公开(公告)号：US20130265047A1

公开(公告)日：2013-10-10

申请号：US13623104

申请日：2012-09-19

申请人： Mark Griswold ,  Nicole Sieberlich ,  Vikas Gulani ,  Dan Ma

发明人： Mark Griswold ,  Nicole Sieberlich ,  Vikas Gulani ,  Dan Ma

IPC分类号： G01R33/56

CPC分类号： G01R33/56 ,  G01R33/4828 ,  G01R33/50 ,  G01R33/56341

摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals.

摘要翻译： 描述了与NMR指纹图谱相关联的装置，方法和其它实施例。 一个示例NMR装置包括NMR逻辑，其被配置为重复地且可变地采样与物体相关联的（k，t，E）空间，以获得一组NMR信号。 一组NMR信号的成员与（k，t，E）空间中的不同点相关联。 t和/或E以非常数方式变化进行采样。 变化的参数可以包括翻转角，回波时间，RF幅度和其他参数。 NMR装置还可以包括被配置为从NMR信号产生NMR信号演化的信号逻辑，以及被配置为通过将获取的信号与参考信号进行比较的结果来表征对象中的共振物种的表征逻辑。

公开(公告)号：US08723518B2

公开(公告)日：2014-05-13

申请号：US13051044

申请日：2011-03-18

申请人： Nicole Seiberlich ,  Dan Ma ,  Vikas Gulani ,  Mark Griswold

发明人： Nicole Seiberlich ,  Dan Ma ,  Vikas Gulani ,  Mark Griswold

IPC分类号： G01R33/44 ,  G01R33/56 ,  G01R33/48 ,  G01R33/563 ,  G01R33/50

CPC分类号： G01R33/543 ,  G01R33/4828 ,  G01R33/50 ,  G01R33/54 ,  G01R33/56 ,  G01R33/56341

摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons.

摘要翻译： 描述了与NMR指纹图谱相关联的装置，方法和其它实施例。 一个示例NMR装置包括NMR逻辑，其被配置为重复地且可变地采样与物体相关联的（k，t，E）空间，以获得一组NMR信号。 一组NMR信号的成员与（k，t，E）空间中的不同点相关联。 t和/或E以非常数方式变化进行采样。 变化的参数可以包括翻转角，回波时间，RF幅度和其他参数。 NMR装置还可以包括被配置为从NMR信号产生NMR信号演化的信号逻辑，被配置为将信号演进与已知的，模拟或预测的信号演变进行比较的匹配逻辑，以及被配置为表征共振物种的表征逻辑 在对象中作为信号进化比较的结果。

公开(公告)号：US20120235678A1

公开(公告)日：2012-09-20

申请号：US13051044

申请日：2011-03-18

申请人： NICOLE SEIBERLICH ,  Dan Ma ,  Vikas Gulani ,  Mark Griswold

发明人： NICOLE SEIBERLICH ,  Dan Ma ,  Vikas Gulani ,  Mark Griswold

IPC分类号： G01R33/44

CPC分类号： G01R33/543 ,  G01R33/4828 ,  G01R33/50 ,  G01R33/54 ,  G01R33/56 ,  G01R33/56341

摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons.

摘要翻译： 描述了与NMR指纹图谱相关联的装置，方法和其它实施例。 一个示例NMR装置包括NMR逻辑，其被配置为重复地且可变地采样与物体相关联的（k，t，E）空间，以获得一组NMR信号。 一组NMR信号的成员与（k，t，E）空间中的不同点相关联。 t和/或E以非常数方式变化进行采样。 变化的参数可以包括翻转角，回波时间，RF幅度和其他参数。 NMR装置还可以包括被配置为从NMR信号产生NMR信号演化的信号逻辑，被配置为将信号演进与已知的，模拟或预测的信号演变进行比较的匹配逻辑，以及被配置为表征共振物种的表征逻辑 在对象中作为信号进化比较的结果。

