公开(公告)号：US20180068841A1

公开(公告)日：2018-03-08

申请号：US15560386

申请日：2016-03-29

Applicant: MERIDION, LLC

Inventor： Nicholas WILTON

IPC: H01J49/28 ,  H01J49/14 ,  H01J49/00 ,  H01J49/22 ,  H01J49/32 ,  H01J49/04

CPC classification number: H01J49/286 ,  H01J49/0027 ,  H01J49/0422 ,  H01J49/147 ,  H01J49/22 ,  H01J49/328

Abstract: Among other things, we describe methods and apparatus for the ionization of target molecular analytes of interest, e.g., for use in mass spectrometry. In some implementations, a thin molecular stream is emitted in either single or a split mode and encounters both an electron-impact ion source and trochoidal electron monochromator placed sequentially or coincidently. The first ion source emits high-energy electrons (˜70 eV) to generate characteristic positively-charged mass fragment spectra while the second source emits low-energy electrons in a narrow bandwidth to generate negative molecular ions or other ions via electron capture ionization. The dual ion source may be coupled to analytical instruments such as a gas chromatograph and to any number of mass analyzers such as a polarity switching quadrupole mass analyzer or to multiple mass analyzers.

公开(公告)号：US20190115201A1

公开(公告)日：2019-04-18

申请号：US16214566

申请日：2018-12-10

Applicant: MERIDION, LLC

Inventor： Nicholas WILTON

IPC: H01J49/28 ,  H01J49/32 ,  H01J49/22 ,  H01J49/14 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/286 ,  H01J49/0027 ,  H01J49/0422 ,  H01J49/147 ,  H01J49/22 ,  H01J49/328

Abstract: Among other things, we describe methods and apparatus for the ionization of target molecular analytes of interest, e.g., for use in mass spectrometry. In some implementations, a thin molecular stream is emitted in either single or a split mode and encounters both an electron-impact ion source and trochoidal electron monochromator placed sequentially or coincidentally. The first ion source emits high-energy electrons (˜70 eV) to generate characteristic positively-charged mass fragment spectra while the second source emits low-energy electrons in a narrow bandwidth to generate negative molecular ions or other ions via electron capture ionization. The dual ion source may be coupled to analytical instruments such as a gas chromatograph and to any number of mass analyzers such as a polarity switching quadrupole mass analyzer or to multiple mass analyzers.