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1.发明申请Ophthalmic Formulations, Methods Of Manufacture And Methods of Normalizing Meibomian Gland Secretions 审中-公开眼科配方，制造方法和睑板腺分泌物正常化的方法公开(公告)号：US20120093876A1
公开(公告)日：2012-04-19
申请号：US12903881
申请日：2010-10-13
CPC分类号： A61K31/65 , A61K9/0048 , A61K9/14 , A61K47/06
摘要： The present invention provides process for producing non-aqueous compositions for normalizing meibomian gland secretions. The present invention further provides compositions and methods for treating and/or preventing the signs and/or symptoms of dry eye disease.
摘要翻译： 本发明提供了制备用于使睑板腺分泌物正常化的非水性组合物的方法。 本发明还提供了用于治疗和/或预防干眼病症状和/或症状的组合物和方法。
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2.发明申请公开(公告)号：US20100311688A1
公开(公告)日：2010-12-09
申请号：US12794315
申请日：2010-06-04
IPC分类号： A61K31/717 , A61P27/04
CPC分类号： A61K9/0048 , A61K47/38
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye. Methods of manufacture are also provided.
摘要翻译： 本发明提供用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的组合物及其使用方法。 这些组合物提供在眼睛滴注中舒适的新型眼用制剂中。 还提供了制造方法。
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公开(公告)号：US20110257136A1
公开(公告)日：2011-10-20
申请号：US12888117
申请日：2010-09-22
申请人： Mark B. Abelson , Matthew J. Chapin , Paul Gomes , George Minno , Jackie Nice
发明人： Mark B. Abelson , Matthew J. Chapin , Paul Gomes , George Minno , Jackie Nice
CPC分类号： A61K31/56 , A61K9/0048 , A61K31/135 , A61K31/495
摘要： The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis rhinitis, and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
摘要翻译： 本发明提供了西替利嗪的稳定的局部制剂，其在滴注在眼睛中时提供舒适的制剂，并且有效治疗过敏性结膜炎和/或过敏性结膜炎。 本发明进一步提供了通过将本发明的西替利嗪制剂直接局部施用于眼睛来治疗需要这种治疗的受试者的过敏性结膜炎鼻炎和/或过敏性鼻结膜炎的方法。
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公开(公告)号：US20100240625A1
公开(公告)日：2010-09-23
申请号：US12724128
申请日：2010-03-15
申请人： Mark B. Abelson , Matthew J. Chapin , Paul Gomes , George Minno , Jackie Nice
发明人： Mark B. Abelson , Matthew J. Chapin , Paul Gomes , George Minno , Jackie Nice
IPC分类号： A61K31/56 , A61K31/4965 , A61P27/02 , A61P37/08
CPC分类号： A61K31/495 , A61K9/0048 , A61K9/08 , A61K31/4174 , A61K31/4965 , A61K31/56 , A61K31/569 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/186 , A61K47/26 , A61K47/38
摘要： The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
摘要翻译： 本发明提供了西替利嗪的稳定的局部制剂，其在滴注在眼睛中时提供舒适的制剂，并且有效治疗过敏性结膜炎和/或过敏性结膜炎。 本发明还提供了通过将本发明的西替利嗪制剂直接局部施用于眼睛来治疗需要这种治疗的受试者的过敏性结膜炎和/或过敏性鼻结膜炎的方法。
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公开(公告)号：US06465506B2
公开(公告)日：2002-10-15
申请号：US10080873
申请日：2002-02-22
IPC分类号： A61K31415
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/4178 , A61K31/4409 , Y10S514/912
摘要： The present invention provides methods for instilling an ophthalmic agent. One embodiment of a method according to the invention includes causing a patient to refrain from blinking for at least a specified period of time so as to effect the substantial break down of the patient's tear film covering the patient's eye and instilling an ophthalmic agent to the patient's eye.
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公开(公告)号：US20180252700A1
公开(公告)日：2018-09-06
申请号：US15726690
申请日：2017-10-06
申请人： Mark B. Abelson
发明人： Mark B. Abelson
CPC分类号： G01N33/5008 , A61K9/0048 , A61K31/05 , A61P27/02 , G01N2800/52
摘要： The present invention provides methods of identifying a subject as susceptible to treatment for an ocular disease or disorder. The present invention also provides methods of screening an agent for the treatment of an ocular disease or disorder. In certain embodiments, the ocular disease or disorder is dry eye disease.
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公开(公告)号：US08664215B2
公开(公告)日：2014-03-04
申请号：US11690954
申请日：2007-03-26
申请人： Avner Ingerman , Frans Janssens , Anton Megens , Mark B. Abelson
发明人： Avner Ingerman , Frans Janssens , Anton Megens , Mark B. Abelson
IPC分类号： A61K31/551
CPC分类号： A61K31/55 , A61K9/0048 , A61K9/08
摘要： Compositions, kits, and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof containing alcaftadine or a pharmaceutically acceptable salt thereof.
摘要翻译： 用于治疗或预防眼部过敏和炎症的组合物，试剂盒和方法及其含有alcaftadine或其药学上可接受的盐的症状。
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公开(公告)号：US20090010850A1
公开(公告)日：2009-01-08
申请号：US12154665
申请日：2008-05-23
IPC分类号： A61K49/00 , A61K31/407 , A61K31/165 , A61K31/195
CPC分类号： A61K9/0048 , A61K31/407 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye.
摘要翻译： 本发明提供用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的组合物及其使用方法。 这些组合物提供在眼睛滴注中舒适的新型眼用制剂中。
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9.发明申请Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions 审中-公开使用神经递质和神经肽治疗干眼病和相关病症公开(公告)号：US20080261890A1
公开(公告)日：2008-10-23
申请号：US12214686
申请日：2008-06-20
CPC分类号： A61K38/1709 , A61K9/0048 , A61K31/137 , A61K31/198 , A61K31/4172 , A61K38/22 , A61K38/33 , A61K45/06 , A61K2300/00
摘要： The invention further features novel methods and compositions for treating and preventing dry eye by administration of neurotransmitters and/or neuropeptides, optionally in formulation with various other agents, as well as kits for the use of such novel formulations and methods.
摘要翻译： 本发明还涉及用于通过施用神经递质和/或神经肽，任选地与各种其它试剂配制来治疗和预防干眼症的新型方法和组合物，以及用于使用这种新型制剂和方法的试剂盒。
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10.发明授权
公开(公告)号：US5431907A
公开(公告)日：1995-07-11
申请号：US285300
申请日：1994-08-03
IPC分类号： A61K31/00 , A61K31/275 , A61K31/44 , A61K31/35
CPC分类号： A61K31/275 , A61K31/00 , A61K31/44 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915 , Y10S514/929
摘要： Ischemic disorders of the retina and associated tissues of the posterior segment of the eye are treated by topical administration to the eye of an amount of a calcium channel blocking agent effective to increase blood flow to those tissues. Calcium channel blocking agents of Class I are especially useful, and among these a preferred agent is verapamil hydrochloride.
摘要翻译： 通过局部施用一定量的钙通道阻断剂来治疗视网膜和眼后段的相关组织的缺血性疾病，其有效增加对这些组织的血流量。 I类钙通道阻断剂特别有用，其中优选的药物是盐酸维拉帕米。
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