公开(公告)号：US09348975B2

公开(公告)日：2016-05-24

申请号：US12431458

申请日：2009-04-28

申请人： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

发明人： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

IPC分类号： G06F19/00 ,  A61M1/28

CPC分类号： G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  G06F19/00

摘要： Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

摘要翻译： 已经使用动力学模型计算了透析患者腹膜腔腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间长度不应相同，但应根据患者情况和需要而变化。 一些患者有可能在透析液中表达更多的超滤液，这些患者可以从更长的停留时间中受益，而潜在的潜力较小的患者不会受益于更长的停留时间。 对于每个腹膜透析治疗结果，观察到最佳或高峰时间，例如超滤液体积率，尿素清除率（Kt / V）和肌酐清除率，同时使烃吸收最小化。 这些值和输入参数可用于定制每个患者的腹膜透析停留时间，估计将为每位患者产生最佳治疗结果的峰值停留时间。

公开(公告)号：US08764981B2

公开(公告)日：2014-07-01

申请号：US13296522

申请日：2011-11-15

申请人： Yuanpang Samuel Ding ,  Ying-Cheng Lo

发明人： Yuanpang Samuel Ding ,  Ying-Cheng Lo

IPC分类号： B01D61/30 ,  A61M1/14 ,  A61M37/00 ,  A61M1/28 ,  A61M1/16

CPC分类号： B01D61/30 ,  A61M1/1696 ,  A61M1/284 ,  A61M1/287

摘要： Dialysis treatment devices and methods for removing urea from dialysis waste streams are provided. In a general embodiment, the present disclosure provides a dialysis treatment device including: 1) a first filter having a filtration membrane, 2) a urea removal unit having urease and in fluid communication with the first filter, and 3) a second filter having an ion rejection membrane and in fluid communication with the first filter and the urea removal unit.

摘要翻译： 提供了用于从透析废物流中除去尿素的透析治疗装置和方法。 在一般实施例中，本发明提供一种透析治疗装置，其包括：1）具有过滤膜的第一过滤器，2）具有脲酶并与第一过滤器流体连通的尿素去除单元，以及3）具有 离子排斥膜并与第一过滤器和尿素去除单元流体连通。

公开(公告)号：US20120055864A1

公开(公告)日：2012-03-08

申请号：US13296522

申请日：2011-11-15

申请人： Yuanpang Samuel Ding ,  Ying-Cheng Lo

发明人： Yuanpang Samuel Ding ,  Ying-Cheng Lo

IPC分类号： B01D61/24

CPC分类号： B01D61/30 ,  A61M1/1696 ,  A61M1/284 ,  A61M1/287

摘要： Dialysis treatment devices and methods for removing urea from dialysis waste streams are provided. In a general embodiment, the present disclosure provides a dialysis treatment device including: 1) a first filter having a filtration membrane, 2) a urea removal unit having urease and in fluid communication with the first filter, and 3) a second filter having an ion rejection membrane and in fluid communication with the first filter and the urea removal unit.

摘要翻译： 提供了用于从透析废物流中除去尿素的透析治疗装置和方法。 在一般实施例中，本发明提供一种透析治疗装置，其包括：1）具有过滤膜的第一过滤器，2）具有脲酶并与第一过滤器流体连通的尿素去除单元，以及3）具有 离子排斥膜并与第一过滤器和尿素去除单元流体连通。

公开(公告)号：US20120029324A1

公开(公告)日：2012-02-02

申请号：US13088064

申请日：2011-04-15

申请人： Alp Akonur ,  John Kenneth Leypoldt ,  Ying-Cheng Lo ,  Baris Ugur Agar

发明人： Alp Akonur ,  John Kenneth Leypoldt ,  Ying-Cheng Lo ,  Baris Ugur Agar

IPC分类号： A61B5/15

CPC分类号： A61M1/1603 ,  A61M1/16 ,  A61M1/1611 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/3609 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/20 ,  G06F19/3481

摘要： A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.

