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公开(公告)号：US07889341B2
公开(公告)日：2011-02-15
申请号：US12148671
申请日：2008-04-21
申请人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
发明人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
IPC分类号： G01N21/25
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0064 , G02B21/008
摘要： A multiphoton-excitation laser scanning microscope capable of efficiently collecting fluorescence emitted from a specimen to acquire a brighter multiphoton-excitation fluorescence image is provided. This multiphoton-excitation laser scanning microscope includes a multiphoton-excitation laser light source for emitting ultrashort pulsed laser light, a light-scanning unit configured to scan a specimen with the ultrashort pulsed laser light emitted from the multiphoton-excitation laser light source in two dimensions, an objective lens configured to focus the ultrashort pulsed laser light scanned by the light-scanning unit on the specimen, a collector lens disposed opposite the objective lens, with the light-scanning unit disposed therebetween, to collect fluorescence emitted from the specimen, and a light detector configured to detect the fluorescence collected by the collector lens. The collector lens has a higher numerical aperture and a larger field number than the objective lens.
摘要翻译： 提供能够有效地收集从样本发出的荧光以获得更明亮的多光子激发荧光图像的多光子激发激光扫描显微镜。 该多光子激发激光扫描显微镜包括用于发射超短脉冲激光的多光子激发激光光源，被配置为使用从多光子激发激光光源发射的超短脉冲激光二维扫描样本的光扫描单元 配置为将由所述光扫描单元扫描的超短脉冲激光对准在所述检体上的物镜，与所述物镜相对设置的集光透镜，其间设置有所述光扫描单元，以收集从所述检体发出的荧光，以及 光检测器，被配置为检测由所述收集透镜收集的荧光。 收集透镜具有比物镜更高的数值孔径和更大的场数。
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公开(公告)号：US20080266551A1
公开(公告)日：2008-10-30
申请号：US12148671
申请日：2008-04-21
申请人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
发明人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0064 , G02B21/008
摘要： A multiphoton-excitation laser scanning microscope capable of efficiently collecting fluorescence emitted from a specimen to acquire a brighter multiphoton-excitation fluorescence image is provided. This multiphoton-excitation laser scanning microscope includes a multiphoton-excitation laser light source for emitting ultrashort pulsed laser light, a light-scanning unit configured to scan a specimen with the ultrashort pulsed laser light emitted from the multiphoton-excitation laser light source in two dimensions, an objective lens configured to focus the ultrashort pulsed laser light scanned by the light-scanning unit on the specimen, a collector lens disposed opposite the objective lens, with the light-scanning unit disposed therebetween, to collect fluorescence emitted from the specimen, and a light detector configured to detect the fluorescence collected by the collector lens. The collector lens has a higher numerical aperture and a larger field number than the objective lens.
摘要翻译： 提供能够有效地收集从样本发出的荧光以获得更明亮的多光子激发荧光图像的多光子激发激光扫描显微镜。 该多光子激发激光扫描显微镜包括用于发射超短脉冲激光的多光子激发激光光源，被配置为使用从多光子激发激光光源发射的超短脉冲激光二维扫描样本的光扫描单元 配置为将由所述光扫描单元扫描的超短脉冲激光对准在所述检体上的物镜，与所述物镜相对设置的集光透镜，其间设置有所述光扫描单元，以收集从所述检体发出的荧光，以及 光检测器，被配置为检测由所述收集透镜收集的荧光。 收集透镜具有比物镜更高的数值孔径和更大的场数。
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公开(公告)号：US20070109634A1
公开(公告)日：2007-05-17
申请号：US11593842
申请日：2006-11-07
申请人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
发明人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G01N21/6458 , G01N2021/6439 , G02B21/0044 , G02B21/0076 , G02B21/0084 , G02B21/16 , G02B21/32
摘要： A microscope apparatus that can observe into the interior of a specimen and that can apply an optical stimulus over a wide area within a short period of time is provided. The microscope apparatus comprises at least one observation scanning optical system including a laser light source for emitting observation laser light, an objective lens, and a scanning optical system for two-dimensionally scanning the observation laser light in a predetermined examination plane of the specimen via the objective lens; and at least one stimulus optical system which includes a lamp light source for emitting light having a wavelength used for optical stimulation and which irradiates the specimen with the light emitted from the lamp light source.
摘要翻译： 提供了可以观察到样本内部并且可以在短时间内在广泛区域上施加光学刺激的显微镜装置。 显微镜装置包括至少一个观察扫描光学系统，其包括用于发射观察激光的激光光源，物镜和用于在样本的预定检查平面中二维扫描观察激光的扫描光学系统 物镜; 以及至少一个刺激光学系统，其包括用于发射具有用于光学刺激的波长的光的灯光源，并且从灯光源发射的光照射样本。
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公开(公告)号：US08154796B2
公开(公告)日：2012-04-10
申请号：US11593842
申请日：2006-11-07
申请人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
发明人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G01N21/6458 , G01N2021/6439 , G02B21/0044 , G02B21/0076 , G02B21/0084 , G02B21/16 , G02B21/32
摘要： A microscope apparatus that can observe into the interior of a specimen and that can apply an optical stimulus over a wide area within a short period of time is provided. The microscope apparatus comprises at least one observation scanning optical system including a laser light source for emitting observation laser light, an objective lens, and a scanning optical system for two-dimensionally scanning the observation laser light in a predetermined examination plane of the specimen via the objective lens; and at least one stimulus optical system which includes a lamp light source for emitting light having a wavelength used for optical stimulation and which irradiates the specimen with the light emitted from the lamp light source.
