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1.发明授权Methods of treatment of autoimmune diseases using humanized immunoglobulin reactive with B7-2 失效使用与B7-2反应的人源化免疫球蛋白治疗自身免疫性疾病的方法公开(公告)号：US07666421B2
公开(公告)日：2010-02-23
申请号：US11294680
申请日：2005-12-05
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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2.发明授权Methods for modulation of immune responses using humanized immunoglobulins reactive with B7-1 molecules 失效使用与B7-1分子反应的人源化免疫球蛋白调节免疫应答的方法公开(公告)号：US07531175B2
公开(公告)日：2009-05-12
申请号：US10986089
申请日：2004-11-12
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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3.发明授权Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins 失效通过使供体细胞与B7-1和B7-2特异性免疫球蛋白接触来移植细胞的方法公开(公告)号：US06984383B1
公开(公告)日：2006-01-10
申请号：US09626731
申请日：2000-07-27
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , A61K35/26 , A61K35/28 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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公开(公告)号：US06913747B1
公开(公告)日：2005-07-05
申请号：US09339596
申请日：1999-06-24
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13 , C12N15/63
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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5.发明授权Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith 失效与B7-2反应的人源化免疫球蛋白及其治疗方法公开(公告)号：US06972125B2
公开(公告)日：2005-12-06
申请号：US09249011
申请日：1999-02-12
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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6.发明授权Humanized immunoglobulin reactive with b7-2 and methods of treatment therewith 失效与b7-2反应的人源化免疫球蛋白及其治疗方法公开(公告)号：US06827934B1
公开(公告)日：2004-12-07
申请号：US09627896
申请日：2000-07-27
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman , Gary S. Gray
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman , Gary S. Gray
IPC分类号： A61K39395
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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7.发明授权Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity 有权编码降低GDF-8活性的抗体的分离的核酸分子公开(公告)号：US08710202B2
公开(公告)日：2014-04-29
申请号：US13346042
申请日：2012-01-09
申请人： Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , A61K39/395
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20120107928A1
公开(公告)日：2012-05-03
申请号：US13346042
申请日：2012-01-09
申请人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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9.发明授权Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8 有权通过针对GDF-8的抗体在有需要的患者中增加小梁骨密度的方法公开(公告)号：US08092798B2
公开(公告)日：2012-01-10
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20110020330A1
公开(公告)日：2011-01-27
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
IPC分类号： A61K39/395 , C07H21/04 , A61P19/08 , C12N5/07
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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