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公开(公告)号：US09593108B2
公开(公告)日：2017-03-14
申请号：US13259283
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/506 , A61P31/14 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US20120135999A1
公开(公告)日：2012-05-31
申请号：US13259283
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： A61K31/501 , C07D487/04 , C12N7/06 , A61K31/437 , A61P31/14 , A61K31/519 , A61K31/497 , A61P31/12 , A61P31/18 , A61P31/22 , C07D471/04 , A61K31/506
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US20120184574A1
公开(公告)日：2012-07-19
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , A61P31/20 , A61P31/12 , A61P31/22 , A61P31/18 , A61P31/14 , C07D401/04 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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4.发明授权Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权β-氨基杂环二肽基肽酶抑制剂，用于治疗或预防糖尿病公开(公告)号：US06699871B2
公开(公告)日：2004-03-02
申请号：US10189603
申请日：2002-07-05
申请人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： C07D48704
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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公开(公告)号：US06500844B1
公开(公告)日：2002-12-31
申请号：US09590487
申请日：2000-06-08
IPC分类号： A61K31445
CPC分类号： C07D401/08 , C07D211/58 , C07D413/08
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R7, R8, X, Y, Z, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I化合物（其中R1，R2，R3，R7，R8，X，Y，Z，x和y如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。
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6.发明授权
公开(公告)号：US5908842A
公开(公告)日：1999-06-01
申请号：US836863
申请日：1997-05-20
IPC分类号： C07D213/75 , A61K31/34 , A61K31/44 , C07D215/38
CPC分类号： C07D213/75
摘要： Substituted 2-acylaminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.
摘要翻译： PCT No.PCT / US95 / 16158 Sec。 371日期：1997年5月22日 102（e）日期1997年5月22日PCT提交1995年12月8日PCT公布。 公开号WO96 / 18617 日期1996年6月20日已经发现可用于治疗一氧化氮合酶介导的疾病和病症的取代的2-酰基氨基吡啶化合物和药学上可接受的盐。
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7.发明授权
公开(公告)号：US5691336A
公开(公告)日：1997-11-25
申请号：US525870
申请日：1995-09-08
IPC分类号： A61K31/535 , A61K31/5355 , A61K31/5375 , A61P1/00 , A61P1/08 , A61P3/00 , A61P11/00 , A61P11/08 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P29/00 , C07D265/30 , C07D265/32 , C07D265/34 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07F9/6558 , C07D279/12
CPC分类号： C07D265/30 , C07D265/32 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07F9/65583
摘要： Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma, and emesis.
摘要翻译： 取代的通式结构式的杂环：
是可用于治疗炎性疾病，疼痛或偏头痛，哮喘和呕吐的速激肽受体拮抗剂。 -
8.发明授权Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone 失效含有2-氮杂环丁酮4-位的亚磷酸衍生物的新型β-内酰胺弹性蛋白酶抑制剂
公开(公告)号：US5100880A
公开(公告)日：1992-03-31
申请号：US672222
申请日：1991-03-20
IPC分类号： A61K31/675 , A61P29/00 , C07D205/08 , C07F9/568
CPC分类号： C07F9/568 , Y10S514/851
摘要： New substituted azetidinones of the general formula (A), which have been found to be potent elastase inhibitors and thereby useful as anti-inflammatory and antidegenerative agents, are described. ##STR1##
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公开(公告)号：US06506777B1
公开(公告)日：2003-01-14
申请号：US09589972
申请日：2000-06-08
IPC分类号： A61K31445
CPC分类号： C07D409/12 , C07D211/58
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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公开(公告)号：US06235735B1
公开(公告)日：2001-05-22
申请号：US09526843
申请日：2000-03-16
申请人： Conrad P. Dorn , Jeffrey J Hale , Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Tamara Ladduwahetty , Timothy Harrison , Brian John Williams
发明人： Conrad P. Dorn , Jeffrey J Hale , Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Tamara Ladduwahetty , Timothy Harrison , Brian John Williams
IPC分类号： A61K315355
CPC分类号： A61K31/41 , A61K31/50 , A61K31/53 , A61K31/535 , A61K31/54 , C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , Y10S514/872
摘要： Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译： 取代的通式结构式的杂环是用于治疗炎性疾病，疼痛或偏头痛，哮喘和呕吐的速激肽受体拮抗剂，以及可用于治疗心血管疾病如心绞痛，高血压或缺血的钙通道阻滞剂。
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