摘要翻译： 提供了可以观察到样本内部并且可以在短时间内在广泛区域上施加光学刺激的显微镜装置。 显微镜装置包括至少一个观察扫描光学系统，其包括用于发射观察激光的激光光源，物镜和用于在样本的预定检查平面中二维扫描观察激光的扫描光学系统 物镜; 以及至少一个刺激光学系统，其包括用于发射具有用于光学刺激的波长的光的灯光源，并且从灯光源发射的光照射样本。
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公开(公告)号：US07268344B2
公开(公告)日：2007-09-11
申请号：US11447761
申请日：2006-06-06
IPC分类号： G01J1/32
CPC分类号： G02B21/008 , G01N21/6458
摘要： A scanning laser microscope that can quantitatively display a laser irradiation power on a display unit and that can suppress fluctuations in the laser irradiation power is provided. The scanning laser microscope includes a light source configured to emit laser light, a scanning unit configured to scan the laser light emitted from the light source on a sample, a photodetector configured to detect light from the sample, a processing unit configured to convert a signal from the photodetector into an image signal of the sample and to output the image signal, a reference light detector configured to detect part of the laser light emitted from the light source as a reference light signal, a laser light control unit configured to control the power of the laser light emitted from the light source, an irradiation-power calculation unit configured to calculate an irradiation power value at the sample on the basis of the reference light signal detected by the reference light detector, and a display unit configured to display the calculated irradiation power value at the sample.
摘要翻译： 提供了一种可以在显示单元上定量显示激光照射功率并且可以抑制激光照射功率的波动的扫描激光显微镜。 该扫描激光显微镜包括配置为发射激光的光源，被配置为扫描从样品上的光源发射的激光的扫描单元，被配置为检测来自样品的光的光电检测器，被配置为将信号 从光电检测器到样品的图像信号并输出图像信号;参考光检测器，被配置为检测从光源发射的激光的一部分作为参考光信号;激光控制单元，被配置为控制功率 照射功率计算单元，被配置为基于由参考光检测器检测的参考光信号计算样本处的照射功率值;以及显示单元，被配置为显示所计算的 样品照射功率值。
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公开(公告)号：US08054542B2
公开(公告)日：2011-11-08
申请号：US12251602
申请日：2008-10-15
申请人： Hiroshi Sasaki , Yasunari Matsukawa
发明人： Hiroshi Sasaki , Yasunari Matsukawa
IPC分类号： G02B21/00
CPC分类号： G02B21/0032 , G02B21/0064 , G02B21/0076 , G02B21/008
摘要： A scanning laser microscope includes a laser light source; an acousto-optic deflector having a crystal, being arranged in an optical path of a laser beam emitted from the laser light source and capable of changing a traveling direction of the laser beam when frequencies of acoustic waves applied to the crystal are changed; a frequency control unit configured to simultaneously apply acoustic waves having a plurality of frequencies to the crystal of the acousto-optic deflector; an objective lens configured to converge the laser beam emitted from the laser light source to form a beam spot on a specimen; and an optical scanning device configured to two-dimensionally scan the scanning spot by deflecting the laser beam in two directions perpendicular to each other. The acousto-optic deflector, the optical scanning device, and a pupil of the objective lens are arranged at positions optically conjugate with each other.
摘要翻译： 扫描激光显微镜包括激光光源; 具有晶体的声光偏转器布置在从激光光源发射的激光束的光路中，并且当施加到晶体的声波的频率改变时能够改变激光束的行进方向; 频率控制单元，被配置为向声光偏转器的晶体同时施加具有多个频率的声波; 物镜，其被配置为会聚从激光光源发射的激光束，以在样本上形成束斑; 以及光学扫描装置，被配置为通过使激光束在彼此垂直的两个方向上偏转来二维地扫描扫描光点。 声光偏转器，光学扫描装置和物镜的光瞳被布置在彼此光学共轭的位置。
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公开(公告)号：US20060278530A1
公开(公告)日：2006-12-14
申请号：US11447761
申请日：2006-06-06
CPC分类号： G02B21/008 , G01N21/6458
摘要： A scanning laser microscope that can quantitatively display a laser irradiation power on a display unit and that can suppress fluctuations in the laser irradiation power is provided. The scanning laser microscope includes a light source configured to emit laser light, a scanning unit configured to scan the laser light emitted from the light source on a sample, a photodetector configured to detect light from the sample, a processing unit configured to convert a signal from the photodetector into an image signal of the sample and to output the image signal, a reference light detector configured to detect part of the laser light emitted from the light source as a reference light signal, a laser light control unit configured to control the power of the laser light emitted from the light source, an irradiation-power calculation unit configured to calculate an irradiation power value at the sample on the basis of the reference light signal detected by the reference light detector, and a display unit configured to display the calculated irradiation power value at the sample.
