公开(公告)号：US20130035250A1

公开(公告)日：2013-02-07

申请号：US13516070

申请日：2010-12-15

申请人： Manfred Wirth ,  Susanne Fuessel ,  Rainer Koch

发明人： Manfred Wirth ,  Susanne Fuessel ,  Rainer Koch

IPC分类号： C12Q1/68 ,  C40B30/04

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer comprising the analysis of the expression of the marker gene hepsin in an urine sample. It further relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer by determining the expression levels of the marker genes hepsin, EZH2, prostein and PCA3.

摘要翻译： 本发明涉及用于诊断前列腺癌的非侵入性方法和/或评估获得前列腺癌的受试者的风险，其包括对尿样中标记基因hepsin的表达的分析。 它还涉及用于诊断前列腺癌的非侵入性方法和/或通过确定标记基因hepsin，EZH2，prostein和PCA3的表达水平来评估获得前列腺癌的受试者的风险。

公开(公告)号：US08697358B2

公开(公告)日：2014-04-15

申请号：US13516070

申请日：2010-12-15

申请人： Manfred Wirth ,  Susanne Fuessel ,  Rainer Koch

发明人： Manfred Wirth ,  Susanne Fuessel ,  Rainer Koch

IPC分类号： C12Q1/68 ,  C40B30/04

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer comprising the analysis of the expression of the marker gene hepsin in an urine sample. It further relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer by determining the expression levels of the marker genes hepsin, EZH2, prostein and PCA3.

摘要翻译： 本发明涉及用于诊断前列腺癌的非侵入性方法和/或评估获得前列腺癌的受试者的风险，其包括对尿样中标记基因hepsin的表达的分析。 它还涉及用于诊断前列腺癌的非侵入性方法和/或通过确定标记基因hepsin，EZH2，prostein和PCA3的表达水平来评估获得前列腺癌的受试者的风险。

公开(公告)号：US20110081721A1

公开(公告)日：2011-04-07

申请号：US12941756

申请日：2010-11-08

申请人： Gouya Ram-Liebig ,  Ursula Ravens ,  Manfred Wirth

发明人： Gouya Ram-Liebig ,  Ursula Ravens ,  Manfred Wirth

IPC分类号： C12N5/071

CPC分类号： A61L27/3895 ,  A61L27/3826 ,  A61L27/3882 ,  A61L27/50 ,  A61L2430/22

摘要： A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught.

摘要翻译： 一种用于生产用于重建人或动物器官的组织移植构建体的方法。 该方法可以包括以下步骤：（a）器官特异性组织细胞的分离和二维培养; （b）将器官特异性组织细胞施用于生物相容的含胶原的膜; 和（c）用器官特异性组织细胞的生化和机械刺激培养膜上的器官特异性组织细胞。 还教导了组织移植结构和使用组织移植构建体的方法。

公开(公告)号：US20100184220A1

公开(公告)日：2010-07-22

申请号：US12280916

申请日：2007-02-28

申请人： Gouya Ram-Liebig ,  Manfred Wirth

发明人： Gouya Ram-Liebig ,  Manfred Wirth

IPC分类号： C12N5/071

CPC分类号： A61L27/3895 ,  A61L27/3808 ,  A61L27/3882 ,  A61L2430/22 ,  C12N5/069 ,  C12N5/0692 ,  C12N5/0697

摘要： The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ. Here said tissue transplant construct is intended to comprise(a) a biocompatible acellular membrane and (b) microvascular endothelial cells which penetrate the membrane, wherein microvascular structures of microvascular endothelial cells are formed within the membrane.

摘要翻译： 本发明涉及用于重建人或动物器官的组织移植构建体。 这里所述的组织移植构建物旨在包括（a）生物相容的无细胞膜和（b）穿透膜的微血管内皮细胞，其中在膜内形成微血管内皮细胞的微血管结构。

公开(公告)号：US06706524B2

公开(公告)日：2004-03-16

申请号：US09954243

申请日：2001-09-17

申请人： Roland Wagner ,  Noushin Irani ,  Manfred Wirth ,  Joop Van Der Heuvel

发明人： Roland Wagner ,  Noushin Irani ,  Manfred Wirth ,  Joop Van Der Heuvel

IPC分类号： C12N500

CPC分类号： C12N9/93

摘要： The invention relates to a method of improving the primary energy metabolism of mammalian cell lines, in which by means of genetic engineering a structural gene for a cytoplasmic yeast pyruvate carboxylase is inserted into the mammalian cells and expressed.

