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    Tetrahydropyridines, preparation method and pharmaceutical compositions containing same
    1.
    发明授权
    Tetrahydropyridines, preparation method and pharmaceutical compositions containing same 失效
    四氢吡啶类，制备方法和含有它们的药物组合物

    公开(公告)号：US06689797B2

    公开(公告)日：2004-02-10

    申请号：US10169528

    申请日：2002-10-15

    申请人： Marco Baroni ,  Bernard Bourrie ,  Rosanna Cardamone ,  Pierre Casellas

    发明人： Marco Baroni ,  Bernard Bourrie ,  Rosanna Cardamone ,  Pierre Casellas

    IPC分类号： A61K3144

    CPC分类号： C07D405/06 ,  C07D409/06

    摘要： The present invention relates to compounds of formula (I): in which R1 represents a hydrogen or halogen atom, or a group CF3; R2 and R3 represent, independently, a hydrogen atom or a methyl group; n and n′ each represent, independently, 0 or 1; * represents the positions of attachment; A represents N or CH; X represents a sulfur or oxygen atom; R4 and R5 represent, independently, a hydrogen atom or a (C1-C6) alkyl group; and also their salts or solvates, to a method for the preparation thereof and to the pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1表示氢或卤素原子或基团CF 3; R 2和R 3独立地表示氢原子或甲基; n和n'各自独立地表示， 0或1; *表示连接位置; A表示N或CH; X表示硫或氧原子; R4和R5独立地表示氢原子或（C1-C6）烷基;以及它们的盐或 溶剂合物，其制备方法和含有它们的药物组合物。

    Phenyl- and pyridylpiperidines with TNF activity
    6.
    发明授权
    Phenyl- and pyridylpiperidines with TNF activity 失效
    具有TNF活性的苯基和吡啶基哌啶

    公开(公告)号：US07326720B2

    公开(公告)日：2008-02-05

    申请号：US10475272

    申请日：2002-04-19

    申请人： Marco Baroni ,  Bernard Bourrie ,  Pierre Casellas

    发明人： Marco Baroni ,  Bernard Bourrie ,  Pierre Casellas

    IPC分类号： A61K31/4523 ,  A61K31/4545 ,  C07D211/06 ,  C07D211/08

    CPC分类号： C07D401/06

    摘要： The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a condensed heterocyclic group of formula (w) where W completes an aromatic or saturated 6-membered ring system comprising one or two nitrogen atoms or else an aromatic or saturated 5-membered ring system comprising a nitrogen, oxygen or sulfur atom which are optionally substituted, and to their N-oxides and to their salts or solvates, to the pharmaceutical compositions and the medicaments comprising them and to a process for their preparation.

    摘要翻译： 本发明涉及式（I）化合物：其中X表示N或CH; R 1表示氢或卤素原子或CF 3 N 3基团; R 2和R 3独立地表示氢原子或甲基; n为0或1; A表示式（w）的稠合杂环基，其中W完成包含一个或两个氮原子的芳族或饱和的6-元环系统，或包含氮，氧或硫原子的芳族或饱和五元环系统， 任选取代，并且与它们的N-氧化物及其盐或溶剂合物相关的药物组合物和包含它们的药物及其制备方法。