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1.发明授权Methods of treatment of autoimmune diseases using humanized immunoglobulin reactive with B7-2 失效使用与B7-2反应的人源化免疫球蛋白治疗自身免疫性疾病的方法公开(公告)号：US07666421B2
公开(公告)日：2010-02-23
申请号：US11294680
申请日：2005-12-05
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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2.发明授权Methods for modulation of immune responses using humanized immunoglobulins reactive with B7-1 molecules 失效使用与B7-1分子反应的人源化免疫球蛋白调节免疫应答的方法公开(公告)号：US07531175B2
公开(公告)日：2009-05-12
申请号：US10986089
申请日：2004-11-12
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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3.发明授权Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins 失效通过使供体细胞与B7-1和B7-2特异性免疫球蛋白接触来移植细胞的方法公开(公告)号：US06984383B1
公开(公告)日：2006-01-10
申请号：US09626731
申请日：2000-07-27
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , A61K35/26 , A61K35/28 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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公开(公告)号：US06913747B1
公开(公告)日：2005-07-05
申请号：US09339596
申请日：1999-06-24
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13 , C12N15/63
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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5.发明授权Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith 失效与B7-2反应的人源化免疫球蛋白及其治疗方法公开(公告)号：US06972125B2
公开(公告)日：2005-12-06
申请号：US09249011
申请日：1999-02-12
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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6.发明授权Humanized immunoglobulin reactive with b7-2 and methods of treatment therewith 失效与b7-2反应的人源化免疫球蛋白及其治疗方法公开(公告)号：US06827934B1
公开(公告)日：2004-12-07
申请号：US09627896
申请日：2000-07-27
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman , Gary S. Gray
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman , Gary S. Gray
IPC分类号： A61K39395
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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7.发明申请Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith 失效与B7-2反应的人源化免疫球蛋白及其治疗方法公开(公告)号：US20060251645A1
公开(公告)日：2006-11-09
申请号：US11294680
申请日：2005-12-05
申请人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
发明人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/44 , C12N5/06
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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8.发明申请Humanized immunoglobulin reactive with B7 molecules and methods of treatment therewith 失效与B7分子反应的人源化免疫球蛋白及其治疗方法公开(公告)号：US20050208042A1
公开(公告)日：2005-09-22
申请号：US10986089
申请日：2004-11-12
申请人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
发明人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
IPC分类号： G01N33/53 , A61K31/436 , A61K31/519 , A61K31/573 , A61K35/14 , A61K35/28 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/00 , A61P3/10 , A61P7/00 , A61P7/06 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , C07K16/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , G01N33/533 , G01N33/534 , G01N33/535 , C07K16/44
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译： 本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。 本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。
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9.发明授权Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody 失效抗Fas配体抗体和使用抗Fas配体抗体的测定方法
公开(公告)号：US6114507A
公开(公告)日：2000-09-05
申请号：US649100
申请日：1996-05-17
CPC分类号： C07K16/2875 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2319/00
摘要： An anti-Fas ligand antibody capable of suppressing Fas ligand-induced apoptosis to a high degree, especially humanized antibodies having less antigenecity to human, and a method for assaying the Fas ligand in human body fluid utilizing such an antibody.Measurement of the Fas ligand in human body fluid would be useful for elucidation of hepatitis B, hepatitis C, HIV infections and the like, and for prediction and diagnosis of pathological conditions associated with such diseases.
摘要翻译： 能够高度抑制Fas配体诱导的凋亡的抗Fas配体抗体，特别是对人具有较小抗原性的人源化抗体，以及利用这种抗体测定人体液体中的Fas配体的方法。 人体液体中Fas配体的测定可用于阐明乙型肝炎，丙型肝炎，艾滋病毒感染等，以及与这些疾病相关的病理状况的预测和诊断。
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10.发明授权Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody 有权抗血栓形成剂和人源化抗血小板血友病因子单克隆抗体公开(公告)号：US07138116B2
公开(公告)日：2006-11-21
申请号：US10289181
申请日：2002-11-07
申请人： Man Sung Co , Maximiliano Vasquez
发明人： Man Sung Co , Maximiliano Vasquez
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor.
摘要翻译： 含有结合von Willebrand因子的人源化抗体的抗血栓形成剂。
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