摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.
摘要:
The present invention relates to compounds having a structure according to Formula (I) wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要:
The present invention is directed to quinolone derivatives, useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes
摘要:
3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
摘要:
A flow control device including a flow channel having a housing defining an inside surface, the inside surface having an irregular helical structure of constant orthogonal cross-sectional dimensions.
摘要:
The invention discloses method for determining hydraulic parameters and water inflow in the erosion stage of gravel soil, comprising: calculate the soil particle content P and the soil porosity n of each grade of particle size a, and draw the PSD curve of each grade of particle size and the soil particle content P of each grade of particle size and the PSD curve cluster of each grade of particle size and the soil particle content P of each grade of particle size in each erosion stage; calculate the equivalent diameter Dh of the soil particle, and calculate the minimum equivalent pore diameter d0 of the soil particle; calculate the critical hydraulic gradient icr of particle erosion at each stage; calculate the permeability coefficient kh; calculate the seepage flow velocity ν and the total seepage flow Q.
摘要:
The overlay human interactive proof system (“OHIPS”) and techniques described herein operate in conjunction with any known or later developed computer-based applications or services to provide secure access to resources by reliably differentiating between human and non-human users. Humans have a generally superior ability to differentiate misaligned characters or objects from correctly aligned ones. As such, the OHIP splits an image including one or more visual objects into two or more partial images to form a HIP. The partial images may also be further split into groups of sub-partial images, and/or the partial images (or the sub-partial images) may be moved, so that at any given alignment position, a user can recognize only some visual objects. A user is instructed to reassemble the partial images at one or more predetermined alignment positions using a GUI, and the user is asked to identify information regarding one or more visible objects.