公开(公告)号：US20130289402A1

公开(公告)日：2013-10-31

申请号：US13992083

申请日：2011-12-01

申请人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

IPC分类号： A61B8/08

CPC分类号： A61B8/08 ,  A61B8/0825 ,  A61B8/0891 ,  A61B8/485 ,  G01S7/52049 ,  G01S7/52071 ,  G01S7/52073

摘要： When multiple tissues having differing speeds of sound are intermixed in the viewing field of a measured subject such as a living body, the invention measures hardness, such as modulus of elasticity or viscosity, with high precision. As a means for detecting heterogeneity of sound speed in the tissues of a subject, a displacement-generating transmission beam is applied from a displacement generating beam-generating device (13) of a displacement-generating unit (10) on an ultrasound probe (1) to irradiate a focused ultrasonic wave into the living tissue and generate a shear wave. From the displacement-time waveforms of multiple positions of the shear wave detected using the displacement detection transmission beam-generating device (22) and the displacement detection received beam-computing device (23) of a displacement-detecting unit (20), at least two pieces of information, such as the integrated value and the maximum amplitude value, are obtained. On the basis of the two pieces of information, a heterogeneity-detecting device (26) of the displacement-detecting unit (20) detects the physical magnitude associated with the heterogeneity in sound speed arising from the tissue structure and displays same on a display (5).

摘要翻译： 当具有不同声速的多个组织混合在诸如生物体的被测量对象的视野中时，本发明以高精度测量诸如弹性模量或粘度的硬度。 作为用于检测被检体的组织中的声速的异质性的手段，从位移产生单元（10）的位移产生光束产生装置（13）向超声波探头（1）施加位移产生透射束 ）将聚焦超声波照射到活体组织中并产生剪切波。 根据位移检测传输光束产生装置（22）检测到的剪切波的多个位置和位移检测单元（20）的位移检测接收光束计算装置（23）的位移时间波形，至少 获得两个信息，例如积分值和最大振幅值。 基于两条信息，位移检测单元（20）的异质性检测装置（26）检测与由组织结构产生的声速异质性相关的物理量值，并将其显示在显示器上 5）。

公开(公告)号：US09439620B2

公开(公告)日：2016-09-13

申请号：US13992083

申请日：2011-12-01

申请人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S7/52

CPC分类号： A61B8/08 ,  A61B8/0825 ,  A61B8/0891 ,  A61B8/485 ,  G01S7/52049 ,  G01S7/52071 ,  G01S7/52073

摘要： When multiple tissues having differing speeds of sound are intermixed in the viewing field of a measured subject such as a living body, the invention measures hardness, such as modulus of elasticity or viscosity, with high precision.

摘要翻译： 当具有不同声速的多个组织混合在诸如生物体的被测量对象的视野中时，本发明以高精度测量诸如弹性模量或粘度的硬度。

公开(公告)号：US20130317361A1

公开(公告)日：2013-11-28

申请号：US13982801

申请日：2011-12-28

申请人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

IPC分类号： A61B8/08

CPC分类号： A61B8/485 ,  A61B8/42 ,  A61B8/469 ,  A61B8/5246 ,  G01S7/52042

摘要： An ultrasound diagnostic apparatus with which elastic modulus can be measured when measuring elastic modulus using shear wave generation. The ultrasound diagnostic apparatus includes an ultrasound probe that sends and receives echo signals, a strain-computing unit that receives an echo signal from the body by radiating a first displacement-detecting beam and computes strain information in a Region 1, a measurement position-selecting unit that selects a Region 2, within Region 1, based on the strain information, a displacement-generating unit that radiates a focused beam into the body and displaces the tissue, an elastic modulus-computing unit that receives an echo signal from the body by radiating a second displacement-detecting beam, detects the shear wave displacement that results from the focused beam, and computes the elastic modulus in Region 2, and a display unit that displays the strain image that is based on the strain information in Region 1 and the elastic modulus.

