公开(公告)号：US20170157266A1

公开(公告)日：2017-06-08

申请号：US15181028

申请日：2016-06-13

申请人： MOLECULAR EXPRESS, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Gary FUJII ,  Francis C. SZOKA, JR. ,  Douglas S. WATSON

IPC分类号： A61K9/127 ,  C12N7/00

CPC分类号： A61K47/6913 ,  A61K9/1272 ,  A61K39/07 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K47/543 ,  A61K47/554 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/60 ,  A61K2039/6018 ,  A61K2039/627 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/003 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2770/00011 ,  C12N2770/00034

摘要： The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

公开(公告)号：US20140308341A1

公开(公告)日：2014-10-16

申请号：US14320278

申请日：2014-06-30

申请人： MOLECULAR EXPRESS, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Gary FUJII ,  Francis C. SZOKA, JR. ,  Douglas S. WATSON

IPC分类号： A61K47/48 ,  C12N7/00 ,  A61K39/385

CPC分类号： A61K47/6913 ,  A61K9/1272 ,  A61K39/07 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K47/543 ,  A61K47/554 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/60 ,  A61K2039/6018 ,  A61K2039/627 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/003 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2770/00011 ,  C12N2770/00034

摘要： The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

摘要翻译： 本发明涉及脂质体疫苗组合物，其制备方法及其用于刺激动物免疫应答的方法。 这些组合物包含二肉豆蔻酰磷脂酰胆碱（“DMPC”）; 二肉豆蔻酰磷脂酰甘油（“DMPG”）或二肉豆蔻酰基三甲基铵丙烷（“DMTAP”）或DMPC和DMTAP两者; 和为一种或多种免疫原性多肽或碳水化合物提供共价锚的至少一种固醇衍生物。

公开(公告)号：US20180280534A1

公开(公告)日：2018-10-04

申请号：US15943382

申请日：2018-04-02

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  MOLECULAR EXPRESS, INC.

发明人： Gary FUJII ,  Francis C. SZOKA ,  Douglas S. WATSON

IPC分类号： A61K47/69 ,  A61K47/54 ,  A61K9/127 ,  A61K39/07 ,  A61K39/12 ,  C07J41/00 ,  A61K39/385 ,  C07J9/00 ,  C12N7/00 ,  C07J43/00 ,  A61K39/145 ,  A61K39/00

CPC分类号： A61K47/6913 ,  A61K9/1272 ,  A61K39/07 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K47/543 ,  A61K47/554 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/60 ,  A61K2039/6018 ,  A61K2039/627 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/003 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2770/00011 ,  C12N2770/00034

摘要： The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

公开(公告)号：US20210107862A1

公开(公告)日：2021-04-15

申请号：US17129712

申请日：2020-12-21

申请人： MOLECULAR EXPRESS, INC.

发明人： Kim JANDA ,  Sam ON HO ,  Gary FUJII

IPC分类号： C07C233/54 ,  A61P25/30 ,  A61K39/00 ,  A61K39/385

摘要： The present invention relates to vaccine compositions for treatment of substance use disorders, methods for the manufacture thereof, and methods for the use thereof to treat an animal. These compositions comprise a hapten conjugated via a linker to a protein scaffold and mixed with a particulate carrier and at least one immunostimulatory adjuvant molecule.