公开(公告)号：US20080003681A1

公开(公告)日：2008-01-03

申请号：US11478316

申请日：2006-06-28

申请人： Mahalaxmi Gita Bangera ,  Leroy E. Hood ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Elizabeth A. Sweeney ,  Lowell L. Wood ,  Victoria Y.H. Wood

发明人： Mahalaxmi Gita Bangera ,  Leroy E. Hood ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Elizabeth A. Sweeney ,  Lowell L. Wood ,  Victoria Y.H. Wood

IPC分类号： C12N15/00 ,  C12N5/06

CPC分类号： C07K14/7158 ,  C12N2510/00

摘要： Methods as described herein relate to altering the potential infectivity of a cell or cells. Included are methods for altering DNA of non-terminally differentiated cells in locations that inhibit the function of at least one CCR5 gene relative to an unaltered version of the gene and providing stimulus for differentiation of the altered cell.

摘要翻译： 本文所述的方法涉及改变细胞或细胞的潜在感染性。 包括用于在相对于未改变的基因版本抑制至少一种CCR5基因的功能的位置中改变非终末分化细胞的DNA的方法，并为改变的细胞的分化提供刺激。

公开(公告)号：US20090024114A1

公开(公告)日：2009-01-22

申请号：US12229504

申请日：2008-08-22

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61K9/22

CPC分类号： A61K9/0004 ,  A61K9/0009 ,  A61K9/0024 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36 ,  A61N1/08

摘要： Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

公开(公告)号：US20120271228A1

公开(公告)日：2012-10-25

申请号：US13538895

申请日：2012-06-29

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M5/168 ,  B65D83/00

CPC分类号： A61K9/0009 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/172 ,  A61M5/1723 ,  A61M31/002 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36

摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

摘要翻译： 描述了包括远程控制物质输送装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，输送装置或相关装置可以放置在环境中，以便将材料泵入环境或装置内的附加流体处理结构。 示例性环境包括生物体，水体或封闭体积的流体。 被输送流体中物质的浓度可以通过遥控信号来改变。 在所选择的实施例中，可以使用磁场，电场或电磁控制信号。

公开(公告)号：US20090054877A1

公开(公告)日：2009-02-26

申请号：US12217873

申请日：2008-07-08

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61K9/22

CPC分类号： A61M5/14276 ,  A61M5/145 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36

摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.

公开(公告)号：US20090005727A1

公开(公告)日：2009-01-01

申请号：US12217872

申请日：2008-07-08

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M1/00

CPC分类号： A61M37/0092

摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.

摘要翻译： 描述了包括远程控制物质输送装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，输送装置或相关装置可以放置在环境中以便将材料泵入环境或装置内的附加流体处理结构。 示例性环境包括生物体，水体或封闭体积的流体。 被输送流体中物质的浓度可以通过遥控信号来改变。 在所选择的实施例中，可以使用声控制信号。

公开(公告)号：US20100030185A1

公开(公告)日：2010-02-04

申请号：US12587222

申请日：2009-10-01

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M31/00 ,  H04Q5/22 ,  G05D7/06 ,  G05D9/12 ,  G05D23/19

CPC分类号： A61M5/14276 ,  A61M2005/14513 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2205/3569 ,  G05D7/0623 ,  G05D23/1917

摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

摘要翻译： 描述了包括远程控制物质输送装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，输送装置或相关装置可以放置在环境中，以便将材料泵入环境或装置内的附加流体处理结构。 示例性环境包括生物体，水体或封闭体积的流体。 被输送流体中物质的浓度可以通过遥控信号来改变。 在所选择的实施例中，可以使用磁场，电场或电磁控制信号。

公开(公告)号：US20090162250A1

公开(公告)日：2009-06-25

申请号：US12378472

申请日：2009-02-12

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： B01J19/00

CPC分类号： A61M5/145 ,  A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36

摘要： Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, an acoustic control signal may be used.

公开(公告)号：US20100076414A1

公开(公告)日：2010-03-25

申请号：US12589847

申请日：2009-10-28

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M31/00 ,  G05D11/00 ,  G05D7/06 ,  G06F21/20

CPC分类号： A61K9/0009 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/172 ,  A61M5/1723 ,  A61M31/002 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36

摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

公开(公告)号：US20120289943A1

公开(公告)日：2012-11-15

申请号：US13554547

申请日：2012-07-20

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M37/00

CPC分类号： A61K9/0004 ,  A61K9/0009 ,  A61K9/0024 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36 ,  A61N1/08

摘要： Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

摘要翻译： 描述了包括远程控制的渗透泵装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，将渗透泵装置放置在环境中以便将材料泵送到渗透泵装置内的环境或另外的流体处理结构中。 示例性环境包括生物体，水体或封闭体积的流体。 在所选择的实施例中，可以使用磁场，电场或电磁控制信号。

公开(公告)号：US20100076415A1

公开(公告)日：2010-03-25

申请号：US12589881

申请日：2009-10-28

申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M31/00 ,  G05D11/00 ,  G05D7/06

CPC分类号： A61K9/0009 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/172 ,  A61M5/1723 ,  A61M31/002 ,  A61M2005/14513 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/36

摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

摘要翻译： 描述了包括远程控制物质输送装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，输送装置或相关装置可以放置在环境中，以便将材料泵入环境或装置内的附加流体处理结构。 示例性环境包括生物体，水体或封闭体积的流体。 被输送流体中物质的浓度可以通过遥控信号来改变。 在所选择的实施例中，可以使用磁场，电场或电磁控制信号。