公开(公告)号：US08558546B2

公开(公告)日：2013-10-15

申请号：US13085690

申请日：2011-04-13

申请人： Mark Griswold ,  Nicole Seiberlich ,  Dan Ma

发明人： Mark Griswold ,  Nicole Seiberlich ,  Dan Ma

IPC分类号： G01V3/00

CPC分类号： G01R33/50 ,  G01R33/5611 ,  G01R33/5614

摘要： Apparatus, methods, and other embodiments associated with multi-scale orthogonal matching pursuit (OMP) for magnetic resonance imaging (MRI) relaxometry are described. One example method includes controlling a nuclear magnetic resonance (NMR) apparatus to cause selected nuclei in an item to resonate by applying radio frequency (RF) energy to the item and then acquiring multiple series of magnetic resonance (MR) images of the item, the series of MR images having different scales. The example method includes controlling the NMR apparatus to produce a combined signal evolution from a first signal evolution associated with a first series of MR images and a second signal evolution associated with a second series of MR images and to characterize relaxation of the selected nuclei in the item as a function of an OMP that compares the combined signal evolution to a set of combined comparative signal evolutions.

摘要翻译： 描述了与用于磁共振成像（MRI）松弛度测量的多尺度正交匹配追踪（OMP）相关联的装置，方法和其它实施例。 一个示例性方法包括通过对物品施加射频（RF）能量，然后获取物品的多个系列的磁共振（MR）图像来控制核磁共振（NMR）装置来引起物品中的选定的核共振， 具有不同尺度的一系列MR图像。 该示例性方法包括控制NMR装置以从与第一系列MR图像相关联的第一信号演变和与第二系列MR图像相关联的第二信号演变产生组合信号演变，并且表征所选择的核的松弛 作为OMP的函数的项目，其将组合信号演进与一组组合的比较信号演变进行比较。

公开(公告)号：US08717023B2

公开(公告)日：2014-05-06

申请号：US13236795

申请日：2011-09-20

申请人： Mark Griswold ,  Dan Ma ,  Kecheng Liu

发明人： Mark Griswold ,  Dan Ma ,  Kecheng Liu

IPC分类号： G01V3/00

CPC分类号： G01R33/448 ,  G01R33/50 ,  G01R33/56341

摘要： Apparatus, methods, and other embodiments associated with self-justification fitting for magnetic resonance imaging (MRI) relaxation parameter quantification are described. One example nuclear magnetic resonance (NMR) apparatus includes a self-justification fitting logic configured to selectively include and exclude data points from a set of data points associated with NMR signals based, at least in part, on their impact on a fit attribute (e.g., standard deviation). In one embodiment, the self-justification is configured to select a subset of data points from the set of data points as a function of values for a fit attribute computed from fitting at least two different subsets of data points from the set of data points to a known NMR signal evolution.

摘要翻译： 描述了与用于磁共振成像（MRI）松弛参数定量的自适应装置相关联的装置，方法和其它实施例。 一个例子，核磁共振（NMR）装置包括自对准拟合逻辑，其被配置为至少部分地基于它们对拟合属性的影响（例如，对于核心）来选择性地包括和排除与NMR信号相关联的一组数据点的数据点。 ，标准偏差）。 在一个实施例中，自适应被配置为根据从至少两个不同子集的数据点从数据点集合到数据点拟合的拟合属性的值来从数据点集合中选择数据点的子集， 已知的NMR信号进化。

公开(公告)号：US20120268123A1

公开(公告)日：2012-10-25

申请号：US13236795

申请日：2011-09-20

申请人： Mark Griswold ,  Dan Ma ,  Kecheng Liu

发明人： Mark Griswold ,  Dan Ma ,  Kecheng Liu

IPC分类号： G01R33/44

CPC分类号： G01R33/448 ,  G01R33/50 ,  G01R33/56341

摘要： Apparatus, methods, and other embodiments associated with self-justification fitting for magnetic resonance imaging (MRI) relaxation parameter quantification are described. One example nuclear magnetic resonance (NMR) apparatus includes a self-justification fitting logic configured to selectively include and exclude data points from a set of data points associated with NMR signals based, at least in part, on their impact on a fit attribute (e.g., standard deviation). In one embodiment, the self-justification is configured to select a subset of data points from the set of data points as a function of values for a fit attribute computed from fitting at least two different subsets of data points from the set of data points to a known NMR signal evolution.

