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公开(公告)号：US08697358B2
公开(公告)日：2014-04-15
申请号：US13516070
申请日：2010-12-15
Applicant: Manfred Wirth , Susanne Fuessel , Rainer Koch
Inventor： Manfred Wirth , Susanne Fuessel , Rainer Koch
CPC classification number: C12Q1/6886 , C12Q2600/158
Abstract: The present invention relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer comprising the analysis of the expression of the marker gene hepsin in an urine sample. It further relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer by determining the expression levels of the marker genes hepsin, EZH2, prostein and PCA3.
Abstract translation: 本发明涉及用于诊断前列腺癌的非侵入性方法和/或评估获得前列腺癌的受试者的风险，其包括对尿样中标记基因hepsin的表达的分析。 它还涉及用于诊断前列腺癌的非侵入性方法和/或通过确定标记基因hepsin，EZH2，prostein和PCA3的表达水平来评估获得前列腺癌的受试者的风险。
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2.发明申请PROCESS FOR PRODUCING A TISSUE TRANSPLANT CONSTRUCT FOR RECONSTRUCTING A HUMAN OR ANIMAL ORGAN 审中-公开生产用于重组人类或动物组织的组织运输结构的方法公开(公告)号：US20110081721A1
公开(公告)日：2011-04-07
申请号：US12941756
申请日：2010-11-08
Applicant: Gouya Ram-Liebig , Ursula Ravens , Manfred Wirth
Inventor： Gouya Ram-Liebig , Ursula Ravens , Manfred Wirth
IPC: C12N5/071
CPC classification number: A61L27/3895 , A61L27/3826 , A61L27/3882 , A61L27/50 , A61L2430/22
Abstract: A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught.
Abstract translation: 一种用于生产用于重建人或动物器官的组织移植构建体的方法。 该方法可以包括以下步骤：（a）器官特异性组织细胞的分离和二维培养; （b）将器官特异性组织细胞施用于生物相容的含胶原的膜; 和（c）用器官特异性组织细胞的生化和机械刺激培养膜上的器官特异性组织细胞。 还教导了组织移植结构和使用组织移植构建体的方法。
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3.发明申请PREVASCULARIZED TISSUE TRANSPLANT CONSTRUCTS FOR THE RECONSTRUCTION OF A HUMAN OR ANIMAL ORGAN 审中-公开用于重建人类或动物组织的预组织组织运输结构公开(公告)号：US20100184220A1
公开(公告)日：2010-07-22
申请号：US12280916
申请日：2007-02-28
Applicant: Gouya Ram-Liebig , Manfred Wirth
Inventor： Gouya Ram-Liebig , Manfred Wirth
IPC: C12N5/071
CPC classification number: A61L27/3895 , A61L27/3808 , A61L27/3882 , A61L2430/22 , C12N5/069 , C12N5/0692 , C12N5/0697
Abstract: The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ. Here said tissue transplant construct is intended to comprise(a) a biocompatible acellular membrane and (b) microvascular endothelial cells which penetrate the membrane, wherein microvascular structures of microvascular endothelial cells are formed within the membrane.
Abstract translation: 本发明涉及用于重建人或动物器官的组织移植构建体。 这里所述的组织移植构建物旨在包括（a）生物相容的无细胞膜和（b）穿透膜的微血管内皮细胞，其中在膜内形成微血管内皮细胞的微血管结构。
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公开(公告)号：US08632432B2
公开(公告)日：2014-01-21
申请号：US11863596
申请日：2007-09-28
Applicant: Adolf Bissig , Alessandro D'Apice , Herbert Bachmann , Manfred Wirth , Roland Lorenz , Tobias Noseda , Florian Dold , Claudio De Angelis
Inventor： Adolf Bissig , Alessandro D'Apice , Herbert Bachmann , Manfred Wirth , Roland Lorenz , Tobias Noseda , Florian Dold , Claudio De Angelis
IPC: F16G1/08
CPC classification number: D07B1/025 , D07B1/22 , D07B2201/1008 , D07B2201/2086 , D07B2201/2087 , D07B2205/2042 , D07B2205/205 , D07B2501/2007 , D07B2801/10
Abstract: A supporting and drive belt including a belt body or sheathing which encloses tensile carriers. The running surface of the belt can be flat and parallel to the belt back or have trapezium-shaped or semicircular ribs and grooves, wherein the profile of a drive pulley or of a deflecting pulley is approximately complementary to the running surface of the belt. One or more tensile carriers are provided for each rib, wherein the tensile carriers are laid or stranded alternately in the “Z” direction and the “S” direction.
