公开(公告)号：US07534348B2

公开(公告)日：2009-05-19

申请号：US10661994

申请日：2003-09-12

申请人： Douglas W. Reitz ,  Scott Ariagno ,  Mihir Sheth ,  Atif Yardimci ,  Robert A. Clarke ,  David W. Pennington ,  Michael R. Prisco ,  Edwin Chim ,  Robin Pauley ,  Craig Sandford ,  Arch Sites

发明人： Douglas W. Reitz ,  Scott Ariagno ,  Mihir Sheth ,  Atif Yardimci ,  Robert A. Clarke ,  David W. Pennington ,  Michael R. Prisco ,  Edwin Chim ,  Robin Pauley ,  Craig Sandford ,  Arch Sites

IPC分类号： B01D29/00 ,  B01D37/00 ,  A61M5/165

CPC分类号： A61M1/3633 ,  A61M1/0222 ,  A61M1/3687 ,  A61M2205/75

摘要： Flow-through systems for processing biological fluid are disclosed. The flow-through systems include a removal device in the flow path for removing unwanted compounds and agents. The removal device includes a removal media contained within a housing made of two separate portions sealed together. The housing is maintained in a substantially vertical disposition, thereby ensuring substantially uniform and complete exposure of the fluid to the media.

摘要翻译： 公开了用于处理生物流体的流通系统。 流通系统包括在流动路径中用于去除不想要的化合物和试剂的去除装置。 移除装置包括一个包含在由两个分开的部分密封在一起的壳体内的移除介质。 壳体保持基本垂直的布置，从而确保流体基本均匀且完全地暴露于介质。

公开(公告)号：US20090054873A1

公开(公告)日：2009-02-26

申请号：US12256986

申请日：2008-10-23

申请人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

发明人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

IPC分类号： A61M25/00 ,  B23K26/00 ,  H05B1/00

CPC分类号： A61M39/146 ,  A61M1/28 ,  A61M2205/6081 ,  B23K26/0619 ,  B23K26/067 ,  B23K26/282 ,  B23K2101/06 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1632 ,  B29C65/1664 ,  B29C65/1674 ,  B29C65/1687 ,  B29C65/2046 ,  B29C65/2061 ,  B29C65/7802 ,  B29C65/7841 ,  B29C66/1142 ,  B29C66/1312 ,  B29C66/137 ,  B29C66/5221 ,  B29C66/636 ,  B29C66/71 ,  B29C66/712 ,  B29C66/723 ,  B29C66/73115 ,  B29C66/73921 ,  B29C66/81267 ,  B29C66/8226 ,  B29C66/82263 ,  B29C66/857 ,  B29C66/9121 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91218 ,  B29C66/91221 ,  B29C66/9131 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/9161 ,  B29C66/961 ,  B29K2009/06 ,  B29K2023/0608 ,  B29K2023/0616 ,  B29K2023/0633 ,  B29K2023/0641 ,  B29K2023/065 ,  B29K2023/083 ,  B29K2031/04 ,  B29L2023/007 ,  Y10S138/07 ,  Y10T156/12 ,  Y10T156/1313 ,  Y10T428/1352 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/1397 ,  B29K2023/12

摘要： A laser strikes and aseptically heats or sterilizes the end of two flexible tube ends for connection. Tube holders are pushed toward each other to bring the tube ends into contact. A weld detector checks the characteristics of the weld. A laser optics assembly may be used to chance the direction of the lacer and focus the laser at the tube ends. In addition, a crimping device is used to compress a single flexible tube for disconnection. The laser strikes the compressed area. The crimping device continues to pinch the area and forms a seal in the tube. The tube is separated into two tube segments, each segment has a sealed end.

