公开(公告)号：US09238634B2

公开(公告)日：2016-01-19

申请号：US13817079

申请日：2011-08-04

申请人： Makoto Arita ,  Hiroyuki Arai ,  Yosuke Isobe ,  Tadafumi Kubota

发明人： Makoto Arita ,  Hiroyuki Arai ,  Yosuke Isobe ,  Tadafumi Kubota

IPC分类号： A01N43/20 ,  A01N43/24 ,  A61K31/335 ,  C07D303/14 ,  C07D303/38 ,  C12P7/64 ,  C12P17/02 ,  G01N30/34 ,  G01N30/72 ,  G01N30/88

CPC分类号： C07D303/14 ,  C07D303/38 ,  C12P7/6427 ,  C12P17/02 ,  C12Y113/11 ,  G01N30/34 ,  G01N30/7233 ,  G01N2030/884

摘要： The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.

摘要翻译： 目的是提供一种可以克服常规类固醇药物和NSAID的缺点的化合物。 发现由式[化学式1]，[化学式5]等独立地表示的二十碳五烯酸，二十二碳六烯酸和二十二碳五烯酸的特定环氧单羟基形式对中性粒细胞具有抑制活性。 这种化合物可以抑制嗜中性粒细胞侵袭到组织中，并且可以在急性炎症中观察到嗜中性粒细胞的活化。

公开(公告)号：US20130274327A1

公开(公告)日：2013-10-17

申请号：US13817079

申请日：2011-08-04

申请人： Makoto Arita ,  Hiroyuki Arai ,  Yosuke Isobe ,  Tadafumi Kubota

发明人： Makoto Arita ,  Hiroyuki Arai ,  Yosuke Isobe ,  Tadafumi Kubota

IPC分类号： C07D303/14

CPC分类号： C07D303/14 ,  C07D303/38 ,  C12P7/6427 ,  C12P17/02 ,  C12Y113/11 ,  G01N30/34 ,  G01N30/7233 ,  G01N2030/884

摘要： The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.

摘要翻译： 目的是提供一种可以克服常规类固醇药物和NSAID的缺点的化合物。 发现由式[化学式1]，[化学式5]等独立地表示的二十碳五烯酸，二十二碳六烯酸和二十二碳五烯酸的特定环氧单羟基形式对中性粒细胞具有抑制活性。 这种化合物可以抑制嗜中性粒细胞侵袭到组织中，并且可以在急性炎症中观察到嗜中性粒细胞的活化。

公开(公告)号：US20100191003A1

公开(公告)日：2010-07-29

申请号：US12665712

申请日：2008-06-13

申请人： Yosuke Isobe ,  Shuichi Kamo ,  Toshiro Sato ,  Horoyuki Yoshida

发明人： Yosuke Isobe ,  Shuichi Kamo ,  Toshiro Sato ,  Horoyuki Yoshida

IPC分类号： C07D311/36 ,  C07D309/32

CPC分类号： C07J63/00 ,  C07D309/32 ,  C07D311/36 ,  C07D311/40

摘要： It is intended to provide a method for producing aglycone from a glycoside efficiently at low cost without using an acid catalyst or an organic solvent. The method for producing aglycone, characterized by bringing a glycoside into contact with high temperature high pressure water. The temperature of the high temperature high pressure water is generally from 100 to 374° C., preferably from 140 to 320° C., more preferably from 200 to 300° C. The pressure of the high temperature high pressure water may be not lower than the saturated water vapor pressure at the temperature, i.e., a pressure at which the liquid state is maintained.

摘要翻译： 旨在提供一种以低成本有效地从糖苷生产糖苷配基的方法，而不使用酸催化剂或有机溶剂。 制备糖苷配基的方法，其特征在于使糖苷与高温高压水接触。 高温高压水的温度通常为100〜374℃，优选为140〜320℃，更优选为200〜300℃。高温高压水的压力可能不低 比在该温度下的饱和水蒸汽压力，即保持液体状态的压力。