Abstract translation: 包括带体或护套的支撑和传动带，其包围拉伸载体。 带的运行表面可以是扁平的并且平行于皮带背部，或者具有梯形或半圆形的肋和凹槽，其中驱动滑轮或偏转滑轮的轮廓与皮带的运行表面大致互补。 为每个肋提供一个或多个拉伸载体，其中拉伸载体交替地在“Z”方向和“S”方向上铺设或绞合。
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5.发明授权Support means end connection for fastening an end of a support means in an elevator installation, an elevator installation with a support means end connection, and a method for fastening an end of a support means in an elevator installation 有权支撑装置用于紧固电梯装置中的支撑装置的端部的终端连接，具有支撑装置端部连接的电梯装置以及用于将电梯装置中的支撑装置的一端紧固的方法公开(公告)号：US07578035B2
公开(公告)日：2009-08-25
申请号：US11459162
申请日：2006-07-21
Applicant: Florian Dold , Adolf Bissig , Manfred Wirth , Claudio De Angelis
Inventor： Florian Dold , Adolf Bissig , Manfred Wirth , Claudio De Angelis
CPC classification number: B66B7/062 , Y10T24/3969
Abstract: In an elevator installation, an apparatus and a method use a support end connection for fastening a support device to an elevator car, a counterweight and/or a building. The support device has at least one cable or cable strand enclosed by a cable casing and is held in a wedge pocket by a wedge. The cable casing is formed of thermoplastic material or an elastomer and the cable or the cable strand is glued to, fused together with or mechanically connected with the cable casing in the region of the support end connection. A friction force transmitted from the support end connection to the cable casing can then be directly passed on to the load-bearing core of the support device, to the cables or to the cable strands. The tolerable tension force in the support device is increased. The support device is preferably a multiple cable.
Abstract translation: 在电梯安装中，装置和方法使用支撑端连接来将支撑装置紧固到电梯轿厢，配重和/或建筑物。 支撑装置具有由电缆壳体包围的至少一个电缆或电缆线束，并通过楔块保持在楔形凹槽中。 电缆壳体由热塑性材料或弹性体形成，并且电缆或电缆股线在支撑端连接的区域中胶合并与电缆壳体熔合在一起或与电缆壳体机械连接。 然后可以将从支撑端连接传递到电缆壳体的摩擦力直接传递到支撑装置的承载芯，电缆或电缆股线上。 支撑装置中的容许张力增加。 支撑装置优选为多根电缆。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20090041822A1
公开(公告)日：2009-02-12
申请号：US11572956
申请日：2005-07-18
Applicant: Gouya Ram-Liebig , Oliver Hakenberg , Manfred Wirth
Inventor： Gouya Ram-Liebig , Oliver Hakenberg , Manfred Wirth
CPC classification number: A61L27/3804 , A61K35/38 , A61L27/3604 , A61L27/3641 , A61L27/3839 , A61L2430/22
Abstract: The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ, where the tissue transplant construct comprises: a) a biologically compatible, collagen-containing membrane, and b) one or more layers of organ-specific tissue cells on the membrane, and where the outermost layer of the organ-specific tissue cells is a layer of terminally differentiated organ-specific tissue cells.
Abstract translation: 本发明涉及用于重组人或动物器官的组织移植构建体，其中组织移植构建体包含：a）生物相容的含胶原的膜，和b）一层或多层器官特异性组织细胞 膜，并且其中器官特异性组织细胞的最外层是终末分化的器官特异性组织细胞的层。
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公开(公告)号：US20080081721A1
公开(公告)日：2008-04-03
申请号：US11863596
申请日：2007-09-28
Applicant: Adolf Bissig , Alessandro D'Apice , Herbert Bachmann , Manfred Wirth , Roland Lorenz , Tobias Noseda , Florian Dold , Claudio De Angelis
Inventor： Adolf Bissig , Alessandro D'Apice , Herbert Bachmann , Manfred Wirth , Roland Lorenz , Tobias Noseda , Florian Dold , Claudio De Angelis
IPC: F16G1/08
CPC classification number: D07B1/025 , D07B1/22 , D07B2201/1008 , D07B2201/2086 , D07B2201/2087 , D07B2205/2042 , D07B2205/205 , D07B2501/2007 , D07B2801/10
Abstract: A supporting and drive belt including a belt body or sheathing which encloses tensile carriers. The running surface of the belt can be flat and parallel to the belt back or have trapezium-shaped or semicircular ribs and grooves, wherein the profile of a drive pulley or of a deflecting pulley is approximately complementary to the running surface of the belt. One or more tensile carriers are provided for each rib, wherein the tensile carriers are laid or stranded alternately in the “Z” direction and the “S” direction.
