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    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
    8.
    发明申请
    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
    用于产生脂质含量降低的HDL颗粒衍生物的方法和装置

    公开(公告)号：US20050004004A1

    公开(公告)日：2005-01-06

    申请号：US10796691

    申请日：2004-03-08

    申请人： Marc Bellotti ,  H. Brewer ,  Hassibullah Akeefe ,  Adam Conner ,  Timothy Perlman

    发明人： Marc Bellotti ,  H. Brewer ,  Hassibullah Akeefe ,  Adam Conner ,  Timothy Perlman

    IPC分类号： A61K9/127 ,  A61K38/17

    CPC分类号： G01N33/92 ,  A61K9/1275 ,  A61K38/1709 ,  C07K14/775 ,  A61K2300/00

    摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

    摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本方法可用于治疗动脉粥样硬化性血管疾病，并可与其他疗法（如他汀类药物，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制）结合使用。

    System, method and container for holding and delivering a solution
    9.
    发明授权
    System, method and container for holding and delivering a solution 失效
    用于持有和交付解决方案的系统，方法和容器

    公开(公告)号：US5865793A

    公开(公告)日：1999-02-02

    申请号：US922795

    申请日：1997-09-02

    申请人： Ying-Cheng Lo ,  Marc Bellotti

    发明人： Ying-Cheng Lo ,  Marc Bellotti

    IPC分类号： A61J1/10 ,  A61J1/00 ,  A61J1/05 ,  A61M1/28 ,  A61M31/00

    CPC分类号： A61J1/10 ,  A61M1/28 ,  Y10S128/24

    摘要： A system and a method for administering a solution (12) from a container (10) to a patient (35) are provided. The container (10) is divided into a solution side (16) and a drain side (18) separated by a tear line (20). The solution side (16) and the drain side (18) are in fluid communication with one another and with a port (28) that connects to the patient (35). The container (10) is separable at the tear line (20) such that contents of a peritoneum cavity of the patient (35) may be drained into the drain side (18) of the container (10). Then, the solution (12) from the solution side (16) of the container (10) may be drained from the container (10) into the patient (35).

    摘要翻译： 提供了一种从容器（10）向患者（35）施用溶液（12）的系统和方法。 容器（10）被分割成由撕开线（20）分开的溶液侧（16）和排出侧（18）。 溶液侧（16）和排出侧（18）彼此流体连通并且与连接到患者（35）的端口（28）流体连通。 容器（10）在撕裂线（20）处可分离，使得患者（35）的腹膜腔的内容物可以排出到容器（10）的排出侧（18）中。 然后，将来自容器（10）的溶液侧（16）的溶液（12）从容器（10）排出到患者（35）中。