摘要翻译： 一种使用剪切波产生测量弹性模量时可以测量弹性模量的超声波诊断装置。 超声波诊断装置包括发送和接收回波信号的超声波探头，应变计算单元，其通过辐射第一位移检测光束从身体接收回波信号，并计算区域1中的应变信息，测量位置选择 基于应变信息在区域1内选择区域2的单元，将聚焦光束照射到体内并使组织发生位移的位移产生单元，弹性模量计算单元，其从身体接收回波信号， 辐射第二位移检测光束，检测由聚焦光束产生的剪切波位移，并计算区域2中的弹性模量;以及显示单元，其显示基于区域1中的应变信息的应变图像，以及 弹性模量。

公开(公告)号：US20120136250A1

公开(公告)日：2012-05-31

申请号：US13386184

申请日：2010-08-04

申请人： Marie Tabaru ,  Takashi Azuma ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Kunio Hashiba

IPC分类号： A61B8/00

CPC分类号： A61B8/08 ,  A61B8/14 ,  A61B8/4488 ,  A61B8/485 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52042 ,  G01S15/8954

摘要： In a radiation-pressure elastography technique for transmitting a ultrasound focused beam into a test object body and diagnosing the hardness thereof, it is required to consider high sensitivity and safety.In the present invention, the focused beam is transmitted to two positions as a means for displacing a tissue and exciting a shear wave. In addition, time control is performed in such a manner that a transmit beam serves as a burst-chirp signal, and ultrasound waves are transmitted and received while sweeping a transmit frequency. On this occasion, when the distance between the two focused points and the transmit frequency become integral multiple of the wavelength, two waves interfere with each other, thereby obtaining a large amplitude. Furthermore, when the transmit frequency becomes equal to a resonance frequency peculiar to the tissue, the amplitude also becomes larger. Accordingly, a small intensity of transmit waveform enhances sensitivity. In addition, transmission using the burst-chirp signal facilitates widening of a bandwidth of the transmit frequency, enabling usage of a frequency highly sensitive for a target measurement site. Optional number of focused points and arbitrary positions thereof allow a wide area to be covered.

摘要翻译： 在用于将超声聚焦光束传输到测试对象体内并且诊断其硬度的放射压弹性成像技术中，需要考虑高灵敏度和安全性。 在本发明中，聚焦光束作为用于移动组织并激发剪切波的装置被传送到两个位置。 此外，以发射波束用作脉冲串啁啾信号的方式执行时间控制，并且在扫描发射频率的同时发射和接收超声波。 在这种情况下，当两个聚焦点和发射频率之间的距离成为波长的整数倍时，两个波彼此干涉，从而获得大的振幅。 此外，当发射频率等于组织特有的共振频率时，振幅也变大。 因此，小的发射波长强度提高了灵敏度。 此外，使用脉冲串啁啾信号的传输有助于扩大发射频率的带宽，使得能够使用对于目标测量站点高度敏感的频率。 可选数量的聚焦点和任意位置允许覆盖广泛的区域。

公开(公告)号：US08979759B2

公开(公告)日：2015-03-17

申请号：US13521776

申请日：2011-02-02

申请人： Tomohiko Tanaka ,  Takashi Azuma ,  Marie Tabaru ,  Kunio Hashiba

发明人： Tomohiko Tanaka ,  Takashi Azuma ,  Marie Tabaru ,  Kunio Hashiba

IPC分类号： A61B8/04 ,  A61B8/08 ,  A61B8/14

CPC分类号： A61B8/0883 ,  A61B8/04 ,  A61B8/485 ,  A61B8/486

摘要： Ultrasonic imaging device noninvasively measures cardiac muscle stiffness or intracardiac pressure. The device includes: an ultrasonic probe (2) transmitting and receiving ultrasonic waves to and from the heart; a signal-processing section (15) processing reflected echo signals; a display section (14) displaying results of signal processing as an image; and an input section (10) setting a predetermined point on the image. The signal-processing section (15) includes: a shape-extracting section (152) perceiving information on the shape of the heart from the reflected echo signals; a natural-frequency detecting section (153) detecting natural frequency of the heart from the reflected echo signals; and a calculating section (154) calculating stiffness of the cardiac muscle or the intracardiac pressure, wherein the calculating section (154) accurately calculates the stiffness of the cardiac muscle from the natural frequency of the heart and calculates the intracardiac pressure from the stiffness of the cardiac muscle that has been calculated.