摘要翻译： 在血液透析期间预测患者血清磷浓度的方法包括测量血液透析治疗会话时间的患者的血清磷浓度，以及通过初始血液透析期间患者的透析前和透析后体重之间的差异计算的超滤率 治疗时间除以治疗会话的总治疗时间，并估计患者的磷的移动清除率和磷酸盐的透析前分布体积。 然后可以在任何血液透析治疗期间的任何时间预测患者的血清磷浓度，其中估计磷移动清除率和患者的磷的透析前分布体积。

公开(公告)号：US20110257891A1

公开(公告)日：2011-10-20

申请号：US13088044

申请日：2011-04-15

申请人： Alp Akonur ,  John Kenneth Leypoldt ,  Ying-Cheng Lo ,  Baris Ugar Agar

发明人： Alp Akonur ,  John Kenneth Leypoldt ,  Ying-Cheng Lo ,  Baris Ugar Agar

IPC分类号： G06F19/00

CPC分类号： A61M1/1603 ,  A61M1/16 ,  A61M1/1611 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/3609 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/20 ,  G06F19/3481

摘要： A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.

摘要翻译： 在血液透析期间预测患者血清磷浓度的方法包括测量血液透析治疗会话时间的患者的血清磷浓度，以及通过初始血液透析期间患者的透析前和透析后体重之间的差异计算的超滤率 治疗时间除以治疗会话的总治疗时间，并估计患者的磷的移动清除率和磷酸盐的透析前分布体积。 然后可以在任何血液透析治疗期间的任何时间预测患者的血清磷浓度，其中估计磷移动清除率和患者的磷的透析前分布体积。

公开(公告)号：US20110010101A1

公开(公告)日：2011-01-13

申请号：US12498847

申请日：2009-07-07

申请人： Ying-Cheng Lo ,  Alp Akonur ,  Sarah Stobo Prichard

发明人： Ying-Cheng Lo ,  Alp Akonur ,  Sarah Stobo Prichard

IPC分类号： G06F19/00

CPC分类号： A61M1/28 ,  A61M1/1619

摘要： A simplified peritoneal equilibration test (S-PET) is disclosed. Instead of a lengthy peritoneal equilibration test (PET), the simplified procedure requires no blood sample and may use data from as few as two or three samples to classify a peritoneal membrane of a user. Typically, a peritoneal membrane or peritoneum of a dialysis patient, or other person, is classed as a high transport membrane, high-average transport membrane, a low-average transport membrane or a low transporter membrane. The S-PET may be performed at home by a user without the need to submit a blood sample. Kits for analyzing the samples may be furnished for home use. The kits may use disposable strips, microfluidic analyzers or chemical reagents, or may alternatively include reusable analysis equipment, such as optical or conductivity analysis equipment.

摘要翻译： 公开了一种简化的腹膜平衡试验（S-PET）。 代替长时间的腹膜平衡试验（PET），简化的程序不需要血液样品，并且可以使用少至两个或三个样品的数据来分类用户的腹膜。 通常，透析患者或其他人的腹膜或腹膜被分类为高运输膜，高平均运输膜，低平均运输膜或低转运膜。 S-PET可以由用户在家进行，而不需要提交血样。 用于分析样品的试剂盒可供家庭使用。 试剂盒可以使用一次性条，微流控分析仪或化学试剂，或者可以替代地包括可重复使用的分析设备，例如光学或电导率分析设备。

公开(公告)号：US20100314314A1

公开(公告)日：2010-12-16

申请号：US12482869

申请日：2009-06-11

申请人： Yuanpang Samuel Ding ,  Ying-Cheng Lo

发明人： Yuanpang Samuel Ding ,  Ying-Cheng Lo

IPC分类号： B01D61/32 ,  B01D61/04 ,  B01D61/28

CPC分类号： B01D61/30 ,  A61M1/1696 ,  A61M1/284 ,  A61M1/287

摘要： Dialysis treatment devices and methods for removing urea from dialysis waste streams are provided. In a general embodiment, the present disclosure provides a dialysis treatment device including: 1) a first filter having a filtration membrane, 2) a urea removal unit having urease and in fluid communication with the first filter, and 3) a second filter having an ion rejection membrane and in fluid communication with the first filter and the urea removal unit.

