开(公告)号：US10155725B2
公开(公告)日：2018-12-18
申请号：US14981847
申请日：2015-12-28
Applicant: MERIAL, INC.
Inventor： Charles Q. Meng , Alan Long , Scot Huber , Srinivas Reddy Gurrala , Douglas Edward Wilkinson , Gregory Pacofsky
IPC: A61K31/497 , C07D215/38 , A61K31/167 , A61K31/4704 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07D241/04 , C07D277/64 , C07D307/81 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/08 , C07D403/12 , C07D213/74 , C07D215/42 , C07D217/06 , C07D333/66 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D263/58 , C07D277/82 , C07D295/15 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/82 , C07C233/56 , C07C235/16 , A61K31/47 , A61K31/472 , C07D211/58 , C07D295/16 , C07D333/60
Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US09376434B2
公开(公告)日：2016-06-28
申请号：US14658668
申请日：2015-03-16
Applicant: MERIAL, INC.
Inventor： Loic Patrick Le Hir de Fallois , Hyoung Ik Lee , Douglas Edward Wilkinson , Brent Christopher Beck
IPC: A61K31/495 , A61K31/365 , C07D471/04 , A01N43/90 , A01N43/80 , A61K31/437 , A61K38/05 , A61K45/06 , C07K5/06
CPC classification number: C07D471/04 , A01N43/80 , A01N43/90 , A61K31/365 , A61K31/437 , A61K31/495 , A61K38/05 , A61K45/06 , C07K5/06 , A61K2300/00
Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
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