公开(公告)号：US07196084B2

公开(公告)日：2007-03-27

申请号：US10343171

申请日：2001-07-26

申请人： Grégoire Prevost ,  Marie-Christine Brezak Pannetier ,  Marie-Odile Galcera Contour ,  Christophe Thurieau ,  Françoise Goubin Gramatica ,  Bernard Ducommun ,  Christophe Lanco

发明人： Grégoire Prevost ,  Marie-Christine Brezak Pannetier ,  Marie-Odile Galcera Contour ,  Christophe Thurieau ,  Françoise Goubin Gramatica ,  Bernard Ducommun ,  Christophe Lanco

IPC分类号： A01N43/58 ,  A61K31/50 ,  C07D237/02 ,  C07D295/00

CPC分类号： C07D295/26 ,  A61K31/137 ,  A61K31/165 ,  A61K31/18 ,  A61K31/381 ,  A61K31/445 ,  A61K31/495 ,  A61K31/63 ,  C07C217/84 ,  C07C229/36 ,  C07C235/66 ,  C07C311/08 ,  C07C311/13 ,  C07C311/21 ,  C07C311/29 ,  C07C311/37 ,  C07D233/84 ,  C07D295/135 ,  C07D295/192 ,  C07D333/22 ,  C07D333/34 ,  C07F9/12

摘要： The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical or R1 and R2 form together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CR3R4—, —O—, —S and NR5-radicals, R3 and R4 representing independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and R5 representing independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected independently among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical; B represents a —(CH2)i—(CO)— or —NH—CO—(CH2)n or —(CH2)p and i and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents a hydrogen atom or an alkyl radical; X represents a —(CH2)q— or (CH2)j—CO—(CH2)r—, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl, aminophenyl, alkylaminophenyl or dialkylaminophenyl radical or the radical (T)

公开(公告)号：US20060235027A1

公开(公告)日：2006-10-19

申请号：US11410659

申请日：2006-04-25

申请人： Gregoire Prevost ,  Marie-Christine Brezak Pannetier ,  Marie-Odile Galcera Contour ,  Christophe Thurieau ,  Francoise Goubin Gramatica ,  Bernard Ducommun ,  Christophe Lanco

发明人： Gregoire Prevost ,  Marie-Christine Brezak Pannetier ,  Marie-Odile Galcera Contour ,  Christophe Thurieau ,  Francoise Goubin Gramatica ,  Bernard Ducommun ,  Christophe Lanco

IPC分类号： A61K31/495 ,  A61K31/445 ,  A61K31/165

CPC分类号： C07D295/26 ,  A61K31/137 ,  A61K31/165 ,  A61K31/18 ,  A61K31/381 ,  A61K31/445 ,  A61K31/495 ,  A61K31/63 ,  C07C217/84 ,  C07C229/36 ,  C07C235/66 ,  C07C311/08 ,  C07C311/13 ,  C07C311/21 ,  C07C311/29 ,  C07C311/37 ,  C07D233/84 ,  C07D295/135 ,  C07D295/192 ,  C07D333/22 ,  C07D333/34 ,  C07F9/12

摘要： A method of inhibiting cdc25 phosphatases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount of a compound of the formula wherein the substituents are defined as in the specification.

摘要翻译： 一种抑制温血动物中的cdc25磷酸酶的方法，其包括向有需要的温血动物施用有效量的下式的化合物，其中取代基如说明书中所定义。

公开(公告)号：US20060154933A1

公开(公告)日：2006-07-13

申请号：US11350692

申请日：2006-02-09

申请人： Gregoire Prevost ,  Marie-Christine Brezak Pannetier ,  Marie-Odile Galcera Contour ,  Christophe Thurieau ,  Francoise Gramatica ,  Bernard Ducommun ,  Christophe Lanco

