公开(公告)号：US10052377B2

公开(公告)日：2018-08-21

申请号：US15397214

申请日：2017-01-03

申请人： ADELAIDE RESEARCH & INNOVATION PTY LTD.

发明人： Eric James Gowans

IPC分类号： A61K35/12 ,  A61K39/29 ,  A61K31/711 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  A61K35/15 ,  A61K39/00

CPC分类号： A61K39/29 ,  A61K31/711 ,  A61K35/12 ,  A61K35/15 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/605 ,  A61K2039/6068 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/55 ,  C12N7/00 ,  C12N2740/16234 ,  C12N2770/00034 ,  C12N2770/24234 ,  A61K2300/00

摘要： The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein.

公开(公告)号：US20170106081A1

公开(公告)日：2017-04-20

申请号：US15397214

申请日：2017-01-03

申请人： ADELAIDE RESEARCH & INNOVATION PTY LTD.

发明人： Eric James Gowans

IPC分类号： A61K39/29 ,  A61K35/15 ,  A61K35/12 ,  A61K39/21 ,  C12N7/00

CPC分类号： A61K39/29 ,  A61K31/711 ,  A61K35/12 ,  A61K35/15 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/605 ,  A61K2039/6068 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/55 ,  C12N7/00 ,  C12N2740/16234 ,  C12N2770/00034 ,  C12N2770/24234 ,  A61K2300/00

摘要： The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein.

公开(公告)号：US20140335119A1

公开(公告)日：2014-11-13

申请号：US14286467

申请日：2014-05-23

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Assistance Publique Hopitaux de Paris

发明人： Vincent VIEILLARD ,  Patrice DEBRE

IPC分类号： A61K39/21 ,  C12N7/00 ,  C07K16/10

CPC分类号： A61K39/21 ,  A61K2039/57 ,  A61K2039/6081 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/1063 ,  C07K16/2803 ,  C07K2317/76 ,  C07K2317/92 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2770/00034 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/149

摘要： The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease. The invention also relates to immunological compounds and vaccine compositions comprising a polypeptide derived from gp41.

摘要翻译： 本发明涉及体外诊断患有属于人类免疫缺陷病毒（HIV）家族的病毒的个体的感染进展状态的领域以及该感染性疾病的治疗方法。 本发明还涉及包含衍生自gp41的多肽的免疫化合物和疫苗组合物。

公开(公告)号：US20170157266A1

公开(公告)日：2017-06-08

申请号：US15181028

申请日：2016-06-13

申请人： MOLECULAR EXPRESS, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Gary FUJII ,  Francis C. SZOKA, JR. ,  Douglas S. WATSON

IPC分类号： A61K9/127 ,  C12N7/00

CPC分类号： A61K47/6913 ,  A61K9/1272 ,  A61K39/07 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K47/543 ,  A61K47/554 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/60 ,  A61K2039/6018 ,  A61K2039/627 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/003 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2770/00011 ,  C12N2770/00034

摘要： The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

公开(公告)号：US20170128564A1

公开(公告)日：2017-05-11

申请号：US15360175

申请日：2016-11-23

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

发明人： Vincent VIEILLARD ,  Patrice DEBRE

IPC分类号： A61K39/21 ,  C07K16/10

CPC分类号： A61K39/21 ,  A61K2039/57 ,  A61K2039/6081 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/1063 ,  C07K16/2803 ,  C07K2317/76 ,  C07K2317/92 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2770/00034 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/149

摘要： The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease. The invention also relates to immunological compounds and vaccine compositions comprising a polypeptide derived from gp41.

公开(公告)号：US20140370051A1

公开(公告)日：2014-12-18

申请号：US14344360

申请日：2012-09-12

申请人： BOE TECHNOLOGY GROUP CO., LTD. ,  CHENGDU BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.

发明人： Yahia Chebloune ,  Delphine Aldebert ,  Géraldine Arrode-Bruses

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/15043 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16334 ,  C12N2770/00021 ,  C12N2770/00034

摘要： Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5′ and 3′ long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.