摘要翻译： 本发明涉及一种改善哺乳动物细胞系的一次能量代谢的方法，其中通过遗传工程将细胞质酵母丙酮酸羧化酶的结构基因插入到哺乳动物细胞中并进行表达。

公开(公告)号：US20070034454A1

公开(公告)日：2007-02-15

申请号：US11459162

申请日：2006-07-21

申请人： Florian Dold ,  Adolf Bissig ,  Manfred Wirth ,  Claudio De Angelis

发明人： Florian Dold ,  Adolf Bissig ,  Manfred Wirth ,  Claudio De Angelis

IPC分类号： B66B7/08

CPC分类号： B66B7/062 ,  Y10T24/3969

摘要： In an elevator installation, an apparatus and a method use a support end connection for fastening a support device to an elevator car, a counterweight and/or a building. The support device has at least one cable or cable strand enclosed by a cable casing and is held in a wedge pocket by a wedge. The cable casing is formed of thermoplastic material or an elastomer and the cable or the cable strand is glued to, fused together with or mechanically connected with the cable casing in the region of the support end connection. A friction force transmitted from the support end connection to the cable casing can then be directly passed on to the load-bearing core of the support device, to the cables or to the cable strands. The tolerable tension force in the support device is increased. The support device is preferably a multiple cable.

摘要翻译： 在电梯安装中，装置和方法使用支撑端连接来将支撑装置紧固到电梯轿厢，配重和/或建筑物。 支撑装置具有由电缆壳体包围的至少一个电缆或电缆线束，并通过楔块保持在楔形凹槽中。 电缆壳体由热塑性材料或弹性体形成，并且电缆或电缆股线在支撑端连接的区域中胶合并与电缆壳体熔合在一起或与电缆壳体机械连接。 然后可以将从支撑端连接传递到电缆壳体的摩擦力直接传递到支撑装置的承载芯，电缆或电缆股线上。 支撑装置中的容许张力增加。 支撑装置优选为多根电缆。

公开(公告)号：US20070032440A1

公开(公告)日：2007-02-08

申请号：US10545093

申请日：2004-02-09

申请人： Axel Meye ,  Susanne Fussel ,  Manfred Wirth ,  Uta Schmidt-Strassbuger ,  Bernd Kuppers ,  Helge Taubert ,  Matthias Kappler ,  Matthias Bache ,  Frank Bartel ,  Peter Wurl

发明人： Axel Meye ,  Susanne Fussel ,  Manfred Wirth ,  Uta Schmidt-Strassbuger ,  Bernd Kuppers ,  Helge Taubert ,  Matthias Kappler ,  Matthias Bache ,  Frank Bartel ,  Peter Wurl

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/14

摘要： The present invention relates to oligonucleotides directed against a survivin gene and variants thereof and to the use of said oligonucleotides in the diagnosis, prophylaxis, reduction and follow-up of diseases associated with cell growth, differentiation and/or division, such as tumor diseases.

摘要翻译： 本发明涉及针对存活蛋白基因及其变体的寡核苷酸以及所述寡核苷酸在与细胞生长，分化和/或分裂相关的疾病如肿瘤疾病的诊断，预防，减少和随访中的用途。

公开(公告)号：US20050034615A1

公开(公告)日：2005-02-17

申请号：US10473148

申请日：2002-04-06

申请人： Helmut Holm ,  Manfred Liebler ,  Manfred Wirth

发明人： Helmut Holm ,  Manfred Liebler ,  Manfred Wirth

IPC分类号： B41F13/24 ,  B41F7/02 ,  B41F7/04 ,  B41F7/12 ,  B41F13/00 ,  B41F13/004 ,  B41F13/008 ,  B41F13/08 ,  B41F13/10 ,  B41F13/28 ,  B41F13/30 ,  B41F13/32 ,  B41F13/36 ,  B41F13/40

CPC分类号： B41F13/10 ,  B41F7/12 ,  B41F13/0045 ,  B41F13/008 ,  B41F13/28 ,  B41F13/30 ,  B41F13/32 ,  B41F13/36 ,  B41F27/10 ,  B41F27/12 ,  B41P2213/20 ,  B41P2213/206 ,  B41P2213/734 ,  B41P2227/10 ,  B41P2227/11

摘要： A printing couple in a printing machine is comprised of at least three cylinders, a forme cylinder, a transfer cylinder and a counter-pressure cylinder. The counter-pressure cylinder forms a printing location or point in cooperation with the transfer cylinder. The transfer cylinder is mounted in at least one lever which can be pivoted about an eccentrically pivoting axis in relation to the rotational axis of the forme cylinder. When the three cylinders are in a print position, a connecting plane through the axis of rotation of the forme cylinder and the pivoting axis of the lever forms an angle of between 25° and 65° with a plane through the axis of rotation of the cylinder forming the printing point.

