-
公开(公告)号：US09236234B2
公开(公告)日：2016-01-12
申请号：US14214558
申请日：2014-03-14
Applicant: Ching Wu , Mark A Osgood
Inventor： Ching Wu , Mark A Osgood
CPC classification number: H01J49/061 , C07B63/00 , G01N27/622 , H01J49/0027
Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.
Abstract translation: 本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。 通过AC离子浇口的离子可以在光谱仪器中进一步分离。 使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。 对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。 此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离 然后基于它们的低场离子迁移率进一步分离。
-
公开(公告)号：US08884221B2
公开(公告)日：2014-11-11
申请号：US13475993
申请日：2012-05-20
Applicant: Ching Wu , Clinton Alawn Krueger , Anthony Joseph Midey , Mark A Osgood
Inventor： Ching Wu , Clinton Alawn Krueger , Anthony Joseph Midey , Mark A Osgood
CPC classification number: G01N27/622
Abstract: An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
Abstract translation: 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。
-
公开(公告)号：US11417507B2
公开(公告)日：2022-08-16
申请号：US17107481
申请日：2020-11-30
Applicant: Mark A Osgood , Ching Wu
Inventor： Mark A Osgood , Ching Wu
IPC: H01J49/00 , G01N27/622 , H01J49/06 , C07B63/00 , H01J49/04
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.
-
公开(公告)号：US10276358B2
公开(公告)日：2019-04-30
申请号：US15665421
申请日：2017-07-31
Applicant: Ching Wu , Mark A Osgood
Inventor： Ching Wu , Mark A Osgood
Abstract: An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.
-
公开(公告)号：US10049865B2
公开(公告)日：2018-08-14
申请号：US14703868
申请日：2015-05-04
Applicant: Mark A Osgood , Ching Wu
Inventor： Mark A Osgood , Ching Wu
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
-
Patent Agency Ranking
公开(公告)号：US09859105B2
公开(公告)日：2018-01-02
申请号：US14742653
申请日：2015-06-17
Applicant: Adam Michael Graichen , Robert H Jackson , Mark A Osgood , Ching Wu , Jianglin Wu
Inventor： Adam Michael Graichen , Robert H Jackson , Mark A Osgood , Ching Wu , Jianglin Wu
CPC classification number: H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
Abstract: A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
-
公开(公告)号：US09719963B2
公开(公告)日：2017-08-01
申请号：US14537863
申请日：2014-11-10
Applicant: Ching Wu , Clinton Alawn Krueger , Anthony Joseph Midey , Mark A Osgood
Inventor： Ching Wu , Clinton Alawn Krueger , Anthony Joseph Midey , Mark A Osgood
IPC: G01N27/62
CPC classification number: G01N27/622
Abstract: An ion mobility spectrometry method wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. Ion mobility spectrometer operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
-
公开(公告)号：US20210111012A1
公开(公告)日：2021-04-15
申请号：US17107481
申请日：2020-11-30
Applicant: Mark A Osgood , Ching Wu
Inventor： Mark A Osgood , Ching Wu
IPC: H01J49/00 , G01N27/622 , H01J49/06 , C07B63/00 , H01J49/04
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.
-
公开(公告)号：US10854437B2
公开(公告)日：2020-12-01
申请号：US16102227
申请日：2018-08-13
Applicant: Mark A Osgood , Ching Wu
Inventor： Mark A Osgood , Ching Wu
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
-
公开(公告)号：US20190006160A1
公开(公告)日：2019-01-03
申请号：US16102227
申请日：2018-08-13
Applicant: Mark A Osgood , Ching Wu
Inventor： Mark A Osgood , Ching Wu
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.016 seconds)
