公开(公告)号：US09330820B2

公开(公告)日：2016-05-03

申请号：US13873961

申请日：2013-04-30

Applicant: Mark G. Allen ,  Seong-O Choi ,  Jung-Hwan Pauk ,  Xiaosong Wu ,  Yanzhu Zhao ,  Yong-Kyu Yoon ,  Swaminathan Rajaraman

Inventor： Mark G. Allen ,  Seong-O Choi ,  Jung-Hwan Pauk ,  Xiaosong Wu ,  Yanzhu Zhao ,  Yong-Kyu Yoon ,  Swaminathan Rajaraman

IPC: H01B13/00 ,  A61B5/00 ,  A61M37/00 ,  H05K1/02 ,  C25D1/00 ,  C25D1/10 ,  C25D5/02 ,  A61N1/32 ,  H05K3/40 ,  H05K3/20

CPC classification number: B32B3/30 ,  A61B5/685 ,  A61B2562/125 ,  A61M37/0015 ,  A61M2037/0053 ,  A61N1/327 ,  C25D1/003 ,  C25D1/10 ,  C25D5/022 ,  H01B13/00 ,  H05K1/02 ,  H05K3/20 ,  H05K3/4007 ,  H05K2201/0367 ,  H05K2201/09045 ,  H05K2201/09118 ,  H05K2203/0113 ,  Y10T428/2958 ,  Y10T428/298

Abstract: Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer.

Abstract translation: 提供用于制造三维导电结构的方法。 还提供三维导电微结构。 该方法可以包括提供具有限定三维结构的至少一个微压缩的模具; 用至少一种基底材料填充模具的微压缩; 模制所述至少一种基底材料以形成基底; 以及在模制过程期间或在模制过程之后沉积和图案化至少一个导电层以形成导电结构。 在一个实施例中，三维导电微结构包括电功能微针阵列，其包括两个或更多个微针，每个微针包括高纵横比，至少基本上被导电层涂覆的聚合物三维衬底结构。

公开(公告)号：US09032900B2

公开(公告)日：2015-05-19

申请号：US13870050

申请日：2013-04-25

Applicant: Ari Glezer ,  Lora G. Weiss ,  Mark G. Allen

Inventor： Ari Glezer ,  Lora G. Weiss ,  Mark G. Allen

IPC: B63G8/26 ,  B63G8/00 ,  B63G8/08 ,  B63G8/14 ,  B63H1/30 ,  B63H1/37 ,  B63G8/18 ,  B63H1/36 ,  B63B7/08 ,  B63G13/02

CPC classification number: B63G8/26 ,  B63B7/08 ,  B63B2211/02 ,  B63G8/001 ,  B63G8/08 ,  B63G8/14 ,  B63G8/18 ,  B63G2008/002 ,  B63G2013/022 ,  B63H1/30 ,  B63H1/36 ,  B63H1/37

Abstract: Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.

Abstract translation: 公开了船用车辆系统和方法。 船舶可以浮力控制，能够有效，延长使用船用车辆。 浮力致动可以实现船舶的滚动，俯仰和偏航，以及任何方向的平移。 一个或多个弹性囊可以设置在船用车辆上或船上。 气囊可以选择性地膨胀和放气以控制船用车辆的运动。

公开(公告)号：US20130305978A1

公开(公告)日：2013-11-21

申请号：US13870050

申请日：2013-04-25

Applicant: Ari Glezer ,  Lora G. Weiss ,  Mark G. Allen

Inventor： Ari Glezer ,  Lora G. Weiss ,  Mark G. Allen

IPC: B63G8/26

CPC classification number: B63G8/26 ,  B63B7/08 ,  B63B2211/02 ,  B63G8/001 ,  B63G8/08 ,  B63G8/14 ,  B63G8/18 ,  B63G2008/002 ,  B63G2013/022 ,  B63H1/30 ,  B63H1/36 ,  B63H1/37

Abstract: Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.

Abstract translation: 公开了船用车辆系统和方法。 船舶可以浮力控制，能够有效，延长使用船用车辆。 浮力致动可以实现船舶的滚动，俯仰和偏航，以及任何方向的平移。 一个或多个弹性囊可以设置在船用车辆上或船上。 气囊可以选择性地膨胀和放气以控制船用车辆的运动。

公开(公告)号：US20120313649A1

公开(公告)日：2012-12-13

申请号：US13588518

申请日：2012-08-17

Applicant: Jin Woo Park ,  Florent Cros ,  Mark G. Allen

Inventor： Jin Woo Park ,  Florent Cros ,  Mark G. Allen

IPC: G01R27/28

CPC classification number: H02J50/00 ,  A61B5/0031 ,  A61B2560/0219 ,  G01K13/00 ,  G01L1/00 ,  G01L7/00 ,  H02J5/005 ,  H02J7/025

Abstract: Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

Abstract translation: 无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。 一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。 电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。 转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。 此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

公开(公告)号：US08257324B2

公开(公告)日：2012-09-04

申请号：US11805096

申请日：2007-05-21

Applicant: Mark R. Prausnitz ,  Mark G. Allen ,  Inder-Jeet Gujral

Inventor： Mark R. Prausnitz ,  Mark G. Allen ,  Inder-Jeet Gujral

IPC: A61M5/32

CPC classification number: A61M37/0015 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/150984 ,  A61B17/205 ,  A61B2090/0814 ,  A61M5/422 ,  A61M2037/0023 ,  A61M2037/003 ,  B33Y80/00

Abstract: Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles, In one embodiment, the reservoir is a syringe or pump connected to the substrate.

