Modulators of leukocyte activation, BIC compositions and methods of use
    2.
    发明授权
    Modulators of leukocyte activation, BIC compositions and methods of use 有权
    白细胞激活调节剂,BIC组合物和使用方法

    公开(公告)号:US06929923B2

    公开(公告)日:2005-08-16

    申请号:US10202480

    申请日:2002-07-23

    IPC分类号: C07K14/705 G01N33/68 C12Q1/02

    摘要: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

    摘要翻译: 本发明提供了调节白细胞活化的组合物和方法。 提供编码能够调节白细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

    Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use
    3.
    发明授权
    Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use 有权
    B淋巴细胞活化的调节剂,肌球蛋白-1F组合物和使用方法

    公开(公告)号:US06890725B2

    公开(公告)日:2005-05-10

    申请号:US10202481

    申请日:2002-07-23

    摘要: The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating B-lymphocyte activation.

    摘要翻译: 本发明提供用于调节B-淋巴细胞活化的组合物和方法。 提供编码能够调节B淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节B-淋巴细胞活化的生物活性剂的测定法。

    Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use
    4.
    发明授权
    Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use 有权
    B淋巴细胞活化的调节剂,肌球蛋白-1F组合物和使用方法

    公开(公告)号:US07371537B2

    公开(公告)日:2008-05-13

    申请号:US11116725

    申请日:2005-04-27

    IPC分类号: C02K1/00 G01N33/53

    摘要: The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating B-lymphocyte activation.

    摘要翻译: 本发明提供用于调节B-淋巴细胞活化的组合物和方法。 提供编码能够调节B淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节B-淋巴细胞活化的生物活性剂的测定法。

    Modulators of leukocyte activation, Hck compositions and methods of use
    5.
    发明授权
    Modulators of leukocyte activation, Hck compositions and methods of use 有权
    白细胞激活的调节剂,Hck组合物和使用方法

    公开(公告)号:US07067266B2

    公开(公告)日:2006-06-27

    申请号:US10193720

    申请日:2002-07-10

    IPC分类号: C12Q1/02 C12Q1/48 G01N33/566

    摘要: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

    摘要翻译: 本发明提供了调节白细胞活化的组合物和方法。 提供编码能够调节白细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。