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11 条记录 (耗时 0.018 秒)

    Apoptotic peptides
    1.
    发明授权
    Apoptotic peptides 失效
    凋亡肽

    公开(公告)号：US6127178A

    公开(公告)日：2000-10-03

    申请号：US45764

    申请日：1998-03-20

    申请人： Mark A. Israel ,  Monica Florio

    发明人： Mark A. Israel ,  Monica Florio

    IPC分类号： A61K38/17 ,  C07K14/47 ,  C12P21/04 ,  C12N5/10 ,  A01N43/04 ,  C12P21/06 ,  G01N33/00

    CPC分类号： C07K14/4747 ,  A61K38/1709 ,  G01N2500/10

    摘要： Apoptosis-promoting recombinant Id polypeptides comprise an Id N-terminus domainpeptides comprise an Id N-terminus domain peptide comprising an effective portion of the N-terminal domain of a natural Id protein. The polypeptides may be produced recombinantly from transformed host cells from the subject recombinant Id polypeptide encoding nucleic acids. The invention provides methods of making and using the subject compositions and mimic thereof to modulate cellular physiology, and especially promote apoptosis and in the biopharmaceutical industry.

    摘要翻译： 促凋亡重组Id多肽包含IdN末端结构域，其包含Id N末端结构域肽，其包含天然Id蛋白的N末端结构域的有效部分。 可以从编码核酸的受试者重组Id多肽的转化的宿主细胞重组产生多肽。 本发明提供了制备和使用本发明组合物并模拟其用于调节细胞生理学，特别是促进细胞凋亡和生物制药工业中的方法。

    Modal variable valve actuation system for internal combustion engine and method for operating the same
    2.
    发明授权
    Modal variable valve actuation system for internal combustion engine and method for operating the same 有权
    用于内燃机的模态可变气门驱动系统及其操作方法

    公开(公告)号：US06925976B2

    公开(公告)日：2005-08-09

    申请号：US10793663

    申请日：2004-03-05

    申请人： Mark A. Israel ,  John P. Harttey

    发明人： Mark A. Israel ,  John P. Harttey

    IPC分类号： F01L1/08 ,  F01L1/18 ,  F01L1/24 ,  F01L13/06 ,  F02D9/06 ,  F02D13/04 ,  F01L9/02

    CPC分类号： F01L1/08 ,  F01L1/181 ,  F01L1/2411 ,  F01L13/06 ,  F01L2001/0537 ,  F01L2105/00 ,  F02D9/06 ,  F02D13/04

    摘要： A variable valve actuation system for providing discrete exhaust and intake valve lift profiles for various operating modes of an internal combustion engine. The variable valve actuation system includes exhaust and intake rocker assemblies, exhaust and intake hydraulic extension devices operatively coupling corresponding rocker assemblies with respective engine valves and exhaust and intake control valves for selectively supplying the pressurized hydraulic fluid to the extension devices so as to independently switch them between a pressurized condition and a depressurized condition. The engine further includes an exhaust brake provided to initiate a small lift of the exhaust valve during the engine braking operation while the exhaust extension device maintains the exhaust valve open during a compression stroke for bleeder-compression release braking. The exhaust and intake valves can be adjusted independently to provide combinations of valve lift modes.

    摘要翻译： 一种可变气门致动系统，用于为内燃机的各种操作模式提供分立的排气和进气门升程曲线。 可变气门致动系统包括排气和进气摇杆组件，排气和进气液压延伸装置，可操作地将相应的摇臂组件与相应的发动机气门和排气和进气控制阀联接，用于选择性地将加压液压流体供应到延伸装置，以便独立地切换它们 在加压状态和减压条件之间。 发动机还包括排气制动器，用于在发动机制动操作期间启动排气门的小升程，同时排气延伸装置在排气压缩释放制动的压缩冲程期间保持排气门打开。 排气和进气阀可以独立调节，以提供气门升程模式的组合。

    Integrated lost motion system for retarding and EGR
    4.
    发明授权
    Integrated lost motion system for retarding and EGR 有权
    用于减速和EGR的综合失速系统

    公开(公告)号：US6152104A

    公开(公告)日：2000-11-28

    申请号：US196315

    申请日：1998-11-20

    申请人： Joseph M. Vorih ,  Mark A. Israel

    发明人： Joseph M. Vorih ,  Mark A. Israel

    IPC分类号： F01L13/00 ,  F01L9/02 ,  F01L13/06 ,  F02B47/08 ,  F02D13/02 ,  F02D13/04

    CPC分类号： F02B47/08 ,  F01L1/267 ,  F01L13/06 ,  F01L9/021 ,  F01L1/08 ,  F01L2001/34446 ,  F01L2105/00 ,  Y02T10/121

    摘要： A variably timed internal combustion engine valve actuation system and method for opening valves in internal combustion engines. The system functions during both positive power and engine braking, to control the amount of "lost motion" between a valve and a means for opening the valve. In particular, the invention relates to a lost motion engine valve actuation system using a dedicated cam for effecting exhaust valve openings for compression release braking and exhaust gas recirculation ("EGR").