Abstract translation: 提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。 所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。 储存器可以由可变形的，优选弹性的材料形成。 该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。在一个实施例中，储存器是连接到基板的注射器或泵。

公开(公告)号：US08101114B2

公开(公告)日：2012-01-24

申请号：US12299092

申请日：2007-04-30

Applicant: Jung-hwan Park ,  Mark G. Allen ,  Mark R. Prausnitz

Inventor： Jung-hwan Park ,  Mark G. Allen ,  Mark R. Prausnitz

IPC: A61K9/14

CPC classification number: B29C35/0261 ,  A61M37/0015 ,  B29C35/0805 ,  B29C67/205 ,  B29C2035/0827 ,  B29K2105/251 ,  B29K2995/006 ,  B29L2031/7544

Abstract: Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.

Abstract translation: 提供各种装置，布置和方法来产生包括微结构的各种结构。 在一个实施例中，提供了一种用于产生微结构的方法，包括将多个颗粒包裹在微胶片中，然后将能量施加到微镜中的颗粒。 作为施加能量的结果，在微粒中形成微结构。 此后，将微观结构从微型金属中除去。

公开(公告)号：US20100312191A1

公开(公告)日：2010-12-09

申请号：US12853082

申请日：2010-08-09

Applicant: Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

Inventor： Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

IPC: A61M5/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61B2010/008 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B33Y80/00 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

Abstract translation: 提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。 在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。 还提供制造这些装置的方法，其可以包括中空和/或多孔微针。 用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。 在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。 该装置优选地还包括用于控制通过微针的材料流动的装置。 这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

公开(公告)号：US20090115396A1

公开(公告)日：2009-05-07

申请号：US12349606

申请日：2009-01-07

Applicant: Mark G. Allen ,  Michael Ellis ,  Jason Kroh ,  Donald J. Miller

Inventor： Mark G. Allen ,  Michael Ellis ,  Jason Kroh ,  Donald J. Miller

IPC: G01R23/12 ,  G01D1/14

CPC classification number: G01R23/12 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01D21/00 ,  G01F15/066 ,  G01R23/145

Abstract: The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

Abstract translation: 本发明通过调节激励信号的相位和频率直到激励信号的频率与传感器的谐振频率相匹配来确定传感器的谐振频率。 该系统以低占空比激励传感器，具有预定频率或一组频率和预定幅度的RF能量门控突发。 激励信号通过磁耦合耦合到传感器，并且感应传感器中的电流，其以传感器的谐振频率振荡。 系统通过磁耦合接收传感器的响铃响应，并确定传感器的谐振频率，用于计算测量的物理参数。 该系统使用一对锁相环来调节激励信号的相位和频率。

公开(公告)号：US20080265142A1

公开(公告)日：2008-10-30

申请号：US12166222

申请日：2008-07-01

Applicant: William A. VON DRASEK ,  Shawn D. Wehe ,  Mark G. Allen

Inventor： William A. VON DRASEK ,  Shawn D. Wehe ,  Mark G. Allen

IPC: G01J1/04

CPC classification number: G01N21/39 ,  G01N2201/12

Abstract: A gas species monitoring system includes a laser, a fiber amplifier configured to receive an input signal from the laser and generate an amplified signal, and a variable optical attenuation system configured to receive at least a portion of the amplified signal and generate an attenuated signal for delivery to a measurement point, where the measurement point includes a gaseous fluid. The system further includes a detector configured to receive and process a signal from the measurement point so as to obtain a measured signal that correlates with the presence of a gas species within the gaseous fluid at the measurement point, and a processor in communication with at least the variable optical attenuation system and the detector. The processor controls the variable optical attenuation system based upon the measured signal.

Abstract translation: 气体种类监测系统包括激光器，被配置为从激光器接收输入信号并产生放大信号的光纤放大器，以及可变光衰减系统，被配置为接收放大信号的至少一部分并产生衰减信号 输送到测量点，其中测量点包括气态流体。 该系统还包括检测器，其被配置为接收并处理来自测量点的信号，以便获得与测量点处的气态流体内的气体种类的存在相关的测量信号，以及至少与 可变光衰减系统和检测器。 处理器基于测量信号控制可变光衰减系统。

公开(公告)号：US07439723B2

公开(公告)日：2008-10-21

申请号：US11748053

申请日：2007-05-14

Applicant: Mark G. Allen ,  Michael Ellis ,  Jason Kroh ,  Donald J. Miller

Inventor： Mark G. Allen ,  Michael Ellis ,  Jason Kroh ,  Donald J. Miller

IPC: G01R23/12 ,  G01R35/00

CPC classification number: G01R23/145 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01F15/066 ,  G01R23/12 ,  H04L2027/0028 ,  H04L2027/0055 ,  H04L2027/0067

Abstract: The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

Abstract translation: 本发明通过调节激励信号的相位和频率直到激励信号的频率与传感器的谐振频率相匹配来确定传感器的谐振频率。 该系统以低占空比激励传感器，具有预定频率或一组频率和预定幅度的RF能量门控突发。 激励信号通过磁耦合耦合到传感器，并且感应传感器中的电流，其以传感器的谐振频率振荡。 系统通过磁耦合接收传感器的响铃响应，并确定传感器的谐振频率，用于计算测量的物理参数。 该系统使用一对锁相环来调节激励信号的相位和频率。