公开(公告)号：US20180056086A1

公开(公告)日：2018-03-01

申请号：US15558588

申请日：2016-03-17

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Emanuel HARARI

IPC: A61N5/06 ,  A61B17/22 ,  A61M25/10

CPC classification number: A61N5/062 ,  A61B17/22031 ,  A61B2017/22002 ,  A61B2017/22051 ,  A61B2017/22087 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61M25/104 ,  A61M2025/105 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0643 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/067

Abstract: Aspects of disclosed embodiments relate to systems, devices and methods for treating and preventing restenosis by cross-linking collagen fibrils of the vessel wall at the intervention site. The devices described are drug-eluting devices comprising: an expandable member or a balloon; a cross-linking agent; and a photoactivating light source. Upon the inflation of the expandable member or the balloon the cross linking agent is released and photoactivated in a therapeutically effective amount for cross-linking collagen fibrils.