摘要翻译： 激光打击并无菌加热或灭菌用于连接的两个柔性管端的末端。 管保持器彼此推动以使管端接触。 焊缝检测器检查焊缝的特性。 可以使用激光光学组件来机会夹紧器的方向，并将激光器聚焦在管端。 此外，压接装置用于压缩单个柔性管以断开连接。 激光撞击压缩区域。 压接装置继续挤压该区域并在管中形成密封。 管分成两个管段，每个段具有密封端。

公开(公告)号：US06604545B2

公开(公告)日：2003-08-12

申请号：US10265936

申请日：2002-10-07

申请人： Mark E. Williamson ,  Scott R. Ariagno ,  Alan W. Marttila ,  Arnold C. Bilstad ,  Paul M. DiPerna ,  Michael R. Prisco ,  David W. Pennington ,  Atif M. Yardimci ,  Sidney T. Smith ,  Mark C. Perry ,  Marc Bellotti

发明人： Mark E. Williamson ,  Scott R. Ariagno ,  Alan W. Marttila ,  Arnold C. Bilstad ,  Paul M. DiPerna ,  Michael R. Prisco ,  David W. Pennington ,  Atif M. Yardimci ,  Sidney T. Smith ,  Mark C. Perry ,  Marc Bellotti

IPC分类号： F16K1514

CPC分类号： A61J7/0053 ,  A47G21/185 ,  A61J1/10 ,  A61J1/1475 ,  A61J7/0046 ,  A61M39/227 ,  A61M39/24 ,  A61M2039/2406 ,  A61M2039/242 ,  A61M2039/244 ,  A61M2039/2486 ,  F16K15/14 ,  F16K15/147 ,  Y10S137/907 ,  Y10T137/7781 ,  Y10T137/7836 ,  Y10T137/7882 ,  Y10T137/789

摘要： A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.

公开(公告)号：US07459054B2

公开(公告)日：2008-12-02

申请号：US11099169

申请日：2005-04-05

申请人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

发明人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

IPC分类号： B29C65/00

CPC分类号： A61M39/146 ,  A61M1/28 ,  A61M2205/6081 ,  B23K26/0619 ,  B23K26/067 ,  B23K26/282 ,  B23K2101/06 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1632 ,  B29C65/1664 ,  B29C65/1674 ,  B29C65/1687 ,  B29C65/2046 ,  B29C65/2061 ,  B29C65/7802 ,  B29C65/7841 ,  B29C66/1142 ,  B29C66/1312 ,  B29C66/137 ,  B29C66/5221 ,  B29C66/636 ,  B29C66/71 ,  B29C66/712 ,  B29C66/723 ,  B29C66/73115 ,  B29C66/73921 ,  B29C66/81267 ,  B29C66/8226 ,  B29C66/82263 ,  B29C66/857 ,  B29C66/9121 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91218 ,  B29C66/91221 ,  B29C66/9131 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/9161 ,  B29C66/961 ,  B29K2009/06 ,  B29K2023/0608 ,  B29K2023/0616 ,  B29K2023/0633 ,  B29K2023/0641 ,  B29K2023/065 ,  B29K2023/083 ,  B29K2031/04 ,  B29L2023/007 ,  Y10S138/07 ,  Y10T156/12 ,  Y10T156/1313 ,  Y10T428/1352 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/1397 ,  B29K2023/12

摘要： A laser strikes and aseptically heats or sterilizes the end of two flexible tube ends for connection. Tube holders are pushed toward each other to bring the tube ends into contact. A weld detector checks the characteristics of the weld. A laser optics assembly may be used to change the direction of the laser and focus the laser at the tube ends. In addition, a crimping device is used to compress a single flexible tube for disconnection. The laser strikes the compressed area. The crimping device continues to pinch the area and forms a seal in the tube. The tube is separated into two tube segments, each segment has a sealed end.

