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    NOVEL TRPA1 ANTAGONISTS
    1.
    发明申请
    NOVEL TRPA1 ANTAGONISTS 有权
    新一代TRPA1 ANTAGONISTS

    公开(公告)号：US20120196894A1

    公开(公告)日：2012-08-02

    申请号：US13499844

    申请日：2010-09-28

    申请人： Mark T. Bilodeau ,  Melissa Egbertson ,  Ahren Green ,  John C. Hartnett ,  Yiwei Li

    发明人： Mark T. Bilodeau ,  Melissa Egbertson ,  Ahren Green ,  John C. Hartnett ,  Yiwei Li

    IPC分类号： A61K31/136 ,  C07D215/38 ,  A61K31/47 ,  C07C255/59 ,  A61K31/4706 ,  C07D311/74 ,  A61K31/352 ,  A61P29/00 ,  C07D215/44 ,  C07C211/48 ,  A61K31/277

    CPC分类号： C07C215/20 ,  A61K31/133 ,  C07C25/02 ,  C07C211/34 ,  C07C215/44 ,  C07C255/58 ,  C07C2602/10 ,  C07D215/38 ,  C07D215/44 ,  C07D311/74 ,  C07D311/76 ,  C07D405/04 ,  C07D405/06

    摘要： The present invention relates to compositions and methods that modulate at least one TRP family member. Specifically, the present invention relates to novel TRPA1 antagonists and their use in the treatment of pain such as chronic inflammatory and neuropathic pain. Compounds that can modulate one or more TRPA1 functions are useful in many aspects including, but not limited to, maintaining calcium homeostasis; maintaining sodium homeostasis; modulating intracellular calcium levels; modulating membrane polarization (membrane potential); modulating cation levels; and/or treating or preventing diseases, disorders, or conditions associated with calcium homeostasis, sodium homeostasis, calcium or sodium dyshomeostasis, or membrane polarization/hyperpolarization (including hypo and hyperexcitability), and/or treating or preventing diseases, disorders, or conditions associated with regulation or misregulation of TRPA1 expression or function. The present invention further relates to methods and compositions that antagonize both a function of TRPA1 and a function of one or more additional TRP channels.

    摘要翻译： 本发明涉及调节至少一种TRP家族成员的组合物和方法。 具体地说，本发明涉及新型TRPA1拮抗剂及其用于治疗慢性炎性和神经性疼痛等疼痛的用途。 可以调节一种或多种TRPA1功能的化合物在许多方面是有用的，包括但不限于维持钙稳态; 维持钠稳态; 调节细胞内钙含量; 调节膜极化（膜电位）; 调节阳离子水平; 和/或治疗或预防与钙稳态相关的疾病，病症或病症，钠稳态，钙或钠血管平衡，或膜极化/超极化（包括低钠和过度兴奋性）和/或治疗或预防与疾病，病症或病症相关 与TRPA1表达或功能调节或失调。 本发明还涉及拮抗TRPA1的功能和一种或多种另外的TRP通道的功能的方法和组合物。

    TRPA1 antagonists
    2.
    发明授权
    TRPA1 antagonists 有权
    TRPA1拮抗剂

    公开(公告)号：US08829196B2

    公开(公告)日：2014-09-09

    申请号：US13499844

    申请日：2010-09-28

    申请人： Mark T. Bilodeau ,  Melissa Egbertson ,  Ahren Green ,  John C. Hartnett ,  Yiwei Li

    发明人： Mark T. Bilodeau ,  Melissa Egbertson ,  Ahren Green ,  John C. Hartnett ,  Yiwei Li

    IPC分类号： C07D215/38 ,  C07C215/20 ,  C07C211/34 ,  C07C25/02 ,  A61K31/133

    CPC分类号： C07C215/20 ,  A61K31/133 ,  C07C25/02 ,  C07C211/34 ,  C07C215/44 ,  C07C255/58 ,  C07C2602/10 ,  C07D215/38 ,  C07D215/44 ,  C07D311/74 ,  C07D311/76 ,  C07D405/04 ,  C07D405/06

