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公开(公告)号：US08440436B2
公开(公告)日：2013-05-14
申请号：US12669955
申请日：2008-07-21
摘要： The invention relates to the production of itaconic acid in micro-organisms by introducting into a suitable host cell a gene coding for the enzyme cis-aconitic acid decarboxylase, preferably derived from A. terreus. Further part of the invention are host cells, preferably from A. niger, provided with the above mentioned genes.
摘要翻译： 本发明涉及通过向合适的宿主细胞中引入编码优选来源于土曲霉的顺式乌头酸脱羧酶的基因而在微生物中生产衣康酸。 本发明的另一部分是具有上述基因的宿主细胞，优选来自黑曲霉。
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公开(公告)号：US20100311132A1
公开(公告)日：2010-12-09
申请号：US12669955
申请日：2008-07-21
摘要： The invention relates to the production of itaconic acid in micro-organisms by introducting into a suitable host cell a gene coding for the enzyme cis-aconitic acid decarboxylase, preferably derived from A. terreus. Further part of the invention are host cells, preferably from A. niger, provided with the above mentioned genes.
摘要翻译： 本发明涉及通过向合适的宿主细胞中引入编码优选来源于土曲霉的顺式乌头酸脱羧酶的基因而在微生物中生产衣康酸。 本发明的另一部分是具有上述基因的宿主细胞，优选来自黑曲霉。
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公开(公告)号：US08642298B2
公开(公告)日：2014-02-04
申请号：US12920461
申请日：2009-03-04
摘要： The invention relates to a nucleic acid sequence encoding an itaconate transporting Major Facilitator Superfamily Transporter (MFST) gene sequence and the protein encoded thereby. Preferably said sequence is the nucleic acid that comprises the sequence of ATEG_09972.1 of Aspergillus terreus or homologues thereof. Overexpression of the protein enhances the production of itaconic acid in microorganisms.
摘要翻译： 本发明涉及编码衣康酸输送主要促进剂超家族转运蛋白（MFST）基因序列的核酸序列和由此编码的蛋白质。 优选地，所述序列是包含Aspergillus terreus的ATEG_09972.1或其同系物的序列的核酸。 蛋白质的过表达增强了微生物中衣康酸的生成。
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公开(公告)号：US08679801B2
公开(公告)日：2014-03-25
申请号：US12918314
申请日：2009-02-16
摘要： The invention relates to a nucleic acid sequence encoding an Aspergillus mitochondrial tricarboxylic acid transporter that can be used in the production of itaconic acid in micro-organisms. Preferably said transporter protein is the protein encoded by the nucleic acid which is located on a chromosome segment of A. terreus that also harbors other genes involved in the itaconic acid biosynthesis and the lovastatin biosynthesis. Also, vectors, hosts and transformed micro-organisms are part of the invention.
摘要翻译： 本发明涉及编码可用于微生物中衣康酸生产的曲霉线粒体三羧酸转运蛋白的核酸序列。 所述转运蛋白优选是由位于A.rereus的染色体片段上的核酸编码的蛋白，其还含有参与衣康酸生物合成和洛伐他汀生物合成的其它基因。 而且，载体，宿主和转化的微生物是本发明的一部分。
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公开(公告)号：US20110124066A1
公开(公告)日：2011-05-26
申请号：US12918314
申请日：2009-02-16
摘要： The invention relates to a nucleic acid sequence encoding an Aspergillus mitochondrial tricarboxylic acid transporter that can be used in the production of itaconic acid in micro-organisms. Preferably said transporter protein is the protein encoded by the nucleic acid which is located on a chromosome segment of A. terreus that also harbours other genes involved in the itaconic acid biosynthesis and the lovastatin biosynthesis. Also, vectors, hosts and transformed micro-organisms are part of the invention.
摘要翻译： 本发明涉及编码可用于微生物中衣康酸生产的曲霉线粒体三羧酸转运蛋白的核酸序列。 所述转运蛋白优选是由位于A.rereus的染色体片段上的核酸编码的蛋白，其还含有参与衣康酸生物合成和洛伐他汀生物合成的其它基因。 而且，载体，宿主和转化的微生物是本发明的一部分。
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公开(公告)号：US20110070616A1
公开(公告)日：2011-03-24
申请号：US12920461
申请日：2009-03-04
摘要： The invention relates to a nucleic acid sequence encoding an itaconate transporting Major Facilitator Superfamily Transporter (MFST) gene sequence and the protein encoded thereby. Preferably said sequence is the nucleic acid that comprises the sequence of ATEG_09972.1 of Aspergillus terreus or homologues thereof. Overexpression of the protein enhances the production of itaconic acid in micro-organisms.
摘要翻译： 本发明涉及编码衣康酸输送主要促进剂超家族转运蛋白（MFST）基因序列的核酸序列和由此编码的蛋白质。 优选地，所述序列是包含Aspergillus terreus的ATEG_09972.1或其同系物的序列的核酸。 蛋白质的过表达增强了微生物中衣康酸的生成。
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