摘要翻译： 激光打击并无菌加热或灭菌用于连接的两个柔性管端的末端。 管保持器彼此推动以使管端接触。 焊缝检测器检查焊缝的特性。 可以使用激光光学组件来改变激光的方向并将激光聚焦在管端。 此外，压接装置用于压缩单个柔性管以断开连接。 激光撞击压缩区域。 压接装置继续挤压该区域并在管中形成密封。 管分成两个管段，每个段具有密封端。

公开(公告)号：US06672333B2

公开(公告)日：2004-01-06

申请号：US10265930

申请日：2002-10-07

申请人： Mark E. Williamson ,  Scott R. Ariagno ,  Alan W. Marttila ,  Arnold C. Bilstad ,  Paul M. DiPerna ,  Michael R. Prisco ,  David W. Pennington ,  Atif M. Yardimci ,  Sidney T. Smith ,  Mark C. Perry ,  Marc Bellotti

发明人： Mark E. Williamson ,  Scott R. Ariagno ,  Alan W. Marttila ,  Arnold C. Bilstad ,  Paul M. DiPerna ,  Michael R. Prisco ,  David W. Pennington ,  Atif M. Yardimci ,  Sidney T. Smith ,  Mark C. Perry ,  Marc Bellotti

IPC分类号： F16K1514

CPC分类号： A61J7/0053 ,  A47G21/185 ,  A61J1/10 ,  A61J1/1475 ,  A61J7/0046 ,  A61M39/227 ,  A61M39/24 ,  A61M2039/2406 ,  A61M2039/242 ,  A61M2039/244 ,  A61M2039/2486 ,  F16K15/14 ,  F16K15/147 ,  Y10S137/907 ,  Y10T137/7781 ,  Y10T137/7836 ,  Y10T137/7882 ,  Y10T137/789

摘要： A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.

公开(公告)号：US06835186B1

公开(公告)日：2004-12-28

申请号：US09669353

申请日：2000-09-26

申请人： David W. Pennington ,  Atif M. Yardimci ,  David Amrani ,  Arnold C. Bilstad ,  Yves A. Delmotte ,  James P. Diorio ,  Robert L. Petersen ,  Joseph F. Prybell ,  James Slepicka ,  Cristina Stadler ,  John Womelsdorf

发明人： David W. Pennington ,  Atif M. Yardimci ,  David Amrani ,  Arnold C. Bilstad ,  Yves A. Delmotte ,  James P. Diorio ,  Robert L. Petersen ,  Joseph F. Prybell ,  James Slepicka ,  Cristina Stadler ,  John Womelsdorf

IPC分类号： A61M3700

CPC分类号： A61L15/32 ,  A61B17/00491 ,  A61B2017/00495 ,  A61F2310/00377 ,  A61L27/225 ,  A61L31/046 ,  B05B11/0078 ,  B05B11/02

摘要： This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid in which separate MBUs atomize the fluids. The device of the present invention includes a fluid delivery device for laparoscopically delivering fluids having two feed conduits for delivering fluid to feed ports of the mechanical breakup units, the mechanical breakup units having two feed ports for receiving fluid from the feed conduits and directing such fluid into spin chambers and funneling portions having a sloped sidewall for directing fluid from the spin chambers through an exit port. The device is suitably dimensioned for creating a spray of two fluids with different viscosities such as fibrinogen and thrombin in such a manner that the thrombin spray cone encompasses the fibrinogen spray cone at a distance of about one inch from the exit port with a 0.5 cc/second flow rate to avoid depositing unreacted fibrinogen on a surface. Other instruments such as optical fibers may be incorporated within the device.

摘要翻译： 本发明提供了用于输送体积量的第一和第二生物化学反应性流体的医疗装置，其中单独的MBU使流体雾化。 本发明的装置包括用于腹腔镜输送流体的流体输送装置，其具有用于将流体输送到机械分解单元的进料口的两个进料管道，机械分解装置具有两个进料口，用于从进料管道接收流体并引导这种流体 进入具有倾斜侧壁的旋转室和漏斗部分，用于将来自旋转室的流体引导通过出口。 该装置的适当尺寸适于产生具有不同粘度的两种流体（例如纤维蛋白原和凝血酶）的喷雾，使得凝血酶喷雾锥体以距离出口约一英寸的距离包含纤维蛋白原喷雾锥体，具有0.5cc / 第二流速以避免在表面上沉积未反应的纤维蛋白原。 诸如光纤之类的其他仪器也可以并入设备内。

公开(公告)号：US06461325B1

公开(公告)日：2002-10-08

申请号：US09386198

申请日：1999-08-31

申请人： Yves Delmotte ,  Arnold Bilstad ,  David Amrani ,  James DiOrio ,  Atif M. Yardimci ,  David W. Pennington ,  James S. Slepicka ,  Cristina Stadler

发明人： Yves Delmotte ,  Arnold Bilstad ,  David Amrani ,  James DiOrio ,  Atif M. Yardimci ,  David W. Pennington ,  James S. Slepicka ,  Cristina Stadler

IPC分类号： A61M3700

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  B05B11/0078 ,  B05B11/02

摘要： This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.