公开(公告)号：US08273906B2

公开(公告)日：2012-09-25

申请号：US12665712

申请日：2008-06-13

申请人： Yosuke Isobe ,  Shuichi Kamo ,  Toshiro Sato ,  Hiroyuki Yoshida

发明人： Yosuke Isobe ,  Shuichi Kamo ,  Toshiro Sato ,  Hiroyuki Yoshida

IPC分类号： C07D309/32 ,  C07D311/30 ,  C07C35/34 ,  C07C49/377

CPC分类号： C07J63/00 ,  C07D309/32 ,  C07D311/36 ,  C07D311/40

摘要： It is intended to provide a method for producing aglycone from a glycoside efficiently at low cost without using an acid catalyst or an organic solvent. The method for producing aglycone, characterized by bringing a glycoside into contact with high temperature high pressure water. The temperature of the high temperature high pressure water is generally from 100 to 374° C., preferably from 140 to 320° C., more preferably from 200 to 300° C. The pressure of the high temperature high pressure water may be not lower than the saturated water vapor pressure at the temperature, i.e., a pressure at which the liquid state is maintained.

摘要翻译： 旨在提供一种以低成本有效地从糖苷生产糖苷配基的方法，而不使用酸催化剂或有机溶剂。 制备糖苷配基的方法，其特征在于使糖苷与高温高压水接触。 高温高压水的温度通常为100〜374℃，优选为140〜320℃，更优选为200〜300℃。高温高压水的压力可能不低 比在该温度下的饱和水蒸汽压力，即保持液体状态的压力。

公开(公告)号：US20100183797A1

公开(公告)日：2010-07-22

申请号：US12664675

申请日：2008-06-13

申请人： Keiko Yamaku ,  Masaru Goto ,  Yosuke Isobe ,  Hiroyuki Yoshida

发明人： Keiko Yamaku ,  Masaru Goto ,  Yosuke Isobe ,  Hiroyuki Yoshida

IPC分类号： C08B30/00 ,  A23L1/05

CPC分类号： C08B30/12 ,  A23L29/219

摘要： It is intended to provide a method of easily and economically producing starch which has an increased content of less digestible starch. The method of producing starch having a high content of less digestible starch is characterized by comprising contacting starch with hot water at a temperature of 160 to 260° C. which has a pressure corresponding to the saturated vapor pressure at that temperature or more.

摘要翻译： 旨在提供一种容易且经济地生产淀粉含量较低的消化淀粉的方法。 具有高消化率淀粉含量的淀粉的制造方法的特征在于包括使淀粉与温度为160〜260℃的热水接触，该压力对应于该温度以上的饱和蒸气压。

公开(公告)号：US20090118226A1

公开(公告)日：2009-05-07

申请号：US12302823

申请日：2007-05-21

申请人： Kazunari Ushida ,  Sanshiro Saito ,  Toshiro Sato ,  Yosuke Isobe ,  Koki Fujita ,  Tetsuya Ito

发明人： Kazunari Ushida ,  Sanshiro Saito ,  Toshiro Sato ,  Yosuke Isobe ,  Koki Fujita ,  Tetsuya Ito

IPC分类号： A61K31/7004 ,  A61K31/702 ,  A61K31/715

CPC分类号： A23K20/163 ,  A23L33/21 ,  A61K31/7016 ,  A61K31/702

摘要： To promote the growth of human beings or animals, prevent the onset of diarrhea and prevent or ameliorate various diseases, it is intended to provide a substance which has an effect of decreasing eosinophils in the intestinal tract and a feed comprising the same as a feed additive. Namely, an intestinal eosinophil-suppressing composition which contains an ▪-linked galactooligosaccharide as the active ingredient. When added in an amount of from 0.01 to 10% by weight, in terms of the saccharide, to an animal feed, this composition is useful in providing an intestinal eosinophil-suppressing feed.

摘要翻译： 为了促进人类或动物的生长，预防腹泻的发生并预防或改善各种疾病，旨在提供一种具有减少肠道嗜酸性粒细胞的作用的物质和包含与饲料添加剂相同的饲料 。 即，含有β-连接的低聚半乳糖作为活性成分的肠嗜酸性粒细胞抑制组合物。 当添加量为0.01〜10重量％，就糖而言，与动物饲料相比，该组合物可用于提供肠嗜酸性粒细胞抑制饲料。