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公开(公告)号：US20050026256A1
公开(公告)日：2005-02-03
申请号：US10940867
申请日：2004-09-14
申请人： Mark Gurney , Michael Bienkowski , Robert Heinrikson , Luis Parodi , Riqiang Yan
发明人： Mark Gurney , Michael Bienkowski , Robert Heinrikson , Luis Parodi , Riqiang Yan
IPC分类号： G01N33/50 , A61K38/48 , A61K45/00 , A61P25/28 , C07K20060101 , C07K5/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K19/00 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/50 , C12N9/64 , C12N9/82 , C12N15/09 , C12N15/12 , C12N15/57 , C12N15/62 , C12N15/63 , C12N15/79 , C12N15/85 , C12N15/86 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q20060101 , C12Q1/37 , C12R1/19 , G01N20060101 , G01N33/15 , G01N33/68 , C12Q1/68 , C07H21/04 , C07K14/705
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。
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2.发明申请公开(公告)号：US20050080232A1
公开(公告)日：2005-04-14
申请号：US10477076
申请日：2001-05-09
申请人： Mark Gurney , Michael Bienkowski , Robert Heinrikson , Luis Parodi , Riqiang Yan
发明人： Mark Gurney , Michael Bienkowski , Robert Heinrikson , Luis Parodi , Riqiang Yan
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。 本发明还提供了修饰的APP蛋白和相关核酸，肽，载体，细胞和细胞分离物以及特别可用于鉴定用于治疗或预防阿尔茨海默病的候选治疗剂的测定。
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公开(公告)号：US20080090260A1
公开(公告)日：2008-04-17
申请号：US11753331
申请日：2007-05-24
申请人： Riqiang Yan , Alfredo Tomasselli , Mark Gurney , Thomas Emmons , Michael Bienkowski , Robert Heinrikson
发明人： Riqiang Yan , Alfredo Tomasselli , Mark Gurney , Thomas Emmons , Michael Bienkowski , Robert Heinrikson
CPC分类号： C07K14/4711 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/4702 , C12Q1/37 , G01N2333/96425 , G01N2500/02
摘要： The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
摘要翻译： 本发明涉及用于Hu-Asp的新型底物。 更具体地，本发明提供了包含β-分泌酶切割位点的肽底物和融合多肽底物。 公开了制备和使用肽的方法和组合物。
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公开(公告)号：US20050096457A1
公开(公告)日：2005-05-05
申请号：US10801493
申请日：2004-03-16
申请人： Riqiang Yan , Alfredo Tomasselli , Mark Gurney , Thomas Emmons , Michael Bienkowski , Robert Heinrikson
发明人： Riqiang Yan , Alfredo Tomasselli , Mark Gurney , Thomas Emmons , Michael Bienkowski , Robert Heinrikson
IPC分类号： G01N33/50 , A61K45/00 , A61P25/28 , A61P43/00 , C07K2/00 , C07K5/00 , C07K5/103 , C07K7/06 , C07K7/08 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/37 , G01N33/15
CPC分类号： C07K14/4711 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/4702 , C12Q1/37 , G01N2333/96425 , G01N2500/02
摘要： The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
摘要翻译： 本发明涉及用于Hu-Asp的新型底物。 更具体地，本发明提供了包含β-分泌酶切割位点的肽底物和融合多肽底物。 公开了制备和使用肽的方法和组合物。
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公开(公告)号：US20050282251A1
公开(公告)日：2005-12-22
申请号：US11057732
申请日：2005-02-14
CPC分类号： C12Y302/01166 , A61K38/00 , A61K2039/505 , C12N9/2402
摘要： The present invention provides a cDNA encoding a heretofore unknown enzyme termed heparanase II; constructs and recombinant host cells incorporating the cDNA; the heparanase II polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing.
摘要翻译： 本发明提供编码称为乙酰肝素酶II的迄今未知的酶的cDNA; 构建体和掺入cDNA的重组宿主细胞; 由该基因编码的乙酰肝素酶II多肽; 针对多肽的抗体; 以及制作和使用上述所有方法。
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6.发明申请公开(公告)号：US20050196398A1
公开(公告)日：2005-09-08
申请号：US10817979
申请日：2004-04-05
申请人： Mark Gurney , Michael Bienkowski
发明人： Mark Gurney , Michael Bienkowski
IPC分类号： A61P25/28 , C07K14/47 , C12N1/21 , C12N9/64 , C12N15/57 , C12Q1/37 , C12Q1/68 , A61K39/395 , C07H21/04 , C12N15/09
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the α-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。 还提供了切割APP的α-分泌酶位点的酶。 本发明还提供了修饰的APP蛋白和相关核酸，肽，载体，细胞和细胞分离物以及特别可用于鉴定用于治疗或预防阿尔茨海默病的候选治疗剂的测定。
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