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    2-naphthamide derivatives
    1.
    发明申请
    2-naphthamide derivatives 审中-公开
    2-萘甲酰胺衍生物

    公开(公告)号：US20060166989A1

    公开(公告)日：2006-07-27

    申请号：US10517677

    申请日：2003-05-30

    申请人： Makoto Shimazaki ,  Osamu Sakurai ,  Toshiki Murata ,  Klaus Urbahns ,  Noriyuki Yamamoto ,  Satoru Yoshikawa ,  Masaomi Umeda ,  Masaomi Tajimi ,  Tsutomu Masuda ,  Takuya Shintani ,  Haruka Shimizu

    发明人： Makoto Shimazaki ,  Osamu Sakurai ,  Toshiki Murata ,  Klaus Urbahns ,  Noriyuki Yamamoto ,  Satoru Yoshikawa ,  Masaomi Umeda ,  Masaomi Tajimi ,  Tsutomu Masuda ,  Takuya Shintani ,  Haruka Shimizu

    IPC分类号： A61K31/537 ,  A61K31/44 ,  A61K31/195 ,  C07D213/55 ,  C07D265/30 ,  C07C237/40

    CPC分类号： C07C235/66

    摘要： The present invention relates to 2-naphthamides, which are useful as an active ingredient of pharmaceutical preparations. The 2-naphthamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benign prostatic hypertrophy (BPH), pro-statitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the disease is also alleviated by treatment with an IP receptor antagonist.

    摘要翻译： 本发明涉及可用作药物制剂活性成分的2-萘甲酰胺。 本发明的2-萘甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体活性相关的疾病。 这些疾病包括尿路疾病或病症如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大 ），pro-statitis，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺增生症，膀胱炎或自发性膀胱过敏反应。 本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压 血友病和出血; 和炎症，因为该疾病也通过用IP受体拮抗剂治疗而缓解。

    Carboxamides derivatives
    2.
    发明申请
    Carboxamides derivatives 审中-公开
    甲酰胺衍生物

    公开(公告)号：US20060135613A1

    公开(公告)日：2006-06-22

    申请号：US10517646

    申请日：2003-06-12

    申请人： Makoto Shimazaki ,  Osamu Sakurai ,  Kanako Hirai ,  Klaus Urbahns ,  Noriyuki Yamamoto ,  Satoru Yoshikawa ,  Masaomi Umeda ,  Masaomi Tajimi

    发明人： Makoto Shimazaki ,  Osamu Sakurai ,  Kanako Hirai ,  Klaus Urbahns ,  Noriyuki Yamamoto ,  Satoru Yoshikawa ,  Masaomi Umeda ,  Masaomi Tajimi

    IPC分类号： A61K31/198 ,  A61K31/195 ,  C07C237/38

    CPC分类号： C07C235/34

    摘要： The present invention relates to carboxamides which are useful as an active ingredient of pharmaceutical preparations. The carboxamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the diseases are alleviated by treatment with an IP receptor antagonist.

    摘要翻译： 本发明涉及可用作药物制剂活性成分的羧酰胺。 本发明的甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体拮抗活性相关的疾病。 这些疾病包括泌尿系统疾病或紊乱，如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱反应过度，前列腺肥大 ），前列腺炎，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺痛，膀胱炎或自发性膀胱过敏。 本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压 血友病和出血; 和炎症，因为通过用IP受体拮抗剂治疗来减轻疾病。