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公开(公告)号：US20090275624A1
公开(公告)日：2009-11-05
申请号：US11722075
申请日：2005-12-16
IPC分类号： A61K31/428 , C07D417/12 , C07D413/12 , A61K31/423 , A61P35/00 , A61P25/00 , A61P37/00
CPC分类号： C07D417/14 , C07D263/56 , C07D277/64
摘要： A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
摘要翻译： 本发明的主题是包含抑制cdc25磷酸酶特别是cdc25-C磷酸酶的2或3个苯并噻唑-4,7-二酮 - 或苯并恶唑-4,7-二酮型单元的新型化合物。 这些化合物特别可用于治疗癌症。
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公开(公告)号：US08017637B2
公开(公告)日：2011-09-13
申请号：US11722075
申请日：2005-12-16
IPC分类号： A61K31/428 , A61K31/423 , C07D417/12 , C07D413/12 , C07D417/14
CPC分类号： C07D417/14 , C07D263/56 , C07D277/64
摘要： A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
摘要翻译： 本发明的主题是包含抑制cdc25磷酸酶特别是cdc25-C磷酸酶的2或3个苯并噻唑-4,7-二酮 - 或苯并恶唑-4,7-二酮型单元的新型化合物。 这些化合物特别可用于治疗癌症。
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3.发明申请4,7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation And Their Therapeutic Uses 审中-公开4,7-二氧代苯并噻唑-2-甲酰胺衍生物及其制备及其治疗用途公开(公告)号：US20100317658A1
公开(公告)日：2010-12-16
申请号：US12849573
申请日：2010-08-03
IPC分类号： A61K31/428 , A61K31/5377 , A61K31/496 , A61K31/4725 , A61P35/00
CPC分类号： C07D277/68 , C07D417/12
摘要： A subject of the present invention is 4,7-dioxobenzothiazole-2-carboxamide derivatives, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
摘要翻译： 本发明的主题是抑制cdc25磷酸酶，特别是cdc25-C磷酸酶的4,7-二氧代苯并噻唑-2-甲酰胺衍生物。 这些化合物特别可用于治疗癌症。
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4.发明授权4,7-dioxobenzothiazole-2-carboxamide derivatives, their preparation and their therapeutic uses 失效4,7-二氧代苯并噻唑-2-甲酰胺衍生物，其制备及其治疗用途公开(公告)号：US07795284B2
公开(公告)日：2010-09-14
申请号：US11718791
申请日：2005-11-07
IPC分类号： A61K31/428 , A61K31/496 , C07D277/60 , C07D417/02
CPC分类号： C07D277/68 , C07D417/12
摘要： A subject of the present invention is 4,7-dioxobenzothiazole-2-carboxamide derivatives, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
摘要翻译： 本发明的主题是抑制cdc25磷酸酶，特别是cdc25-C磷酸酶的4,7-二氧代苯并噻唑-2-甲酰胺衍生物。 这些化合物特别可用于治疗癌症。
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公开(公告)号：US07196084B2
公开(公告)日：2007-03-27
申请号：US10343171
申请日：2001-07-26
申请人： Grégoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Françoise Goubin Gramatica , Bernard Ducommun , Christophe Lanco
发明人： Grégoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Françoise Goubin Gramatica , Bernard Ducommun , Christophe Lanco
IPC分类号： A01N43/58 , A61K31/50 , C07D237/02 , C07D295/00
CPC分类号： C07D295/26 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/381 , A61K31/445 , A61K31/495 , A61K31/63 , C07C217/84 , C07C229/36 , C07C235/66 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/37 , C07D233/84 , C07D295/135 , C07D295/192 , C07D333/22 , C07D333/34 , C07F9/12
摘要： The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical or R1 and R2 form together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CR3R4—, —O—, —S and NR5-radicals, R3 and R4 representing independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and R5 representing independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected independently among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical; B represents a —(CH2)i—(CO)— or —NH—CO—(CH2)n or —(CH2)p and i and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents a hydrogen atom or an alkyl radical; X represents a —(CH2)q— or (CH2)j—CO—(CH2)r—, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl, aminophenyl, alkylaminophenyl or dialkylaminophenyl radical or the radical (T)
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6.发明授权Benzothiazole-and benzoxazole-4, 7-dione derivatives and their use as dcd25 phosphatase inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮衍生物及其作为dcd25磷酸酶抑制剂的用途公开(公告)号：US07279467B2
公开(公告)日：2007-10-09
申请号：US10500411
申请日：2002-12-24
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物
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7.发明授权Benzothiazole- and benzooxazole-4,7-dione, derivatives and their use as cdc25 phosphate inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮，它们作为cdc25磷酸盐抑制剂的用途公开(公告)号：US07495021B2
公开(公告)日：2009-02-24
申请号：US11849092
申请日：2007-08-31
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428 , C07D277/64 , C07D277/66
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
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8.发明授权公开(公告)号：US08624037B2
公开(公告)日：2014-01-07
申请号：US13264972
申请日：2010-04-16
申请人： Dennis Bigg , Serge Auvin , Christophe Lanco , Grégoire Prevost
发明人： Dennis Bigg , Serge Auvin , Christophe Lanco , Grégoire Prevost
IPC分类号： A61K31/4166 , C07D403/06 , C07D403/12
CPC分类号： C07D403/12 , C07D403/06
摘要： The subject matter of the present application is novel imidazolidine-2,4-dione derivatives. These products have an antiproliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.
摘要翻译： 本申请的主题是新的咪唑烷-2,4-二酮衍生物。 这些产品具有抗增殖活性。 它们特别有利于治疗与异常细胞增殖相关的病理状况和疾病，例如癌症。 本发明还涉及含有所述产品的药物组合物及其用于制备药物的用途。
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公开(公告)号：US20090186930A1
公开(公告)日：2009-07-23
申请号：US12298757
申请日：2007-04-26
IPC分类号： A61K31/4164 , C07D233/58 , A61P35/00
CPC分类号： C07D233/64
摘要： The invention concerns novel imidazole derivatives of general formula (I), wherein Z′ and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
摘要翻译： 本发明涉及通式（I）的新型咪唑衍生物，其中Z'和Z代表不同的可变基团。 所述产品具有抗肿瘤活性。 本发明还涉及含有所述产品的药物组合物及其用于制备抗肿瘤药物的用途。
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公开(公告)号：US08188133B2
公开(公告)日：2012-05-29
申请号：US12298757
申请日：2007-04-26
IPC分类号： A61K31/33 , C07D233/58
CPC分类号： C07D233/64
摘要： The invention concerns novel imidazole derivatives of general formula (I), wherein Z′ and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
摘要翻译： 本发明涉及通式（I）的新型咪唑衍生物，其中Z'和Z代表不同的可变基团。 所述产品具有抗肿瘤活性。 本发明还涉及含有所述产品的药物组合物及其用于制备抗肿瘤药物的用途。
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