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公开(公告)号：US07265096B2
公开(公告)日：2007-09-04
申请号：US10701965
申请日：2003-11-04
申请人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
发明人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
CPC分类号： C07H19/06
摘要： The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infections.
摘要翻译： 本发明提供吉西他滨前药，制备吉西他滨前药的方法，吉西他滨前药的药物组合物和使用吉西他滨前药的方法及其药物组合物治疗或预防疾病或病症如癌症或病毒感染。
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公开(公告)号：US20100016254A1
公开(公告)日：2010-01-21
申请号：US12556458
申请日：2009-09-09
申请人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
发明人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
IPC分类号： A61K31/7068 , C07H19/06 , A61P35/00
CPC分类号： C07H19/06
摘要： The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.
摘要翻译： 本发明提供吉西他滨前药，制备吉西他滨前药的方法，吉西他滨前药的药物组合物和使用吉西他滨前药的方法和使用吉西他滨前药治疗或预防疾病或病症如癌症或病毒感染的药物组合物。
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公开(公告)号：US07608602B2
公开(公告)日：2009-10-27
申请号：US11844922
申请日：2007-08-24
申请人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
发明人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
CPC分类号： C07H19/06
摘要： The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.
摘要翻译： 本发明提供吉西他滨前药，制备吉西他滨前药的方法，吉西他滨前药的药物组合物和使用吉西他滨前药的方法和使用吉西他滨前药治疗或预防疾病或病症如癌症或病毒感染的药物组合物。
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公开(公告)号：US07803785B2
公开(公告)日：2010-09-28
申请号：US12556458
申请日：2009-09-09
申请人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
发明人： Mark A. Gallop , Ge Peng , Thomas F. Woiwode , Kenneth C. Cundy
CPC分类号： C07H19/06
摘要： The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.
摘要翻译： 本发明提供吉西他滨前药，制备吉西他滨前药的方法，吉西他滨前药的药物组合物和使用吉西他滨前药的方法以及使用吉西他滨前药治疗或预防疾病或病症如癌症或病毒感染的药物组合物。
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公开(公告)号：US08163958B2
公开(公告)日：2012-04-24
申请号：US13095101
申请日：2011-04-27
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C233/00 , C07C69/00
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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公开(公告)号：US07601708B2
公开(公告)日：2009-10-13
申请号：US11183911
申请日：2005-07-19
申请人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
发明人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
CPC分类号： C07K5/0205 , A61K31/56 , A61K38/00 , A61K47/54 , A61K47/554 , A61K47/64 , A61K47/65 , C07C237/12 , C07C237/20 , C07C323/60 , C07C2601/14 , C07D207/16 , C07D233/64
摘要： This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions that are used in such methods.
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公开(公告)号：US20090137834A1
公开(公告)日：2009-05-28
申请号：US12364453
申请日：2009-02-02
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C227/14
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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公开(公告)号：US07413536B1
公开(公告)日：2008-08-19
申请号：US09661927
申请日：2000-09-14
IPC分类号： C40B30/04
CPC分类号： G01N33/5088 , A61K49/0004 , C07C271/22 , C07C2603/18 , C07D271/08 , C07D277/32 , C07D311/16 , C07K1/047 , C12N15/1034 , C12N15/1086 , C40B40/00 , G01N33/5008 , G01N33/533 , G01N33/566 , G01N33/92
摘要： A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
摘要翻译： 提供了用于测定测试化合物的文库作为载体蛋白质（包括载体型和受体型转运蛋白）的转运蛋白质的配体和/或底物的多种方法。 公开了体外和体内筛选方法。 还提供了筛选DNA文库以鉴定编码转运蛋白的成员的方法。 还提供了包括通过筛选方法鉴定的化合物的药物组合物。
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公开(公告)号：US07323585B2
公开(公告)日：2008-01-29
申请号：US11145280
申请日：2005-06-03
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy
IPC分类号： C07C229/00 , A01N37/00
CPC分类号： C07C229/36
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
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公开(公告)号：US07049305B2
公开(公告)日：2006-05-23
申请号：US11053324
申请日：2005-02-09
申请人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
发明人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
CPC分类号： C07D233/64 , A61K38/00 , A61K47/554 , A61K47/64 , A61K47/65 , C07C237/12 , C07C237/20 , C07C323/60 , C07C2601/14 , C07D207/16 , C07K5/0205 , C07K5/06 , C07K5/08
摘要： This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
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