摘要翻译： 印刷机中的印刷对由至少三个圆柱体，成型滚筒，传送滚筒和反压筒组成。 反压缸与传送滚筒配合形成打印位置或点。 传送滚筒安装在至少一个杠杆中，该杠杆可相对于成型滚筒的旋转轴线绕偏心枢转的轴线枢转。 当三个气缸处于打印位置时，通过成型气缸的旋转轴线和杆的枢转轴线的连接平面与通过气缸的旋转轴线的平面形成在25°和65°之间的角度 形成印刷点。

公开(公告)号：US08632432B2

公开(公告)日：2014-01-21

申请号：US11863596

申请日：2007-09-28

申请人： Adolf Bissig ,  Alessandro D'Apice ,  Herbert Bachmann ,  Manfred Wirth ,  Roland Lorenz ,  Tobias Noseda ,  Florian Dold ,  Claudio De Angelis

发明人： Adolf Bissig ,  Alessandro D'Apice ,  Herbert Bachmann ,  Manfred Wirth ,  Roland Lorenz ,  Tobias Noseda ,  Florian Dold ,  Claudio De Angelis

IPC分类号： F16G1/08

CPC分类号： D07B1/025 ,  D07B1/22 ,  D07B2201/1008 ,  D07B2201/2086 ,  D07B2201/2087 ,  D07B2205/2042 ,  D07B2205/205 ,  D07B2501/2007 ,  D07B2801/10

摘要： A supporting and drive belt including a belt body or sheathing which encloses tensile carriers. The running surface of the belt can be flat and parallel to the belt back or have trapezium-shaped or semicircular ribs and grooves, wherein the profile of a drive pulley or of a deflecting pulley is approximately complementary to the running surface of the belt. One or more tensile carriers are provided for each rib, wherein the tensile carriers are laid or stranded alternately in the “Z” direction and the “S” direction.

摘要翻译： 包括带体或护套的支撑和传动带，其包围拉伸载体。 带的运行表面可以是扁平的并且平行于皮带背部，或者具有梯形或半圆形的肋和凹槽，其中驱动滑轮或偏转滑轮的轮廓与皮带的运行表面大致互补。 为每个肋提供一个或多个拉伸载体，其中拉伸载体交替地在“Z”方向和“S”方向上铺设或绞合。

公开(公告)号：US07578035B2

公开(公告)日：2009-08-25

申请号：US11459162

申请日：2006-07-21

申请人： Florian Dold ,  Adolf Bissig ,  Manfred Wirth ,  Claudio De Angelis

发明人： Florian Dold ,  Adolf Bissig ,  Manfred Wirth ,  Claudio De Angelis

IPC分类号： F16G11/00 ,  F16G11/04

CPC分类号： B66B7/062 ,  Y10T24/3969

摘要： In an elevator installation, an apparatus and a method use a support end connection for fastening a support device to an elevator car, a counterweight and/or a building. The support device has at least one cable or cable strand enclosed by a cable casing and is held in a wedge pocket by a wedge. The cable casing is formed of thermoplastic material or an elastomer and the cable or the cable strand is glued to, fused together with or mechanically connected with the cable casing in the region of the support end connection. A friction force transmitted from the support end connection to the cable casing can then be directly passed on to the load-bearing core of the support device, to the cables or to the cable strands. The tolerable tension force in the support device is increased. The support device is preferably a multiple cable.

摘要翻译： 在电梯安装中，装置和方法使用支撑端连接来将支撑装置紧固到电梯轿厢，配重和/或建筑物。 支撑装置具有由电缆壳体包围的至少一个电缆或电缆线束，并通过楔块保持在楔形凹槽中。 电缆壳体由热塑性材料或弹性体形成，并且电缆或电缆股线在支撑端连接的区域中胶合并与电缆壳体熔合在一起或与电缆壳体机械连接。 然后可以将从支撑端连接传递到电缆壳体的摩擦力直接传递到支撑装置的承载芯，电缆或电缆股线上。 支撑装置中的容许张力增加。 支撑装置优选为多根电缆。