摘要翻译： 描述了与用于磁共振成像（MRI）松弛参数定量的自适应装置相关联的装置，方法和其它实施例。 一个例子，核磁共振（NMR）装置包括自对准拟合逻辑，其被配置为至少部分地基于它们对拟合属性的影响（例如，对于核心）来选择性地包括和排除与NMR信号相关联的一组数据点的数据点。 ，标准偏差）。 在一个实施例中，自适应被配置为根据从至少两个不同子集的数据点从数据点集合到数据点拟合的拟合属性的值来从数据点集合中选择数据点的子集， 已知的NMR信号进化。

公开(公告)号：US09470767B2

公开(公告)日：2016-10-18

申请号：US13444911

申请日：2012-04-12

申请人： Mark Griswold ,  Matthew Riffe

发明人： Mark Griswold ,  Matthew Riffe

IPC分类号： G01R33/58 ,  G01R33/24 ,  G01R33/36 ,  G01R33/565

CPC分类号： G01R33/243 ,  G01R33/3692 ,  G01R33/56563 ,  G01R33/56572 ,  G01R33/58

摘要： Apparatus, methods, and other embodiments associated with wireless magnetic field monitoring (wMFM) in magnetic resonance imaging (MRI) are described. One example apparatus includes a wMFM module configured to receive an MFM signal from an MFM probe and to wirelessly transmit modulated MFM signals produced from the received MFM signals to an MRI apparatus. The MRI apparatus is configured with a wireless receiver that receives and processes the modulated MFM signals into information used in an image reconstruction. The MRI apparatus includes an MRI reconstruction logic configured to produce an MR image from the MRI signal based, at least in part, on the magnetic field measurement information.

摘要翻译： 描述了与磁共振成像（MRI）中的无线磁场监测（wMFM）相关联的装置，方法和其它实施例。 一个示例性设备包括被配置为从MFM探测器接收MFM信号并将从所接收的MFM信号产生的调制的MFM信号无线发射到MRI设备的wMFM模块。 MRI装置配置有无线接收机，其将调制的MFM信号接收并处理成用于图像重构的信息。 MRI装置包括被配置为至少部分地基于磁场测量信息从MRI信号产生MR图像的MRI重构逻辑。

公开(公告)号：US07558614B2

公开(公告)日：2009-07-07

申请号：US11408552

申请日：2006-04-21

申请人： Mark Griswold ,  Stephan Kannengiesser

发明人： Mark Griswold ,  Stephan Kannengiesser

IPC分类号： A61B5/05 ,  G01V3/00

CPC分类号： G01R33/5611 ,  G01R33/5612 ,  G01R33/583

摘要： In a method for determining transmission coil-specific RF excitation pulses for component coils of a transmission coil array for accelerated, PPA-based volume-selective magnetic resonance excitation of a tissue region of a patient, and a magnetic resonance tomography apparatus operating according to the method, a first series of volume-selective RF excitation pulses along a first transmission trajectory in transmission κ-space is successively individually radiated by the component coils of the transmission coil array and the resulting magnetic resonance signals are received, and a second series of volume-selected RF excitation pulses along a further reduced transmission trajectory in transmission κ-space is simultaneously radiated by all component coils of the transmission coil array and the resulting magnetic resonance signals are received, and a complete transmission trajectory in transmission κ-space is then determined from which combination coefficients are calculated, and the coil specific RF excitation pulses are then calculated from the combination coefficients in order to produce a desired excitation profile.

