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1.发明申请RECOVERY OF ASPARTYL (ASPARAGINYL) BETA HYDROXYLASE (HAAH) FROM AN EXOSOMAL FRACTION OF HUMAN SERA FROM CANCER PATIENTS 审中-公开从CANCER患者的人类血清外分泌物中回收ASPARTYL（ASPARAGINYL）BETA羟基酶（HAAH）公开(公告)号：US20160077098A1
公开(公告)日：2016-03-17
申请号：US14853254
申请日：2015-09-14
申请人： Mark Semenuk , Hossein Ghanbari , Michael Lebowitz
发明人： Mark Semenuk , Hossein Ghanbari , Michael Lebowitz
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , G01N33/57492 , G01N2333/90245
摘要： The present invention encompasses methods of detecting exosomes comprising Aspartyl-[Asparaginyl]-β-hydroxylase (HAAH). The present invention contemplates is further directed to methods diagnosing cancer by identifying exosomes comprising HAAH.
摘要翻译： 本发明包括检测包含天冬氨酰 - [Asparaginyl] - ＆bgr。 - 羟化酶（HAAH）的外来体的方法。 本发明进一步涉及通过鉴定包含HAAH的外来体来诊断癌症的方法。
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公开(公告)号：US20060160826A1
公开(公告)日：2006-07-20
申请号：US10835668
申请日：2004-04-30
IPC分类号： A61K31/4965 , A61K31/44 , A61K31/505 , A61K31/426 , A61K31/421 , A61K31/4196 , A61K31/4166
CPC分类号： A61K31/44 , A61K31/4166 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/4965 , A61K31/505
摘要： The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of the present invention relates to methods of treating specific ischemia-related conditions, including but not limited to Alzheimer's disease, Parkinson's disease, Coronary artery bypass graft surgery, Global cerebral ischemia due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage, hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture of intracranial vascular abnormalities, subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms, hypertensive encephalopathy, carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic thromboembolism, spinal stroke and spinal cord injury, diseases of cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular degeneration, myocardial infarction, cardiac ischemia and superaventicular tachyarrhytmia.
摘要翻译： 本发明涉及通过向需要这种方法的患者施用某些缩氨基硫脲化合物来治疗缺血相关病症的方法。 本发明的优选实施方案涉及治疗特定缺血相关病症的方法，包括但不限于阿尔茨海默氏病，帕金森病，冠状动脉旁路移植手术，由于心脏停搏引起的全球性脑缺血，局灶性脑梗死，脑出血，出血 梗死，高血压性出血。 由于颅内血管异常破裂引起的出血，颅内动脉瘤破裂引起的蛛网膜下腔出血，高血压性脑病，颈动脉狭窄或闭塞，导致脑缺血，心源性血栓栓塞，脊髓卒中和脊髓损伤，脑血管疾病：动脉粥样硬化 ，血管炎，黄斑变性，心肌梗死，心脏缺血和超表型性快速性心律失常。
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公开(公告)号：US20060194810A1
公开(公告)日：2006-08-31
申请号：US11282314
申请日：2005-11-18
IPC分类号： A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/4172
CPC分类号： A61K31/44 , A61K31/175 , A61K31/4172 , A61K31/426 , A61K31/4402 , A61K31/4965 , C07D213/53 , C07D213/73 , C07D233/64 , C07D241/12 , C07D277/28
摘要： The present invention relates to methods of treating or preventing ischemia-related (i.e., neural cell hypoxia and/or hypoglycemic) conditions by administering to a patient in need thereof certain thiosemicarbazone compounds. More particularly, the present invention relates to methods of preventing or treating certain ischemia-related conditions, which may include Alzheimer's disease, Parkinson's disease, and ischemic states that are due to or result from such conditions as: coronary artery bypass graft surgery; global cerebral ischemia due to cardiac arrest; focal cerebral infarction; cerebral hemorrhage; hemorrhage infarction; hypertensive hemorrhage; hemorrhage due to rupture of intracranial vascular abnormalities; subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms; hypertensive encephalopathy; carotid stenosis or occlusion leading to cerebral ischemia; cardiogenic thromboembolism; spinal stroke and spinal cord injury; diseases of cerebral blood vessels, e.g., atherosclerosis, vasculitis; macular degeneration; myocardial infarction; cardiac ischemia; and superaventicular tachyarrhytmia.
摘要翻译： 本发明涉及通过向有需要的患者施用某些缩氨基硫脲化合物来治疗或预防缺血相关（即，神经细胞缺氧和/或降血糖）病症的方法。 更具体地，本发明涉及预防或治疗某些局部缺血相关病症的方法，其可能包括由冠状动脉旁路移植手术引起的或由其导致的阿尔茨海默氏病，帕金森病和缺血状态; 心脏骤停引起的全球脑缺血; 局灶性脑梗死; 脑出血; 出血性梗死; 高血压性出血 出血由于颅内血管异常破裂; 蛛网膜下腔出血由于颅内动脉瘤破裂; 高血压性脑病 颈动脉狭窄或闭塞导致脑缺血; 心源性血栓栓塞 脊髓中风和脊髓损伤; 脑血管疾病，例如动脉粥样硬化，血管炎; 黄斑变性; 心肌梗死; 心脏缺血; 和超表型性快速性心律失常。
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4.发明申请Methods for preventing neural tissue damage and for the treatment of alpha-synuclein diseases 有权预防神经组织损伤和治疗α-突触核蛋白疾病的方法公开(公告)号：US20050032131A1
公开(公告)日：2005-02-10
申请号：US10909116
申请日：2004-07-30
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P25/00 , A61P25/16 , C07K7/04 , C07K7/06 , C07K14/47 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/567
摘要： The present invention relates to drug screening methods and methods of preventing neural tissue damage caused by α-synuclein aggregation. These methods are especially useful in the design and development of inhibitors of Lewy body diseases and other synucleinopathies, and further useful in the treatment of such neurodegenerative diseases, particularly Parkinson's Disease.