摘要翻译： 新型核酸包括非综合嵌合逆转录病毒基因组，包括山羊慢病毒的5'和3'长末端重复序列（LTR）：山羊关节炎脑炎病毒（CAEV）或不整合人细胞和至少一种病毒的另一种逆转录病毒 另一种逆转录病毒的基因。 还描述了包含这种核酸的载体，包含载体或核酸的免疫原性或疫苗组合物，以及其用于治疗和/或预防逆转录病毒感染或病原体诱导的疾病的用途。

公开(公告)号：US08765171B2

公开(公告)日：2014-07-01

申请号：US12720592

申请日：2010-03-09

申请人： Gary Fujii ,  Francis C. Szoka, Jr. ,  Douglas S. Watson

发明人： Gary Fujii ,  Francis C. Szoka, Jr. ,  Douglas S. Watson

IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K39/385 ,  C07J9/00 ,  A61P37/04

CPC分类号： A61K47/6913 ,  A61K9/1272 ,  A61K39/07 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K47/543 ,  A61K47/554 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/60 ,  A61K2039/6018 ,  A61K2039/627 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/003 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2770/00011 ,  C12N2770/00034

摘要： The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

摘要翻译： 本发明涉及脂质体疫苗组合物，其制备方法及其用于刺激动物免疫应答的方法。 这些组合物包含二肉豆蔻酰磷脂酰胆碱（“DMPC”）; 二肉豆蔻酰磷脂酰甘油（“DMPG”）或二肉豆蔻酰基三甲基铵丙烷（“DMTAP”）或DMPC和DMTAP两者; 和为一种或多种免疫原性多肽或碳水化合物提供共价锚的至少一种固醇衍生物。

公开(公告)号：US20130219556A1

公开(公告)日：2013-08-22

申请号：US13761845

申请日：2013-02-07

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

发明人： William O. Dawson ,  Svetlana Y. Folimonova

IPC分类号： C12N15/82

CPC分类号： C12N15/8203 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/00034 ,  C12N2770/00043

摘要： Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically exemplified herein are vectors for transfecting citrus trees. The vectors allow for the expression of useful proteins, such as those that can protect the tree from disease. Specifically exemplified herein are methods of transfecting woody trees that allow multiple applications of vectors while avoiding superinfection exclusion.

摘要翻译： 本文公开了适于转染木本树的病毒载体，用于递送和表达有益基因。 本文具体举例说明用于转染柑橘树的载体。 载体允许表达有用的蛋白质，例如可以保护树免于疾病的蛋白质。 具体举例说明的是转染木本树的方法，其允许多次施用载体同时避免超感染排除。

公开(公告)号：US20180133304A1

公开(公告)日：2018-05-17

申请号：US15589677

申请日：2017-05-08

申请人： Case Western Reserve University

发明人： Nicole F. Steinmetz ,  Amy M. Wen ,  Steven Fiering ,  Patrick H. Lizotte

IPC分类号： A61K39/12 ,  A61P35/00 ,  A61P35/04 ,  A61K31/704

CPC分类号： A61K39/12 ,  A61K31/704 ,  A61K2039/5258 ,  A61K2039/544 ,  A61K2039/585 ,  A61P35/00 ,  A61P35/04 ,  C12N7/00 ,  C12N2770/00023 ,  C12N2770/00034 ,  C12N2770/00071 ,  C12N2770/32022 ,  C12N2770/32023 ,  C12N2770/32034 ,  C12N2770/32071

摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

公开(公告)号：US09879230B2

公开(公告)日：2018-01-30

申请号：US14344360

申请日：2012-09-12

申请人： Yahia Chebloune ,  Delphine Aldebert ,  Géraldine Arrode-Bruses

发明人： Yahia Chebloune ,  Delphine Aldebert ,  Géraldine Arrode-Bruses

IPC分类号： A61K39/21 ,  C12N7/00 ,  C12N15/86

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/15043 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16334 ,  C12N2770/00021 ,  C12N2770/00034

摘要： Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5′ and 3′ long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.