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公开(公告)号：US5866113A
公开(公告)日：1999-02-02
申请号：US813470
申请日：1997-03-07
IPC分类号： A61L31/00 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/12 , C08J7/00 , A61K31/765 , A61K31/78 , A61L27/00 , C08L33/02
CPC分类号： A61L33/128 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/044 , A61L29/085 , A61L29/16 , A61L31/043 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L33/0041 , A61L33/0076 , A61L33/0088 , A61L2300/00 , Y10S530/815 , Y10S530/816
摘要： A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
摘要翻译： 一种具有包含位于所述装置上的羧基官能团的表面接枝基质的医疗装置，所述表面移植物基质包含外部部分; 共价偶联到表面接枝基质上的一种或多种生物分子，其中大部分生物分子位于表面移植物基质的外部。 表面接枝基质也可以加载药剂。
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公开(公告)号：US5811151A
公开(公告)日：1998-09-22
申请号：US656614
申请日：1996-05-31
IPC分类号： A61L31/00 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/12 , C08J7/00 , B05D3/00
CPC分类号： A61L33/128 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/044 , A61L29/085 , A61L29/16 , A61L31/043 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L33/0041 , A61L33/0076 , A61L33/0088 , A61L2300/00 , Y10S530/815 , Y10S530/816
摘要： A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
摘要翻译： 一种具有包含位于所述装置上的羧基官能团的表面接枝基质的医疗装置，所述表面移植物基质包含外部部分; 共价偶联到表面接枝基质上的一种或多种生物分子，其中大部分生物分子位于表面移植物基质的外部。 表面接枝基质也可以加载药剂。
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公开(公告)号：US5679659A
公开(公告)日：1997-10-21
申请号：US518084
申请日：1995-08-22
IPC分类号： A61L33/10 , A61L33/00 , A61K31/725 , C08B37/10
CPC分类号： A61L33/0011 , A61L33/0023 , A61L33/0029 , Y10S623/921
摘要： An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH in the range of about 4.5-8. This mixture is reacted for at least 3 hours while protected from light and is then applied to the immobilized amine groups. This is an improvement over the prior art methods which included using an excess of periodate and then stopping the reaction at a desired point by the addition of glycerol since the conversion of only a few of the natural functional groups to aldehydes better preserves the antithrombotic bioeffectiveness of the heparin molecules bound to the surface. The invention also avoids the prior art steps of drying and reconstituting the heparin by providing a reacted mixture of heparin and periodate that can be stored as a stable liquid and applied directly to the aminated surface several days later.
摘要翻译： 在血液接触表面上制备具有固定化肝素的医疗装置的改进方法，其中将肝素与足够的高碘酸盐混合以在pH为约4.5的缓冲溶液中每个肝素分子与不超过两个糖单元反应 -8。 将该混合物反应至少3小时，同时保护光，然后将其施加到固定的胺基上。 这是相对于现有技术的方法的改进，其包括使用过量的高碘酸盐，然后通过加入甘油在期望点停止反应，因为仅将少数天然官能团转化为醛更好地保持抗血栓生物效力 肝素分子与表面结合。 本发明还避免了通过提供肝素和高碘酸盐的反应混合物来干燥和重构肝素的现有技术步骤，其可以作为稳定液体储存并在几天后直接施用于胺化表面。
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公开(公告)号：US5782908A
公开(公告)日：1998-07-21
申请号：US748991
申请日：1996-11-14
CPC分类号： A61L33/0047 , A61L27/28 , A61L27/34 , A61L31/10 , A61L33/0029 , Y10S623/924
摘要： A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
摘要翻译： 具有金属或玻璃表面的医疗制品，其表面具有改进的生物相容性的粘附涂层。 通过首先向表面施加具有侧链乙烯基官能团的硅烷化合物，使得硅烷粘附到表面，然后在单独的步骤中，用所施加的乙烯基硅烷在表面上形成接枝聚合物，使得侧链乙烯基官能度 的乙烯基硅烷通过与聚合物共价键结合到接枝聚合物中。 然后可以将生物分子共价连接到基层。
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公开(公告)号：US5672638A
公开(公告)日：1997-09-30
申请号：US517788
申请日：1995-08-22
CPC分类号： A61L33/0029 , Y10S623/924
摘要： An improved coating and spacer material for a medical device having a blood or tissue-contacting surface comprising a polyalkyleneimine layer which is crosslinked with a crosslinking agent which is at least difunctional in polymerizable vinyl groups which have adjacent strong electron-withdrawing groups and a biomolecule covalently bonded to the crosslinked polyalkyleneimine layer. For example, polyethyleneimine crosslinked with divinyl sulfone could be used. The resulting crosslinked spacer layer has improved uniformity and stability without materially limiting the covalent attachment of a biomolecule such as heparin.