Abstract translation: 包括带体或护套的支撑和传动带，其包围拉伸载体。 带的运行表面可以是扁平的并且平行于皮带背部，或者具有梯形或半圆形的肋和凹槽，其中驱动滑轮或偏转滑轮的轮廓与皮带的运行表面大致互补。 为每个肋提供一个或多个拉伸载体，其中拉伸载体交替地在“Z”方向和“S”方向上铺设或绞合。
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8.发明申请SYNTHETIC FIBER CABLE AND ELEVATOR INSTALLATION WITH SUCH A SYNTHETIC FIBER CABLE 有权合成纤维电缆和电梯与这种合成纤维电缆的安装公开(公告)号：US20080078157A1
公开(公告)日：2008-04-03
申请号：US11863401
申请日：2007-09-28
Applicant: Florian Dold , Adolf Bissig , Alessandro D'Apice , Herbert Bachmann , Manfred Wirth , Tobias Noseda , Roland Lorenz , Claudio De Angelis
Inventor： Florian Dold , Adolf Bissig , Alessandro D'Apice , Herbert Bachmann , Manfred Wirth , Tobias Noseda , Roland Lorenz , Claudio De Angelis
IPC: D02G3/36
CPC classification number: D07B1/162 , B66B7/06 , B66B7/062 , D07B1/025 , D07B1/22 , D07B2201/1008 , D07B2205/2042 , D07B2205/205 , D07B2501/2007 , D07B2801/10
Abstract: A synthetic fiber cable has the strands of a strand layer mutually spaced apart. With the mutual spacing, the strands of the outer strand layer can move radially in the direction of the cable center and exert a radial pressure on the strands of the first inner strand layer. The radial pressure is passed on from the strands of the first inner strand layer to the strands of the second inner strand layer. The radial pressure is passed on from the strands of the second inner strand layer to the core strand. The radial pressure increases inwardly from strand layer to strand layer. The soft cable sheathing does not act as a support between the strands in circumferential direction.
Abstract translation: 合成纤维电缆具有相互隔开的绞线层的绞线。 通过相互间隔，外股线层的股线可沿电缆中心的方向径向移动，并在第一内股线层的股线上施加径向压力。 径向压力从第一内股层的股线传递到第二内股层的股线。 径向压力从第二内股层的股线传递到芯股。 径向压力从绞线层向绞线层向内增加。 软电缆护套不作为沿圆周方向的股线之间的支撑。
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9.发明申请Process for producing a tissue transplant construct for reconstructing a human or animal organ 有权用于生产用于重建人或动物器官的组织移植构建体的方法公开(公告)号：US20060233767A1
公开(公告)日：2006-10-19
申请号：US11364486
申请日：2006-02-28
Applicant: Gouya Ram-Liebig , Ursula Ravens , Manfred Wirth
Inventor： Gouya Ram-Liebig , Ursula Ravens , Manfred Wirth
CPC classification number: A61L27/3895 , A61L27/3826 , A61L27/3882 , A61L27/50 , A61L2430/22
Abstract: A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught.
Abstract translation: 一种用于生产用于重建人或动物器官的组织移植构建体的方法。 该方法可以包括以下步骤：（a）器官特异性组织细胞的分离和二维培养; （b）将器官特异性组织细胞施用于生物相容的含胶原的膜; 和（c）用器官特异性组织细胞的生化和机械刺激培养膜上的器官特异性组织细胞。 还教导了组织移植结构和使用组织移植构建体的方法。
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公开(公告)号：US20060127909A1
公开(公告)日：2006-06-15
申请号：US10537449
申请日：2003-12-08
Applicant: Bernd Schwenzer , Uta Schmidt , Manfred Wirth , Kai Kramer , Susanne Fussel , Axel Meye
Inventor： Bernd Schwenzer , Uta Schmidt , Manfred Wirth , Kai Kramer , Susanne Fussel , Axel Meye
CPC classification number: C12N9/1241
Abstract: The present invention relates to polynucleotides directed towards a gene of a catalytic subunit of human telomerase, as well as to the use of said polynucleotides for the diagnosis, prophylaxis, reduction and follow-up of diseases associated with cell growth, differentiation and/or division, such as tumor diseases.
Abstract translation: 本发明涉及针对人类端粒酶的催化亚基的基因的多核苷酸，以及所述多核苷酸用于诊断，预防，减少和跟踪与细胞生长，分化和/或分裂相关疾病的用途 ，如肿瘤疾病。
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