摘要翻译： 提供了一种可以在显示单元上定量显示激光照射功率并且可以抑制激光照射功率的波动的扫描激光显微镜。 该扫描激光显微镜包括配置为发射激光的光源，被配置为扫描从样品上的光源发射的激光的扫描单元，被配置为检测来自样品的光的光电检测器，被配置为将信号 从光电检测器到样品的图像信号并输出图像信号;参考光检测器，被配置为检测从光源发射的激光的一部分作为参考光信号;激光控制单元，被配置为控制功率 照射功率计算单元，被配置为基于由参考光检测器检测的参考光信号计算样本处的照射功率值;以及显示单元，被配置为显示所计算的 样品照射功率值。
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公开(公告)号：US20220270062A1
公开(公告)日：2022-08-25
申请号：US17556021
申请日：2021-12-20
申请人： Hiroshi Sasaki
发明人： Hiroshi Sasaki
摘要： Methods and systems with “selective-information-revealing” features are described. The features enable a user of an online platform such as an online forum or online publishing platform to post content with one or more elements masked. With the features, an automatically generated suggestion of one or more elements of the content to mask is presented with the suggested elements visually differentiated from the other elements of the content. User interface elements are also provided enabling the user to modify the set of elements to be masked. Further described are additional earn-from-content features enabling a user to be rewarded by disclosing his masked content or selling the privilege of exclusive capabilities regarding his content to another user, and “share-revenue” features enabling revenue earned via earn-from-content features to be shared among a plurality of users.
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公开(公告)号：US08742430B2
公开(公告)日：2014-06-03
申请号：US12542085
申请日：2009-08-17
申请人： Masao Shimizu , Shingo Ishihara , Hiroshi Sasaki , Tatsuya Sugita
发明人： Masao Shimizu , Shingo Ishihara , Hiroshi Sasaki , Tatsuya Sugita
IPC分类号： H01L27/15
CPC分类号： H01L51/5268 , B82Y20/00 , B82Y30/00 , H01L2251/5369
摘要： An object of the present invention is to provide an organic light emitting element where light emitted from the light emitting layer is efficiently emitted to the outside, and thus, the efficiency of light emission is higher. The present invention provides an organic light emitting element where a first reflective electrode 22, an electron transport layer 23, a light emitting layer 24, a hole transport layer 25, a hole injection layer 26 and a second transparent electrode 27 are formed on a glass substrate 21, and a light extraction layer 28 having an average index of refraction of 1.4 made of titanium particles having an index of refraction of 2.6 and an average particle diameter of 150 nm and silica sol.
摘要翻译： 本发明的目的是提供一种有机发光元件，其中从发光层发射的光被有效地发射到外部，因此发光效率更高。 本发明提供一种有机发光元件，其中在玻璃上形成第一反射电极22，电子传输层23，发光层24，空穴传输层25，空穴注入层26和第二透明电极27 基板21和折射率为2.6，平均粒径为150nm的钛颗粒的平均折射率为1.4的光提取层28和二氧化硅溶胶。
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公开(公告)号：US08723937B2
公开(公告)日：2014-05-13
申请号：US13049055
申请日：2011-03-16
申请人： Hiroshi Sasaki
发明人： Hiroshi Sasaki
CPC分类号： A61B1/00096 , A61B1/00009 , A61B1/00188 , A61B1/05 , G02B23/2407
摘要： An endoscope system includes an imaging section that includes an optical system and an imaging element, an observation mode setting section that sets an object observation mode, a diaphragm control section that selects a diaphragm state based on the observation mode, and an image processing section that processes an image acquired by the imaging section. The diaphragm control section selecting a first diaphragm state when the observation mode is a first observation mode. The first diaphragm state being a state in which a resolution determined by a diffraction limit based on a diaphragm of the optical system is lower than a resolution determined by the imaging element. The diaphragm control section selecting a second diaphragm state when the observation mode is a second observation mode. The second diaphragm state being a state in which the resolution determined by the diffraction limit based on the diaphragm of the optical system is equal to or higher than the resolution determined by the imaging element.
摘要翻译： 一种内窥镜系统，包括：摄像部，其具备光学系统和摄像元件，设定被摄体观察模式的观察模式设定部，基于观察模式选择光阑状态的光圈控制部;以及图像处理部， 处理由成像部获取的图像。 当观察模式是第一观察模式时，光圈控制部分选择第一光阑状态。 第一光阑状态是其中由基于光学系统的光阑的衍射极限决定的分辨率低于由成像元件确定的分辨率的状态。 当观察模式是第二观察模式时，光圈控制部分选择第二光阑状态。 第二光阑状态是基于光学系统的光阑的由衍射极限决定的分辨率等于或高于由成像元件确定的分辨率的状态。
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