摘要翻译： 一种用于具有血液或组织接触表面的医疗装置的改进的涂层和间隔物材料，其包含聚亚烷基亚胺层，所述聚亚烷基亚胺层与交联剂交联，所述交联剂在具有相邻强吸电子基团的可聚合乙烯基中具有至少双官能度，并且共价生物分子 与交联的聚亚烷基亚胺层结合。 例如，可以使用与二乙烯基砜交联的聚亚乙基亚胺。 所得的交联间隔层具有改善的均匀性和稳定性，而不会实质上限制生物分子如肝素的共价连接。
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公开(公告)号：US5607475A
公开(公告)日：1997-03-04
申请号：US518129
申请日：1995-08-22
CPC分类号： A61L33/0047 , A61L27/28 , A61L27/34 , A61L31/10 , A61L33/0029 , Y10S623/924
摘要： A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
摘要翻译： 具有金属或玻璃表面的医疗制品，其表面具有改进的生物相容性的粘附涂层。 通过首先向表面施加具有侧链乙烯基官能团的硅烷化合物，使得硅烷粘附到表面，然后在单独的步骤中，用所施加的乙烯基硅烷在表面上形成接枝聚合物，使得侧链乙烯基官能度 的乙烯基硅烷通过与聚合物共价键结合到接枝聚合物中。 然后可以将生物分子共价连接到基层。
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公开(公告)号：US5741319A
公开(公告)日：1998-04-21
申请号：US379423
申请日：1995-01-27
CPC分类号： A61N1/0556
摘要： A medical lead having a lead body and a biocompatible cuff and especially suitable for use as a nerve electrode. In the preferred bipolar embodiment the lead body has two conductors running therethrough. The distal end is coupled to a pulse generator, the proximal end is coupled to the biocompatible cuff. The biocompatible cuff is cylindrical and is constructed from collagen. Preferably the collagen is multi-layer, i.e. the first portion is cross-linked to an amount greater than the second portion. Through such a construction the collagen promotes tissue ingrowth in the region proximate a nerve and does not permit tissue ingrowth in the region away from the nerve, e.g. the exterior of the cuff.
摘要翻译： 一种具有铅体和生物相容性袖带的医用铅，特别适用于神经电极。 在优选的双极实施例中，引线体具有穿过其中的两个导体。 远端连接到脉冲发生器，近端连接到生物相容的袖带。 生物相容的袖口是圆柱形的，由胶原构成。 优选地，胶原蛋白是多层的，即第一部分交联到大于第二部分的量。 通过这样的结构，胶原蛋白促进组织在靠近神经的区域向内生长，并且不允许组织向远离神经的区域向内生长，例如， 袖口的外观。
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公开(公告)号：US5702818A
公开(公告)日：1997-12-30
申请号：US430001
申请日：1995-04-27
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基亚胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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公开(公告)号：US5415938A
公开(公告)日：1995-05-16
申请号：US193964
申请日：1994-02-09
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkyaimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基亚胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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公开(公告)号：US5308641A
公开(公告)日：1994-05-03
申请号：US6218
申请日：1993-01-19
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylizine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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