摘要翻译： 超声成像装置无侵害性地测量心肌僵硬或心内压。 该装置包括：超声波探头（2），用于向心脏和/或从心脏传递和接收超声波; 处理反射回波信号的信号处理部（15） 显示部分（14），显示作为图像的信号处理的结果; 以及设置图像上的预定点的输入部（10）。 信号处理部（15）包括：形状提取部（152），从反射的回波信号中感知关于心脏的形状的信息; 自然频率检测部分，从反射回波信号中检测心脏的固有频率; 以及计算心肌的心率或心脏内压的计算部（154），其中，计算部（154）从心脏的固有频率精确地计算心肌的刚度，并从心脏的刚度算出心内压 已经计算出的心肌。

公开(公告)号：US08647276B2

公开(公告)日：2014-02-11

申请号：US13386184

申请日：2010-08-04

申请人： Marie Tabaru ,  Takashi Azuma ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Kunio Hashiba

IPC分类号： A61B8/00

CPC分类号： A61B8/08 ,  A61B8/14 ,  A61B8/4488 ,  A61B8/485 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52042 ,  G01S15/8954

摘要： In a radiation-pressure elastography technique for transmitting a ultrasound focused beam into a test object body and diagnosing the hardness thereof, it is required to consider high sensitivity and safety.In the present invention, the focused beam is transmitted to two positions as a means for displacing a tissue and exciting a shear wave. In addition, time control is performed in such a manner that a transmit beam serves as a burst-chirp signal, and ultrasound waves are transmitted and received while sweeping a transmit frequency. On this occasion, when the distance between the two focused points and the transmit frequency become integral multiple of the wavelength, two waves interfere with each other, thereby obtaining a large amplitude. Furthermore, when the transmit frequency becomes equal to a resonance frequency peculiar to the tissue, the amplitude also becomes larger. Accordingly, a small intensity of transmit waveform enhances sensitivity. In addition, transmission using the burst-chirp signal facilitates widening of a bandwidth of the transmit frequency, enabling usage of a frequency highly sensitive for a target measurement site. Optional number of focused points and arbitrary positions thereof allow a wide area to be covered.

摘要翻译： 在用于将超声聚焦光束传输到测试对象体内并且诊断其硬度的放射压弹性成像技术中，需要考虑高灵敏度和安全性。 在本发明中，聚焦光束作为用于移动组织并激发剪切波的装置传送到两个位置。 此外，以发射波束用作脉冲串啁啾信号的方式执行时间控制，并且在扫描发射频率的同时发射和接收超声波。 在这种情况下，当两个聚焦点和发射频率之间的距离成为波长的整数倍时，两个波彼此干涉，从而获得大的振幅。 此外，当发射频率等于组织特有的共振频率时，振幅也变大。 因此，小的发射波长强度提高了灵敏度。 此外，使用脉冲串啁啾信号的传输有助于扩大发射频率的带宽，使得能够使用对于目标测量站点高度敏感的频率。 可选数量的聚焦点和任意位置允许覆盖广泛的区域。

公开(公告)号：US20120296209A1

公开(公告)日：2012-11-22

申请号：US13521776

申请日：2011-02-02

申请人： Tomohiko Tanaka ,  Takashi Azuma ,  Marie Tabaru ,  Kunio Hashiba

发明人： Tomohiko Tanaka ,  Takashi Azuma ,  Marie Tabaru ,  Kunio Hashiba

IPC分类号： A61B8/04 ,  A61B8/08 ,  A61B8/14

CPC分类号： A61B8/0883 ,  A61B8/04 ,  A61B8/485 ,  A61B8/486

摘要： Provided is an ultrasonic imaging device that noninvasively measures the stiffness of the cardiac muscle, which is the heart muscle, or intracardiac pressure, which is the blood pressure inside the heart. The ultrasonic imaging device includes: an ultrasonic probe (2) that transmits and receives ultrasonic waves to and from the heart, which is the target organ inside the body; a signal-processing section (15) that processes reflected echo signals received by the ultrasonic probe; a display section (14) that displays the results of signal processing as an image; and an input section (10) for setting a predetermined point on the image displayed on the display section. The signal-processing section (15) includes: a shape-extracting section (152) that perceives information on the shape of the heart from the reflected echo signals; a natural-frequency detecting section (153) that detects the natural frequency of the heart from the reflected echo signals; and a calculating section (154) that calculates the stiffness of the cardiac muscle or the intracardiac pressure, wherein the calculating section (154) accurately calculates the stiffness of the cardiac muscle from the natural frequency of the heart and calculates the intracardiac pressure from the stiffness of the cardiac muscle that has been calculated.

