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公开(公告)号:US20080255152A1
公开(公告)日:2008-10-16
申请号:US12052994
申请日:2008-03-21
申请人: Maria-Jesus Blanco-Pillado , Mark Donald Chappell , Marta Garcia De La Torre , Nuria Diaz Buezo , James Erwin Fritz , William Glen Holloway , James Edward Matt , Charies Howard Mitch , Concepcion Pedregal-Tercero , Steven James Quimby , Miles Goodman Siegel , Dana Rae Smith , Russell Dean Stucky , Kumiko Takeuchi , Elizabeth Marie Thomas , Chad Nolan Wolfe
发明人: Maria-Jesus Blanco-Pillado , Mark Donald Chappell , Marta Garcia De La Torre , Nuria Diaz Buezo , James Erwin Fritz , William Glen Holloway , James Edward Matt , Charies Howard Mitch , Concepcion Pedregal-Tercero , Steven James Quimby , Miles Goodman Siegel , Dana Rae Smith , Russell Dean Stucky , Kumiko Takeuchi , Elizabeth Marie Thomas , Chad Nolan Wolfe
IPC分类号: A61K31/497
CPC分类号: C07D213/643 , C07C235/46 , C07D213/38 , C07D213/64 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D237/24 , C07D239/34 , C07D241/24 , C07D307/14 , C07D307/52 , C07D333/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
摘要翻译: 式(I)的化合物,其中变量X 1至X 10,R 1至R 7, 包括R 3,E,V,Y,Z,A和B如上所述,或其药学上可接受的盐,溶剂合物,对映异构体,外消旋体,非对映体或其混合物,可用于治疗,预防 或改善肥胖及相关疾病。
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公开(公告)号:US20080269296A1
公开(公告)日:2008-10-30
申请号:US12052972
申请日:2008-03-21
申请人: Maria-Jesus Blanco-Pillado , Mark Donald Chappell , Marta Garcia De La Torre , Nuria Diaz Buezo , James Erwin Fritz , William Glen Holloway , James Edward Matt , Charles Howard Mitch , Concepcion Pedregal-Tercero , Steven James Quimby , Miles Goodman Siegel , Dana Rae Smith , Russell Dean Stucky , Kumiko Takeuchi , Elizabeth Marie Thomas , Chad Nolan Wolfe
发明人: Maria-Jesus Blanco-Pillado , Mark Donald Chappell , Marta Garcia De La Torre , Nuria Diaz Buezo , James Erwin Fritz , William Glen Holloway , James Edward Matt , Charles Howard Mitch , Concepcion Pedregal-Tercero , Steven James Quimby , Miles Goodman Siegel , Dana Rae Smith , Russell Dean Stucky , Kumiko Takeuchi , Elizabeth Marie Thomas , Chad Nolan Wolfe
IPC分类号: A61K31/4433 , A61P25/32
CPC分类号: C07D213/643 , C07C235/46 , C07D213/38 , C07D213/64 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D237/24 , C07D239/34 , C07D241/24 , C07D307/14 , C07D307/52 , C07D333/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z. A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
摘要翻译: 式(I)的化合物,其中变量X 1至X 10,R 1至R 7, 包括R 3',E,v,y,z。 A和B如所述,或其药学上可接受的盐,溶剂化物,对映体,外消旋物,非对映异构体或其混合物,其可用于治疗,预防或改善肥胖症和相关疾病。
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3.
公开(公告)号:US08093302B2
公开(公告)日:2012-01-10
申请号:US11814806
申请日:2006-02-10
IPC分类号: A61K31/045 , A61K31/135 , A61K31/05 , A61K31/075 , C07C211/00 , C07C43/02 , C07C43/20 , C07C35/42 , C07C39/12
CPC分类号: C07C49/747 , C07B2200/07 , C07C37/82 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/1788 , C07C43/21 , C07C43/23 , C07C45/292 , C07C45/44 , C07C45/62 , C07C45/673 , C07C45/68 , C07C45/70 , C07C47/277 , C07C47/57 , C07C47/575 , C07C49/577 , C07C49/753 , C07C49/755 , C07C49/83 , C07C49/84 , C07C69/757 , C07C69/94 , C07C205/37 , C07C205/45 , C07C215/64 , C07C217/94 , C07C235/34 , C07C235/66 , C07C247/10 , C07C255/36 , C07C255/53 , C07C2603/16 , C07C2603/26 , C07D295/096 , C07D295/185 , C07D307/92 , C07D311/78 , C07C49/603
摘要: The present invention relates to novel tetralin ER-β agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon cancer, prostate cancer, infertility, depression, leukemia, inflammatory bowel disease, and arthritis.
摘要翻译: 本发明涉及新的四氢萘酮ER-&bgr; 激动剂化合物,其药物组合物,以及这些化合物用于治疗ER- 介导性疾病如夜尿症,阻塞性尿失禁,良性前列腺肥大,肥胖症,痴呆,高血压,失禁,结肠癌,前列腺癌,不育症,抑郁症,白血病,炎性肠病和关节炎。
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4.
公开(公告)号:US20100249075A1
公开(公告)日:2010-09-30
申请号:US11814806
申请日:2006-02-10
IPC分类号: A61K31/05 , C07C35/42 , C07C39/17 , C07D307/92 , C07D211/32 , C07C235/34 , C07D207/08 , A61K31/343 , A61K31/235 , A61K31/192 , A61K31/655 , A61K31/275 , A61K31/445 , A61K31/165 , A61K31/40
CPC分类号: C07C49/747 , C07B2200/07 , C07C37/82 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/1788 , C07C43/21 , C07C43/23 , C07C45/292 , C07C45/44 , C07C45/62 , C07C45/673 , C07C45/68 , C07C45/70 , C07C47/277 , C07C47/57 , C07C47/575 , C07C49/577 , C07C49/753 , C07C49/755 , C07C49/83 , C07C49/84 , C07C69/757 , C07C69/94 , C07C205/37 , C07C205/45 , C07C215/64 , C07C217/94 , C07C235/34 , C07C235/66 , C07C247/10 , C07C255/36 , C07C255/53 , C07C2603/16 , C07C2603/26 , C07D295/096 , C07D295/185 , C07D307/92 , C07D311/78 , C07C49/603
摘要: The present invention relates to novel tetralin ER-β agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon cancer, prostate cancer, infertility, depression, leukemia, inflammatory bowel disease, and arthritis.
摘要翻译: 本发明涉及新的四氢萘酮ER-&bgr; 激动剂化合物,其药物组合物,以及这些化合物用于治疗ER- 介导性疾病如夜尿症,阻塞性尿失禁,良性前列腺肥大,肥胖症,痴呆,高血压,失禁,结肠癌,前列腺癌,不育症,抑郁症,白血病,炎性肠病和关节炎。
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