摘要翻译： 提供了用于从透析废物流中除去尿素的透析治疗装置和方法。 在一般实施例中，本发明提供一种透析治疗装置，其包括：1）具有过滤膜的第一过滤器，2）具有脲酶并与第一过滤器流体连通的尿素去除单元，以及3）具有 离子排斥膜并与第一过滤器和尿素去除单元流体连通。

公开(公告)号：US20100217180A1

公开(公告)日：2010-08-26

申请号：US12389886

申请日：2009-02-20

申请人： Alp Akonur ,  Ying-Cheng Lo

发明人： Alp Akonur ,  Ying-Cheng Lo

IPC分类号： A61M1/28 ,  G06F17/10 ,  G06G7/57 ,  G06G7/60

CPC分类号： G16H50/50 ,  A61M1/28 ,  A61M1/282

摘要： A method of modeling a patient's peritoneal dialysis drain phase includes (i) modeling a first segment of a drain phase curve as having a constant flowrate; (ii) modeling a second segment of a drain phase curve as having a decaying exponential flowrate; and (iii) incorporating a switching component into the first and second components so that (a) at a first time the first segment is active and while the second segment is inactive and (b) at a second time the first segment is inactive and while the second segment is active.

摘要翻译： 建模患者腹膜透析排泄阶段的方法包括（i）将排水相曲线的第一段建模为具有恒定的流速; （ii）将排水相曲线的第二段建模为具有衰减指数流速; 以及（iii）将切换组件并入到所述第一和第二组件中，使得（a）在第一时间第一段处于活动状态，而第二段处于非活动状态，并且（b）在第二时间段，第一段无效，而 第二段是活跃的。

公开(公告)号：US20100217179A1

公开(公告)日：2010-08-26

申请号：US12390002

申请日：2009-02-20

申请人： Ying-Cheng Lo ,  Rohit Vishnoi

发明人： Ying-Cheng Lo ,  Rohit Vishnoi

IPC分类号： A61M1/28

CPC分类号： A61M1/28 ,  A61M1/285 ,  A61M1/288

摘要： A peritoneal dialysis method includes (i) connecting smaller and larger supply containers to a junction, the smaller and larger supply bags both full of dialysate; (ii) allowing the junction to be connected to a patient's transfer set; allowing the patient to drain through the junction; (iii) allowing the patient to fill from the smaller supply container; and (iv) allowing the patient to refill the smaller supply container from the larger supply container.

摘要翻译： 腹膜透析方法包括（i）将较小和较大的供应容器连接到交界处，较小和较大的充满透析液的供应袋; （ii）允许接头连接到患者的转移组件; 允许患者通过交界处排出; （iii）允许患者从较小的供应容器中填充; 和（iv）允许患者将更小的供应容器从较大的供应容器中重新填充。

公开(公告)号：US20100198138A1

公开(公告)日：2010-08-05

申请号：US12696889

申请日：2010-01-29

申请人： Paul R. Chapman ,  Brian J. Connell ,  Ying-Cheng Lo

发明人： Paul R. Chapman ,  Brian J. Connell ,  Ying-Cheng Lo

IPC分类号： A61M39/28 ,  A61M1/28

CPC分类号： A61M1/285 ,  A61M39/12 ,  A61M39/28 ,  A61M39/286

摘要： Transfer sets are disclosed in the present patent. The transfer set provides a connection between a source of peritoneal dialysis fluid and a patient for whom peritoneal dialysis has been prescribed. The transfer sets disclosed herein are smaller and provide a more compact and convenient device by which a dialysis patient controls the flow of dialysis fluid to and from the peritoneum of the patient. The devices are more compact and convenient because they include more convenient mechanisms for starting and stopping flow of the dialysis fluid. It is also easy to determine whether the mechanism is in a closed or open configuration by simply looking at the mechanism.

摘要翻译： 转让集合在本专利中公开。 转移组提供腹膜透析液源和已经规定了腹膜透析的患者之间的连接。 本文公开的转移组较小，并且提供更紧凑和方便的装置，通过该装置透析患者控制透过液流入和离开患者腹膜的流动。 这些装置更紧凑和便利，因为它们包括更方便的起始和停止透析液流动的机构。 通过简单地查看机制，也很容易确定机制是否处于关闭或打开配置。