公开(公告)号：US20170281702A1

公开(公告)日：2017-10-05

申请号：US15089687

申请日：2016-04-04

Applicant: Macau University of Science and Technology

Inventor： Jing-Rong Wang ,  Zhi-Hong Jiang ,  Qi-Tong Feng ,  Guo-Yuan Zhu ,  Wei-Na Gao ,  Zifeng Yang ,  Nanshan Zhong

IPC: A61K36/19 ,  A61K31/7056 ,  A61K31/192 ,  A61K31/404 ,  A61K31/047 ,  A61K31/191 ,  A61K31/538 ,  A61K31/517

CPC classification number: A61K36/19 ,  A61K31/404 ,  A61K31/538 ,  A61K31/567 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/55

Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.

公开(公告)号：US10537601B2

公开(公告)日：2020-01-21

申请号：US15089687

申请日：2016-04-04

Applicant: Macau University of Science and Technology

Inventor： Jing-Rong Wang ,  Zhi-Hong Jiang ,  Qi-Tong Feng ,  Guo-Yuan Zhu ,  Wei-Na Gao ,  Zifeng Yang ,  Nanshan Zhong

IPC: A61K36/19 ,  A61K31/47 ,  A61K31/191 ,  A61K31/192 ,  A61K31/404 ,  A61K31/517 ,  A61K31/538 ,  A61K31/7056 ,  A61K31/567

Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.