摘要翻译： 本发明涉及预防由α-突触核蛋白聚集引起的神经组织损伤的药物筛选方法和方法。 这些方法在路易体疾病和其他突触核蛋白病的抑制剂的设计和开发中特别有用，并且还可用于治疗这种神经变性疾病，特别是帕金森病。
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5.发明申请METHODS OF DIAGNOSING, PREDICTING THERAPEUTIC EFFICACY AND SCREENING FOR NEW THERAPEUTIC AGENTS FOR LEUKEMIA 审中-公开诊断方法，预防治疗效果和筛选新的治疗药物的方法公开(公告)号：US20080124718A1
公开(公告)日：2008-05-29
申请号：US11668421
申请日：2007-01-29
CPC分类号： C12Q1/6886 , C12Q2600/136
摘要： The invention discloses methods for leukemia diagnosis and determining the effectiveness of certain therapies. The methods of the present invention also encompass a way to predict a subject's responsiveness to therapeutic interventions for leukemia, as well as to monitor relapse during treatment due to therapeutic resistance. Further, the methods disclosed can be used to screen for effective therapeutic agents or regimens, either generally or in a specific patient. The invention also provides a unique diagnostic tool for leukemia.
摘要翻译： 本发明公开了用于白血病诊断和确定某些疗法的有效性的方法。 本发明的方法还包括预测受试者对白血病治疗性干预的反应性的方法，以及由于治疗性阻力来监测治疗过程中的复发。 此外，所公开的方法可以用于筛选一般或特定患者中的有效治疗剂或方案。 本发明还提供了用于白血病的独特诊断工具。
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公开(公告)号：US20090275587A1
公开(公告)日：2009-11-05
申请号：US12276456
申请日：2008-11-24
IPC分类号： A61K31/44 , A61P25/00 , A61K31/4965 , A61K31/505 , A61K31/40 , A61K31/4164 , A61K31/42
CPC分类号： A61K31/44 , A61K31/4166 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/4965 , A61K31/505
摘要： The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of the present invention relates to methods of treating specific ischemia-related conditions, including but not limited to Alzheimer's disease, Parkinson's disease, Coronary artery bypass graft surgery, Global cerebral ischemia due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage, hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture of intracranial vascular abnormalities, subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms, hypertensive encephalopathy, carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic thromboembolism, spinal stroke and spinal cord injury, diseases of cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular degeneration, myocardial infarction, cardiac ischemia and superaventicular tachyarrhytmia.
摘要翻译： 本发明涉及通过向需要这种方法的患者施用某些缩氨基硫脲化合物来治疗缺血相关病症的方法。 本发明的优选实施方案涉及治疗特定缺血相关病症的方法，包括但不限于阿尔茨海默氏病，帕金森病，冠状动脉旁路移植手术，由于心脏停搏引起的全球性脑缺血，局灶性脑梗死，脑出血，出血 梗死，高血压性出血。 由于颅内血管异常破裂引起的出血，颅内动脉瘤破裂引起的蛛网膜下腔出血，高血压性脑病，颈动脉狭窄或闭塞，导致脑缺血，心源性血栓栓塞，脊髓卒中和脊髓损伤，脑血管疾病：动脉粥样硬化 ，血管炎，黄斑变性，心肌梗死，心脏缺血和超表型性快速性心律失常。
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公开(公告)号：US07456179B2
公开(公告)日：2008-11-25
申请号：US10835668
申请日：2004-04-30
IPC分类号： A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/4172
CPC分类号： A61K31/44 , A61K31/4166 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/4965 , A61K31/505
摘要： The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of the present invention relates to methods of treating specific ischemia-related conditions, including but not limited to Alzheimer's disease, Parkinson's disease, Coronary artery bypass graft surgery, Global cerebral ischemia due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage, hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture of intracranial vascular abnormalities, subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms, hypertensive encephalopathy, carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic thromboembolism, spinal stroke and spinal cord injury, diseases of cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular degeneration, myocardial infarction, cardiac ischemia and superaventicular tachyarrhytmia.
摘要翻译： 本发明涉及通过向需要这种方法的患者施用某些缩氨基硫脲化合物来治疗缺血相关病症的方法。 本发明的优选实施方案涉及治疗特定缺血相关病症的方法，包括但不限于阿尔茨海默氏病，帕金森病，冠状动脉旁路移植手术，由于心脏停搏引起的全球性脑缺血，局灶性脑梗死，脑出血，出血 梗死，高血压性出血。 由于颅内血管异常破裂引起的出血，颅内动脉瘤破裂引起的蛛网膜下腔出血，高血压性脑病，颈动脉狭窄或闭塞，导致脑缺血，心源性血栓栓塞，脊髓卒中和脊髓损伤，脑血管疾病：动脉粥样硬化 ，血管炎，黄斑变性，心肌梗死，心脏缺血和超表型性快速性心律失常。
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