摘要翻译： 提供了一种超声波成像装置，其非侵入性地测量作为心脏肌肉的心肌的刚度或作为心脏内的血压的心内压。 超声波成像装置包括：超声波探头（2），其将超声波与作为体内目标器官的心脏进行超声波的接收; 处理由超声波探头接收的反射回波信号的信号处理部分（15）; 显示部分（14），其将信号处理的结果显示为图像; 以及用于设置显示在显示部分上的图像上的预定点的输入部分（10）。 信号处理部（15）包括：形状提取部（152），从反射的回波信号中感知关于心脏的形状的信息; 自然频率检测部分，从反射回波信号中检测心脏的固有频率; 以及计算心脏的硬度或心内压力的计算部（154），其中计算部（154）从心脏的固有频率精确地计算心肌的刚度，并从刚度计算心内压 的心脏肌肉。

公开(公告)号：US09259205B2

公开(公告)日：2016-02-16

申请号：US13990063

申请日：2011-11-28

申请人： Tomohiko Tanaka ,  Takashi Azuma ,  Kunio Hashiba

发明人： Tomohiko Tanaka ,  Takashi Azuma ,  Kunio Hashiba

IPC分类号： A61B8/00 ,  A61B8/06 ,  A61B8/08

CPC分类号： A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/5246

摘要： Provided is a technology which quantitatively measures blood flow in the vicinity of circulatory organs. An ultrasound image capture device according to the present invention removes an image portion corresponding to an organ shape by taking the difference of a multi-frame ultrasound image, and thereafter computes a measured value of a blood flow velocity vector on the basis of a plurality of images at different timings (as per FIG. 3).

摘要翻译： 提供了一种定量测量循环器官附近血液流量的技术。 根据本发明的超声波图像捕获装置通过取多帧超声波图像的差异去除对应于器官形状的图像部分，然后基于多个超帧图像计算血流速度矢量的测量值 不同时间的图像（如图3所示）。

公开(公告)号：US20130289408A1

公开(公告)日：2013-10-31

申请号：US13990063

申请日：2011-11-28

申请人： Tomohiko Tanaka ,  Takashi Azuma ,  Kunio Hashiba

发明人： Tomohiko Tanaka ,  Takashi Azuma ,  Kunio Hashiba

IPC分类号： A61B8/06

CPC分类号： A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/5246

摘要： Provided is a technology which quantitatively measures blood flow in the vicinity of circulatory organs. An ultrasound image capture device according to the present invention removes an image portion corresponding to an organ shape by taking the difference of a multi-frame ultrasound image, and thereafter computes a measured value of a blood flow velocity vector on the basis of a plurality of images at different timings (as per FIG. 3).

摘要翻译： 提供了一种定量测量循环器官附近血液流量的技术。 根据本发明的超声波图像捕获装置通过取多帧超声波图像的差异去除对应于器官形状的图像部分，然后基于多个超帧图像计算血流速度矢量的测量值 不同时间的图像（如图3所示）。

公开(公告)号：US20130148894A1

公开(公告)日：2013-06-13

申请号：US13811964

申请日：2011-07-28

申请人： Mariko Yamamoto ,  Shin-ichiro Umemura ,  Takashi Azuma ,  Kunio Hashiba

发明人： Mariko Yamamoto ,  Shin-ichiro Umemura ,  Takashi Azuma ,  Kunio Hashiba

IPC分类号： G06K9/46

CPC分类号： G06K9/46 ,  G01S7/52036 ,  G01S15/8913 ,  G01S15/8922 ,  G01S15/8927 ,  G01S15/895 ,  G06T11/006

摘要： An objective is to enable calculation of a distribution of a physical property such as a density inside a measurement object, even when the distribution of the physical property value is non-uniform, within a feasible period of time without causing image deterioration due to phenomena such as refraction and multiple-reflections caused by the non-uniformity. To this end, the physical property value that makes an evaluation quantity be an extremum is outputted, where the evaluation quantity is a liner sum or a product of exponential function of: an equation residual quantity that is a residual being a difference between an operator term and an external force term of an equation of motion; a non-uniformity detection equation residual quantity that is a residual of an equation of detecting the non-uniformity of the physical property value from a matching degree of solutions of the equation of motion under two types of boundary conditions; and a conditional equation residual quantity that is a residual of a constraint condition.

摘要翻译： 目的是能够在可行的时间段内，即使在物理特性值的分布不均匀的情况下，能够计算测量对象内的物理性质（例如密度）的分布，而不会由于诸如此类的现象而导致图像劣化 作为由不均匀性引起的折射和多重反射。 为此，输出使评价量为极值的物理属性值，其中评价量为线性和或指数函数的乘积：作为残差的方程剩余量是运算符项之间的差 和运动方程的外力项; 根据两种类型的边界条件下的运动方程的匹配度，检测物理特性值的不均匀性的方程的残差的不均匀性检测方程残差量; 以及作为约束条件的残差的条件方程残差量。