公开(公告)号：US20060247197A1

公开(公告)日：2006-11-02

申请号：US11396926

申请日：2006-04-03

申请人： Marc Van De Craen ,  Phuay-Yee Goh ,  Marc Logghe ,  Yee-Ling Khu ,  Katherine Mortier ,  Thierry Bogaert

发明人： Marc Van De Craen ,  Phuay-Yee Goh ,  Marc Logghe ,  Yee-Ling Khu ,  Katherine Mortier ,  Thierry Bogaert

IPC分类号： A61K48/00 ,  C12N15/74 ,  A01N43/04

CPC分类号： A01N57/16 ,  A01N63/02 ,  A01N63/04 ,  C07K14/37 ,  C12N15/113 ,  C12N15/8218 ,  C12N15/8282 ,  C12N2310/14

摘要： The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.

摘要翻译： 本发明涉及通过dsRNA介导的基因沉默来控制真菌感染的方法，其中完整的真菌细胞与来自真菌细胞外的双链RNA接触，由此双链RNA被 完整的真菌细胞。 在一个具体实施方案中，本发明的方法用于减轻植物从真菌害虫中的减少。 或者，所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的真菌侵袭。 公开了合适的真菌靶基因及其片段，dsRNA构建体，重组构建体和组合物。

公开(公告)号：US20070092910A1

公开(公告)日：2007-04-26

申请号：US10561098

申请日：2004-06-17

申请人： Gert De Wilde ,  Michael Saunders ,  Marc Logghe

发明人： Gert De Wilde ,  Michael Saunders ,  Marc Logghe

IPC分类号： C40B30/06 ,  C07H21/04 ,  C12P21/06 ,  C07K16/28 ,  C07K14/705

CPC分类号： C12N9/0006

摘要： The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences—such as proteins and/or polypeptides—that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly those set out in SEQ ID NO's 1, 6 and 8. The invention further relates to genetic constructs, host cells and organisms that have been transformed with the nucleotide sequences of the invention and that can express the amino acid sequences of the invention and methods and compositions which utilize the nucleotide and amino acid sequences of the invention.

摘要翻译： 本发明涉及编码并可用于表达可用于鉴定和开发用于预防和治疗代谢性疾病的化合物的氨基酸序列的核苷酸序列，特别是SEQ ID NO：2,7和9的核苷​​酸序列， 糖尿病和肥胖。 本发明还涉及由本发明的核苷酸序列，特别是SEQ ID NO：1中列出的那些的核苷酸序列编码并且可以通过适当表达获得的氨基酸序列 - 例如蛋白质和/或多肽 - 本发明还涉及已经用本发明的核苷酸序列转化并可以表达本发明的氨基酸序列的遗传构建体，宿主细胞和生物体，以及利用核苷酸和氨基酸序列的方法和组合物 的本发明。

公开(公告)号：US20070010448A1

公开(公告)日：2007-01-11

申请号：US11519693

申请日：2006-09-12

申请人： Roland Contreras ,  Bart Nelissen ,  Marianne De Backer ,  Walter Luyten ,  Jasmine Viaene ,  Marc Logghe ,  Jorge Vialard

发明人： Roland Contreras ,  Bart Nelissen ,  Marianne De Backer ,  Walter Luyten ,  Jasmine Viaene ,  Marc Logghe ,  Jorge Vialard

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/74 ,  C12N1/18 ,  C07K14/40

CPC分类号： C07K14/40 ,  A61K38/00

摘要： The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.

摘要翻译： 本发明涉及鉴定对于生长和细胞分裂至关重要的白色念珠菌的基因或其功能片段，哪些基因可用作治疗白色念珠菌相关感染的选择性药物靶标。 还提供了来自白色念珠菌的新型核酸序列，其编码对白色念珠菌生长至关重要的多肽。 还考虑了用于鉴定抑制真菌或酵母生长的抗真菌化合物的方法。

公开(公告)号：US20120131687A1

公开(公告)日：2012-05-24

申请号：US13120496

申请日：2009-09-24

申请人： Junko Otsuki ,  Marc Logghe ,  Titus Kaletta ,  Wendy Maddelein

发明人： Junko Otsuki ,  Marc Logghe ,  Titus Kaletta ,  Wendy Maddelein

IPC分类号： G01N21/75 ,  C07K14/435 ,  C07C211/63 ,  A01N33/12 ,  C07C309/30 ,  A01P5/00 ,  A01P7/04 ,  A01P7/02 ,  A01K67/033 ,  C12P19/34 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C12P21/02 ,  G01N27/00 ,  G09G5/00 ,  C12N15/12

CPC分类号： C07K14/43563 ,  G01N33/5085 ,  G01N33/6872 ,  G01N2500/10

摘要： The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect voltage-gated potassium channel; a method for assaying pesticidal activity of a test substance, which comprises measuring the activity of a voltage-gated potassium channel in a reaction system in which the voltage-gated potassium channel contacts with a test substance, and so on.

摘要翻译： 本发明提供调节害虫生理状态的药剂，其中该药剂具有调节昆虫电压门控钾通道活性的能力; 测定被检物质的杀虫活性的方法，该方法包括测定电压门控钾通道与测试物质接触的反应系统中的电压门控钾通道的活性等。