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公开(公告)号：US20110174625A1
公开(公告)日：2011-07-21
申请号：US12450633
申请日：2008-04-04
申请人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Daniel Branton , William B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
发明人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Daniel Branton , William B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
IPC分类号： G01N27/447
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译： 本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在纳米孔中被另一种化合物（例如酶）作用的装置和方法。 所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。 本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。
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公开(公告)号：US20110005918A1
公开(公告)日：2011-01-13
申请号：US12080684
申请日：2008-04-04
申请人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Wiliam B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
发明人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Wiliam B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译： 本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在纳米孔中被另一种化合物（例如酶）作用的装置和方法。 所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。 本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。
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公开(公告)号：US20100035260A1
公开(公告)日：2010-02-11
申请号：US12459059
申请日：2009-06-26
申请人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
发明人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译： 本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在不需要终止核苷酸的情况下在纳米孔中被另一种化合物（例如酶）作用的装置和方法。 所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。 本发明特别用于药物发现，分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。
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公开(公告)号：US08679747B2
公开(公告)日：2014-03-25
申请号：US12459059
申请日：2009-06-26
申请人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
发明人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译： 本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在不需要终止核苷酸的情况下在纳米孔中被另一种化合物（例如酶）作用的装置和方法。 所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。 本发明特别用于药物发现，分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。
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