摘要翻译： 本发明提供了一种用于输送体积量的第一和第二生物化学反应性流体的医疗装置，其包括具有开口的第一容器，所述第一容器适于容纳所述第一生化反应性流体; 第二容器，具有与第一流体开口相邻的第二流体开口，第二容器适于容纳第二生化反应流体; 用于将第一和第二生化反应性流体分别雾化成具有液体能量，机械能，振动能量和电能的至少一个能量源的气溶胶的喷雾单元; 流体加压器，用于对第一和第二生化反应流体进行加压，以在压力下通过喷雾单元输送到表面上; 并且其中所述第一和第二生化反应性流体首先在所述表面上混合。

公开(公告)号：US5533412A

公开(公告)日：1996-07-09

申请号：US479247

申请日：1995-06-07

申请人： John H. Jerman ,  Ronald E. Toth ,  David A. Winchell ,  David W. Pennington

发明人： John H. Jerman ,  Ronald E. Toth ,  David A. Winchell ,  David W. Pennington

IPC分类号： G01F1/684 ,  G01F1/708 ,  G01F1/712 ,  G01F7/00 ,  G01P5/18 ,  G01F1/68

CPC分类号： G01F1/7084 ,  G01F1/6842 ,  G01F1/6845 ,  G01F1/708 ,  G01F1/712 ,  G01F7/00 ,  G01P5/18

摘要： A precise fluid flow meter fabricated by micromachining techniques measures a wide range of fluid flow rates. Two serial portions of an enclosed channel have different cross-sectional areas, and therefore different flow velocities. The fluid carries the thermal pulse through the flow channel to two sensor elements spaced apart along the channel downstream from the heating element. The transit time of the thermal pulse between the two sensor elements measures the fluid flow velocity.

摘要翻译： 通过微加工技术制造的精确流体流量计测量各种流体流速。 封闭通道的两个串联部分具有不同的横截面积，因此具有不同的流速。 流体将热脉冲通过流动通道传送到沿着加热元件下游的通道间隔开的两个传感器元件。 两个传感器元件之间的热脉冲的传播时间测量流体流速。

公开(公告)号：US08146642B2

公开(公告)日：2012-04-03

申请号：US12256986

申请日：2008-10-23

申请人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

发明人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

IPC分类号： B23K26/00

CPC分类号： A61M39/146 ,  A61M1/28 ,  A61M2205/6081 ,  B23K26/0619 ,  B23K26/067 ,  B23K26/282 ,  B23K2101/06 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1632 ,  B29C65/1664 ,  B29C65/1674 ,  B29C65/1687 ,  B29C65/2046 ,  B29C65/2061 ,  B29C65/7802 ,  B29C65/7841 ,  B29C66/1142 ,  B29C66/1312 ,  B29C66/137 ,  B29C66/5221 ,  B29C66/636 ,  B29C66/71 ,  B29C66/712 ,  B29C66/723 ,  B29C66/73115 ,  B29C66/73921 ,  B29C66/81267 ,  B29C66/8226 ,  B29C66/82263 ,  B29C66/857 ,  B29C66/9121 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91218 ,  B29C66/91221 ,  B29C66/9131 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/9161 ,  B29C66/961 ,  B29K2009/06 ,  B29K2023/0608 ,  B29K2023/0616 ,  B29K2023/0633 ,  B29K2023/0641 ,  B29K2023/065 ,  B29K2023/083 ,  B29K2031/04 ,  B29L2023/007 ,  Y10S138/07 ,  Y10T156/12 ,  Y10T156/1313 ,  Y10T428/1352 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/1397 ,  B29K2023/12

摘要： A laser strikes and aseptically heats or sterilizes the end of two flexible tube ends for connection. Tube holders are pushed toward each other to bring the tube ends into contact. A weld detector checks the characteristics of the weld. A laser optics assembly may be used to chance the direction of the lacer and focus the laser at the tube ends. In addition, a crimping device is used to compress a single flexible tube for disconnection. The laser strikes the compressed area. The crimping device continues to pinch the area and forms a seal in the tube. The tube is separated into two tube segments, each segment has a sealed end.