    摘要翻译： 可变定时的内燃机气门致动系统及其在内燃机中打开阀门的方法。 该系统在正功率和发动机制动期间都起作用，以控制阀和用于打开阀的装置之间的“运动”的量。 特别地，本发明涉及使用专用凸轮来实现用于压缩释放制动和废气再循环（“EGR”）的排气阀开口的失速发动机气门致动系统。

    Engine valve actuator with valve seating control
    6.
    发明授权
    Engine valve actuator with valve seating control 失效

    公开(公告)号：US06412457B1

    公开(公告)日：2002-07-02

    申请号：US09143403

    申请日：1998-08-28

    申请人： Joseph M. Vorih ,  Kevin J. Kinerson ,  Mark A. Israel

    发明人： Joseph M. Vorih ,  Kevin J. Kinerson ,  Mark A. Israel

    IPC分类号： F01L116

    CPC分类号： F01L1/245 ,  F01L1/16 ,  F01L9/02 ,  F01L13/06

    摘要： The present invention provides a hydraulic actuator for operating an engine valve, which includes a means for controlling the seating velocity of the valve. The design allows for free, unrestricted movement of the actuator piston during opening of the engine valve, and an unrestricted return of the piston and valve until the valve is within a predetermined distance of the valve seat. Once within this predetermined range, the return velocity of the actuator piston and engine valve are limited by the rate at which a fluid may escape through a restriction. The restriction is calibrated to provide the desired maximum valve seating velocity. The invention also provides for automatic lash adjustment.

    Method for inhibiting tumor cell growth by administering to tumor cells expressing a nucleic acid encoding a connexin and a pro-drug
    7.
    发明授权
    Method for inhibiting tumor cell growth by administering to tumor cells expressing a nucleic acid encoding a connexin and a pro-drug 失效
    通过对表达编码连接蛋白和前体药物的核酸的肿瘤细胞施用来抑制肿瘤细胞生长的方法

    公开(公告)号：US6149904A

    公开(公告)日：2000-11-21

    申请号：US791291

    申请日：1997-01-30

    申请人： James R. Fick ,  Mark A. Israel

    发明人： James R. Fick ,  Mark A. Israel

    IPC分类号： A61K31/00 ,  A61K48/00 ,  C12N5/00 ,  C12N15/00

    CPC分类号： A61K31/00

    摘要： In its broadest terms, the invention provides methods for the enhanced intracellular delivery of therapeutically active molecules to a target tumor cell. In a preferred embodiment, the method comprises providing engineered cells that express a heterologous nucleic acid that encodes a connexin and that contain a pro-drug activating gene, and contacting target tumor cells in a solid tumor with engineered cells that form functional gap junctions with said target tumor cells, such that the therapeutic molecule passes through a gap junction to a target tumor cell. More particularly, the invention involves providing engineered non-tumorigenic cells that express a first heterologous nucleic acid that encodes a connexin and a second heterologous nucleic acid that encodes a pro-drug activating molecule that converts a nontoxic substrate to a toxic metabolite, then contacting tumor cells in a solid tumor with engineered cells that form functional gap junctions with said tumor cells, and then exposing the engineered and tumor cells to the nontoxic substrate, whereby the nontoxic substrate is converted to the toxic metabolite in cells that expresses the pro-drug activating molecule, and the toxic metabolite then passes through gap junctions to adjacent coupled tumor cells, thereby inhibiting the cell growth of the tumor cells that contain the toxic metabolite.

    摘要翻译： 在其最广泛的术语中，本发明提供了用于增强细胞内递送治疗活性分子到靶肿瘤细胞的方法。 在优选的实施方案中，所述方法包括提供表达编码连接蛋白并含有前药活化基因的异源核酸的工程细胞，并将实体肿瘤中的目标肿瘤细胞与与所述细胞形成功能性间隙连接的工程细胞接触 目标肿瘤细胞，使得治疗分子通过间隙连接到靶肿瘤细胞。 更具体地，本发明涉及提供工程化的非致瘤细胞，其表达编码连接蛋白的第一异源核酸和编码将无毒底物转化为有毒代谢物的前药激活分子的第二异源核酸，然后接触肿瘤 具有与所述肿瘤细胞形成功能性间隙连接的工程化细胞的实体肿瘤中的细胞，然后将工程化和肿瘤细胞暴露于无毒底物，由此将无毒底物转化为表达前药活化的细胞中的有毒代谢物 分子，然后有毒代谢物通过间隙连接到相邻的偶联肿瘤细胞，从而抑制含有毒性代谢物的肿瘤细胞的细胞生长。

    Apparatus and control for variable exhaust brake
    9.
    发明授权
    Apparatus and control for variable exhaust brake 失效
    可变排气制动器的设备和控制

    公开(公告)号：US06810850B2

    公开(公告)日：2004-11-02

    申请号：US10125566

    申请日：2002-04-19

    申请人： Derek Anderson ,  Mark A. Israel ,  Robert B. Price

    发明人： Derek Anderson ,  Mark A. Israel ,  Robert B. Price

    IPC分类号： F02D906

    CPC分类号： F02D9/06 ,  F02D9/10 ,  F02D41/1448 ,  G05D16/2093

    摘要： A controlled exhaust brake for an engine comprises an exhaust restrictor located in an exhaust system downstream of an exhaust manifold of an engine. An actuator operably associated with the restrictor adjusts the restrictor. A pressure sensor operably associated with the exhaust manifold senses pressure in the exhaust manifold. A controller determines a set pressure in the exhaust manifold correlated with speed of the engine. The controller is in communication with the pressure sensor and the actuator, and causes adjustment of the restrictor in order to achieve and maintain the set pressure in the exhaust manifold.

    摘要翻译： 用于发动机的受控排气制动器包括位于发动机的排气歧管下游的排气系统中的排气限制器。 可操作地与限制器相关联的致动器调节限制器。 与排气歧管可操作地相关联的压力传感器感测排气歧管中的压力。 控制器确定与发动机速度相关的排气歧管中的设定压力。 控制器与压力传感器和致动器连通，并且导致限制器的调节，以便实现和保持排气歧管中的设定压力。