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公开(公告)号：US10058573B1
公开(公告)日：2018-08-28
申请号：US15834017
申请日：2017-12-06
IPC分类号： A01N63/00 , A01N65/00 , C12N5/071 , A61K35/28 , A61K31/4427 , A61P37/00 , C12N5/0789 , A61K45/06 , A61K35/12
CPC分类号： A61K35/28 , A61K31/4427 , A61K45/06 , A61K2035/124 , A61P37/00 , C12N5/0647
摘要： Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the composition and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
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公开(公告)号：US20220401481A1
公开(公告)日：2022-12-22
申请号：US17773422
申请日：2020-10-30
发明人： Anthony Boitano , Michael P. Cooke , John C. Davis , Patrick C. Falahee , Kevin A. Goncalves , Sharon Hyzy , Dwight Morrow , Jason Neale , Glen Raffel , William Savage , Veit Schmelmer
IPC分类号： A61K35/17 , A61K31/395 , A61K35/15 , A61K35/28 , A61K38/19 , C12N5/0789
摘要： The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
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3.发明公开公开(公告)号：US20230330185A1
公开(公告)日：2023-10-19
申请号：US17921593
申请日：2021-04-27
发明人： Anthony Boitano , Kevin A. Goncalves , Dwight Morrow , Andre Lieber , Hans-Peter Kiem , Michael P. Cooke
IPC分类号： A61K38/19 , A61K38/46 , A61K31/7088 , A61K31/395 , A61K31/52 , A61K31/17 , A61K31/495 , A61K48/00 , A61P7/06 , A61K38/48 , A61K38/17 , A61K38/47 , A61K38/50 , A61K38/42 , A61K38/45 , A61K38/20
CPC分类号： A61K38/195 , A61K38/465 , A61K31/7088 , A61K31/395 , A61K31/52 , A61K31/17 , A61K31/495 , A61K48/0041 , A61P7/06 , A61K38/4846 , A61K38/1793 , A61K38/1774 , A61K38/47 , A61K38/50 , A61K38/42 , A61K38/45 , A61K38/2026 , A61K38/2066 , A61K38/2086
摘要： The invention relates to the in vivo transduction of hematopoietic stem and progenitor cells (HSPCs) in a subject, such as a human subject, and to the treatment of subjects suffering from various pathologies, such as blood diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
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公开(公告)号：US11260079B2
公开(公告)日：2022-03-01
申请号：US16352578
申请日：2019-03-13
IPC分类号： A61K35/28 , A61P37/00 , A61K45/06 , A61K31/4427 , A61K35/12 , C12N5/0789
摘要： The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.
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公开(公告)号：US20230130646A1
公开(公告)日：2023-04-27
申请号：US17743097
申请日：2022-05-12
IPC分类号： A61K35/28 , A61K31/4427 , A61P37/00 , C12N5/0789 , A61K45/06
摘要： Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the composition and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
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公开(公告)号：US20220096559A1
公开(公告)日：2022-03-31
申请号：US17314581
申请日：2021-05-07
IPC分类号： A61K35/28 , A61P37/00 , A61K45/06 , C12N5/0789 , A61K31/4427
摘要： The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.
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公开(公告)号：US20190336536A1
公开(公告)日：2019-11-07
申请号：US16212497
申请日：2018-12-06
IPC分类号： A61K35/28 , A61P37/00 , A61K31/4427 , A61K45/06 , C12N5/0789
摘要： The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.
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公开(公告)号：US20190167726A1
公开(公告)日：2019-06-06
申请号：US16101676
申请日：2018-08-13
IPC分类号： A61K35/28 , A61P37/00 , A61K31/4427 , A61K45/06 , C12N5/0789
摘要： Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the composition and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
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