摘要:
Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要:
A universal device for securing a catheter on a patient includes a base which optionally has one or more locating elements for positioning or securing a catheter or catheter fitting of various shapes or sizes. The base optionally includes a recessed or flat receiving area defined by locating elements arranged in any configuration suitable to hold or receive a catheter or catheter fitting, e.g., in a tapering or V shaped formation. Additional locating elements may be positioned elsewhere on the base for receiving or holding a flange or wing of a catheter fitting and preventing its movement in various directions. The base optionally has an angled surface to maintain the desired angle for catheters or catheter fittings in a patient. A cover is removably or permanently connected to the base and may optionally have one or more top openings for receiving tabs or extensions of a catheter fitting.
摘要:
A method is provided for producing reduced-fat components that may be used to make reduced and low-fat processed cheese, natural cheese or other reduced and low-fat food products. The reduced-fat flavor components are produced by extraction of fat from full-fat biogenerated cheese flavor components. Alternatively, natural biogenerated cheese flavor components are produced with reduced amounts of fat. Additionally, reduced-fat cheddar cheese can be derived from 1% milk.
摘要:
An apparatus for adjustably securing a boat accessory to a boat. A first member has a plug and a second member has a socket. The plug has a rosette shape with rounded protrusions and the socket has a corresponding mating shape. Both the plug and the socket have openings for a fastener to secure the plug in the socket. The first member is one of a mounting base and an accessory base, and the second member is the other one. In one embodiment, an extension is positioned adjacent the plug so as to separate the first and second members. In another embodiment, the extension has a plug on each end and the first and second members have sockets. In another such embodiment, the extension has two members joined with a rosette-shaped plug and socket.
摘要:
The inventive subject matter relates to multi-layered massage devices for providing a pleasurable massage sensation; for simulating a lubricant-aided massage on the skin of an animal, without the use of a lubricant; for treating or preventing a cause or a symptom of a disease, disorder, or condition in an animal in need thereof, by administering a therapeutic massage; for genital stimulation for the pleasure of a male or female human; and for producing a low friction interface between a surface of a human body and a surface of another object.
摘要:
The present inventive subject matter relates to devices and methods for promoting or enhancing male erectile function, and for treating erectile dysfunction.
摘要:
A vector modulator including an offset QPSK modulator operative for receiving input data and generating a first output signal representing the modulation to be imposed on a carrier signal to effect offset QPSK modulation of the input signal and a second output signal representing an amplitude of the input data; and a frequency modulator including a sigma-delta modulator, operative for receiving the first output signal generated by the offset QPSK modulator, and generating a control signal representing the desired frequency of the carrier signal such that the carrier signal represents the input signal offset QPSK modulated. The vector modulator also includes a phase-lock loop circuit having a voltage controlled oscillator for generating the carrier signal and a programmable frequency divider for receiving the control signal as an input signal and for changing the frequency of the carrier signal in accordance with the control signal, and an amplifier having a variable gain which is operative for receiving and amplifying the carrier signal output by the phase-lock loop circuit in accordance with the amplitude of the second output signal.
摘要:
Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要:
An apparatus for orienting a directional antenna of a remote ground terminal which receives a signal from a satellite. The apparatus includes a down-converter for demodulating the signal to an intermediate frequency signal. The down-converter includes an automatic gain control loop for maintaining the intermediate frequency signal at a predetermined power level. The apparatus further includes a controller coupled to the down-converter so as to monitor a voltage level of the automatic gain control loop. The apparatus also includes a controller operative to generate a difference signal corresponding to the difference of the voltage level when the signal from the satellite is being received by the down-converter from when the signal from the satellite is not received by the down-converter. The difference signal varies proportionally with the amplitude of the signal from the satellite received by the down-converter.