发明人： Gregoire Prevost ,  Marie-Christine Brezak Pannetier ,  Marie-Odile Galcera Contour ,  Christophe Thurieau ,  Francoise Gramatica ,  Bernard Ducommun ,  Christophe Lanco

IPC分类号： A61K31/496

CPC分类号： C07D295/26 ,  A61K31/137 ,  A61K31/165 ,  A61K31/18 ,  A61K31/381 ,  A61K31/445 ,  A61K31/495 ,  A61K31/63 ,  C07C217/84 ,  C07C229/36 ,  C07C235/66 ,  C07C311/08 ,  C07C311/13 ,  C07C311/21 ,  C07C311/29 ,  C07C311/37 ,  C07D233/84 ,  C07D295/135 ,  C07D295/192 ,  C07D333/22 ,  C07D333/34 ,  C07F9/12

摘要： A method of inhibiting cdc25 phosphatases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount of a compound of the formula wherein the substituents are defined as in the specification.

摘要翻译： 一种抑制温血动物中的cdc25磷酸酶的方法，其包括向有需要的温血动物施用有效量的下式的化合物，其中取代基如说明书中所定义。

公开(公告)号：US20080219987A1

公开(公告)日：2008-09-11

申请号：US11660703

申请日：2005-08-23

申请人： Bernard Ducommun ,  Martine Cazales ,  Bernard Monsarrat

发明人： Bernard Ducommun ,  Martine Cazales ,  Bernard Monsarrat

IPC分类号： A61K39/395 ,  C07K4/12 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18 ,  C12P21/04 ,  A61K38/03 ,  A61K38/08 ,  A61K38/10 ,  G01N33/00

CPC分类号： C12N9/16

摘要： A peptide sequence includes a fragment of at least 10 amino acids derived from the following SEQ ID NO:1: DRKMEVEELSpPLALGRFSL SEQ ID NO:1 wherein the serine residue in position 10 is phosphorylated, the above-mentioned fragment containing the phosphorylated serine residue. A polyclonal or monoclonal antibody capable of identifying a peptide sequence as defined above is also disclosed.

摘要翻译： 肽序列包括衍生自以下SEQ ID NO：1：DRKMEVEELSPLALGRFSL SEQ ID NO：1的至少10个氨基酸的片段，其中10位的丝氨酸残基被磷酸化， 所述片段含有磷酸化的丝氨酸残基。 还公开了能够鉴定上述肽序列的多克隆或单克隆抗体。

公开(公告)号：US20080008712A1

公开(公告)日：2008-01-10

申请号：US10560237

申请日：2004-06-08

申请人： Bernard Ducommun ,  Bernard Monsarrat ,  Claude Prigent

发明人： Bernard Ducommun ,  Bernard Monsarrat ,  Claude Prigent

IPC分类号： A61K39/395 ,  A61K38/10 ,  A61P35/00 ,  C07K16/44 ,  C12P21/08 ,  G01N33/566 ,  C07K7/08 ,  C07K14/00 ,  A61K38/16

CPC分类号： C12N9/16 ,  A61K38/00

摘要： The present invention relates to a peptide sequence characterized in that it comprises or is constituted by a fragment of at least approximately 10 amino acids originating from the following sequence SEQ ID NO: 1: TPVQNKRRRSpVTPPEEQQESEQ ID NO: 1 in which the serine residue in position 10 is phosphorylated, said above-mentioned fragment containing said phosphorylated serine residue. The present invention also relates to a polyclonal or monoclonal antibody capable of recognizing a peptide sequence as defined above.

摘要翻译： 本发明涉及一种肽序列，其特征在于其包含或由至少约10个氨基酸的片段构成，源自以下序列SEQ ID NO：1：

TPVQNKRRRS < / SUB> VTPPEEQQE SEQ ID NO：1 位置10被磷酸化，所述上述含有所述磷酸化丝氨酸残基的片段。 本发明还涉及能够识别上述肽序列的多克隆或单克隆抗体。

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