摘要翻译： 激光打击并无菌加热或灭菌用于连接的两个柔性管端的末端。 管保持器彼此推动以使管端接触。 焊缝检测器检查焊缝的特性。 可以使用激光光学组件来机会夹紧器的方向，并将激光器聚焦在管端。 此外，压接装置用于压缩单个柔性管以断开连接。 激光撞击压缩区域。 压接装置继续挤压该区域并在管中形成密封。 管分成两个管段，每个段具有密封端。

公开(公告)号：US06913056B2

公开(公告)日：2005-07-05

申请号：US10061835

申请日：2002-01-31

申请人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

发明人： Frank J. Landherr ,  John A. Biewer ,  Shahid Din ,  David Do ,  Rick Gilbert ,  James J. Alberti ,  David W. Pennington ,  Joe Romack

IPC分类号： A61M5/14 ,  A61L29/00 ,  A61M1/28 ,  A61M25/16 ,  A61M39/02 ,  A61M39/14 ,  B23K26/067 ,  B23K26/28 ,  B29C65/00 ,  B29C65/02 ,  B29C65/16 ,  B29C65/20 ,  B29C65/78 ,  C08J5/00 ,  C08L101/00 ,  B32B31/20 ,  H05B1/00

CPC分类号： A61M39/146 ,  A61M1/28 ,  A61M2205/6081 ,  B23K26/0619 ,  B23K26/067 ,  B23K26/282 ,  B23K2101/06 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1632 ,  B29C65/1664 ,  B29C65/1674 ,  B29C65/1687 ,  B29C65/2046 ,  B29C65/2061 ,  B29C65/7802 ,  B29C65/7841 ,  B29C66/1142 ,  B29C66/1312 ,  B29C66/137 ,  B29C66/5221 ,  B29C66/636 ,  B29C66/71 ,  B29C66/712 ,  B29C66/723 ,  B29C66/73115 ,  B29C66/73921 ,  B29C66/81267 ,  B29C66/8226 ,  B29C66/82263 ,  B29C66/857 ,  B29C66/9121 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91218 ,  B29C66/91221 ,  B29C66/9131 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/9161 ,  B29C66/961 ,  B29K2009/06 ,  B29K2023/0608 ,  B29K2023/0616 ,  B29K2023/0633 ,  B29K2023/0641 ,  B29K2023/065 ,  B29K2023/083 ,  B29K2031/04 ,  B29L2023/007 ,  Y10S138/07 ,  Y10T156/12 ,  Y10T156/1313 ,  Y10T428/1352 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/1397 ,  B29K2023/12

摘要： A laser strikes and aseptically heats or sterilizes the end of two flexible tube ends for connection. Tube holders are pushed toward each other to bring the tube ends into contact. A weld detector checks the characteristics of the weld. A laser optics assembly may be used to change the direction of the laser and focus the laser at the tube ends. In addition, a crimping device is used to compress a single flexible tube for disconnection. The laser strikes the compressed area. The crimping device continues to pinch the area and forms a seal in the tube. The tube is separated into two tube segments, each segment has a sealed end.

摘要翻译： 激光打击并无菌加热或灭菌用于连接的两个柔性管端的末端。 管保持器彼此推动以使管端接触。 焊缝检测器检查焊缝的特性。 可以使用激光光学组件来改变激光的方向并将激光聚焦在管端。 此外，压接装置用于压缩单个柔性管以断开连接。 激光撞击压缩区域。 压接装置继续挤压该区域并在管中形成密封。 管分成两个管段，每个段具有密封端。