摘要翻译： 在用于确定用于加速的基于PPA的体积选择性磁共振激励患者的组织区域的传输线圈阵列的分量线圈的传输线圈特定RF激励脉冲的方法中，以及根据该方法操作的磁共振断层摄影装置 方法中，沿传输线圈阵列中的第一传输轨迹的第一系列体积选择性RF激励脉冲被传输线圈阵列的分量线圈连续单独辐射，并且接收所得到的磁共振信号，并且接收第二系列体积 通过传输线圈阵列的所有分量线圈同时辐射沿着传输卡巴空间中进一步减小的传输轨迹的选择的RF激励脉冲，并且接收所得到的磁共振信号，然后确定传输卡巴空间中的完整传输轨迹 从中计算组合系数， 然后从组合系数计算线圈特定的RF激励脉冲，以便产生期望的激励曲线。

公开(公告)号：US06505149B1

公开(公告)日：2003-01-07

申请号：US09365387

申请日：1999-08-02

申请人： Mark Griswold ,  Jen-Tien Yen

发明人： Mark Griswold ,  Jen-Tien Yen

IPC分类号： G06F1750

CPC分类号： G06F17/5022 ,  H04L7/0008

摘要： A method for verifying a source-synchronous communication interface of a processor is disclosed. A software model of a first device having a source-synchronous communication interface and a software model of a second device capable of communicating with the first device via the source-synchronous communication interface are provided. The source-synchronous communication interface includes an applied clock line, an address line, an echo clock line, and a data line. A simulation of a data request from the first device model to the second device model via an applied clock signal along with an address on the applied clock line and the address line is initially performed. The requested data is then received by the first device model from the second device model via the data line after various delays between the applied clock signal and an echo clock signal on the applied clock line and the echo clock line, respectively. Finally, the requested data received by the first device model is verified as to its veracity.

摘要翻译： 公开了一种用于验证处理器的源同步通信接口的方法。 提供具有源同步通信接口和能够经由源同步通信接口与第一设备进行通信的第二设备的软件模型的第一设备的软件模型。 源同步通信接口包括应用的时钟线，地址线，回波时钟线和数据线。 最初执行通过施加的时钟信号以及所施加的时钟线和地址线上的地址从第一设备模型到第二设备模型的数据请求的模拟。 然后，在所施加的时钟信号和所应用的时钟线和回波时钟线上的回波时钟信号之间的各种延迟之后，所请求的数据然后经由数据线从第二设备模型接收第一设备模型。 最后，验证第一设备模型接收到的请求数据的真实性。

公开(公告)号：US09086466B2

公开(公告)日：2015-07-21

申请号：US13446361

申请日：2012-04-13

申请人： Mark Griswold ,  Gregory R. Lee

发明人： Mark Griswold ,  Gregory R. Lee

IPC分类号： G01R33/48 ,  G01R33/563

CPC分类号： G01R33/4826 ,  G01R33/563

摘要： Example apparatus and methods order projections in a 3D MRI acquisition to achieve improved equidistant spacing or to achieve improved adherence to a target distribution. The equidistant or target spacing may exist in k-space and/or in kt-space. In one embodiment, the improved equidistant spacing is a substantially uniform spacing. The substantially uniform spacing may be achieved using a modification of a charge repulsion analysis that treats points of projections that intersect the surface of a 3D volume to be imaged as point charges distributed on the 3D volume. In another embodiment, the target spacing may be uniform, non-uniform, uniform in parts and non-uniform in other parts, and other combinations.

摘要翻译： 示例性装置和方法在3D MRI采集中排序投影以实现改进的等距间距或实现改善对目标分布的依从性。 等距或目标间距可存在于k空间和/或kt空间中。 在一个实施例中，改进的等距间距是基本均匀的间距。 可以使用电荷排斥分析的修改来实现基本上均匀的间隔，所述电荷排斥分析将待映射的3D体积的表面相交的投影点作为分布在3D体积上的点电荷进行处理。 在另一个实施例中，目标间隔可以是均匀的，不均匀的，部分均匀的，在其他部分中不均匀，以及其它组合。