    摘要： The present invention relates to compositions and methods that modulate at least one TRP family member. Specifically, the present invention relates to novel TRPA1 antagonists and their use in the treatment of pain such as chronic inflammatory and neuropathic pain. Compounds that can modulate one or more TRPA1 functions are useful in many aspects including, but not limited to, maintaining calcium homeostasis; maintaining sodium homeostasis; modulating intracellular calcium levels; modulating membrane polarization (membrane potential); modulating cation levels; and/or treating or preventing diseases, disorders, or conditions associated with calcium homeostasis, sodium homeostasis, calcium or sodium dyshomeostasis, or membrane polarization/hyperpolarization (including hypo and hyperexcitability), and/or treating or preventing diseases, disorders, or conditions associated with regulation or misregulation of TRPA1 expression or function. The present invention further relates to methods and compositions that antagonize both a function of TRPA1 and a function of one or more additional TRP channels.

    摘要翻译： 本发明涉及调节至少一种TRP家族成员的组合物和方法。 具体地说，本发明涉及新型TRPA1拮抗剂及其用于治疗慢性炎性和神经性疼痛等疼痛的用途。 可以调节一种或多种TRPA1功能的化合物在许多方面是有用的，包括但不限于维持钙稳态; 维持钠稳态; 调节细胞内钙含量; 调节膜极化（膜电位）; 调节阳离子水平; 和/或治疗或预防与钙稳态相关的疾病，病症或病症，钠稳态，钙或钠血管平衡，或膜极化/超极化（包括低钠和过度兴奋性）和/或治疗或预防与疾病，病症或病症相关 与TRPA1表达或功能调节或失调。 本发明还涉及拮抗TRPA1的功能和一种或多种另外的TRP通道的功能的方法和组合物。

    Finding workable virtual I/O mappings for HMC mobile partitions
    8.
    发明授权
    Finding workable virtual I/O mappings for HMC mobile partitions 有权
    为HMC移动分区找到可行的虚拟I / O映射

    公开(公告)号：US08260925B2

    公开(公告)日：2012-09-04

    申请号：US12266916

    申请日：2008-11-07

    申请人： Ping Chen ,  Robert K. Foster ,  Yiwei Li ,  Elizabeth A. Ruth

    发明人： Ping Chen ,  Robert K. Foster ,  Yiwei Li ,  Elizabeth A. Ruth

    IPC分类号： G06F15/173 ,  G06F13/00 ,  G06F9/46

    CPC分类号： G06F9/45558 ,  G06F2009/4557 ,  G06F2009/45579

    摘要： In one embodiment, a data structure stores information about the number of client virtual I/O adapters, the number of possible destination VIOS hosts and the number of available slots on those hosts. The information is used to iteratively assign adapters to available slots of the VIOS hosts of the destination server to which a client partition is to be migrated. A method comprises testing the data structure to determine whether conditions exist that make allocation of the adapter to a VIOS host unquestionable.

    摘要翻译： 在一个实施例中，数据结构存储关于客户端虚拟I / O适配器的数量，可能的目的地VIOS主机的数量和这些主机上的可用时隙数量的信息。 该信息用于迭代地将适配器分配给要迁移客户端分区的目标服务器的VIOS主机的可用插槽。 一种方法包括测试数据结构以确定是否存在将适配器分配给VIOS主机的条件是不容置疑的。

    FINDING WORKABLE VIRTUAL I/O MAPPINGS FOR HMC MOBILE PARTITIONS
    10.
    发明申请
    FINDING WORKABLE VIRTUAL I/O MAPPINGS FOR HMC MOBILE PARTITIONS 有权
    为HMC移动分组找到可工作的虚拟I / O映射

    公开(公告)号：US20100122124A1

    公开(公告)日：2010-05-13

    申请号：US12266916

    申请日：2008-11-07

    申请人： Ping Chen ,  Robert K. Foster ,  Yiwei Li ,  Elizabeth A. Ruth

    发明人： Ping Chen ,  Robert K. Foster ,  Yiwei Li ,  Elizabeth A. Ruth

    IPC分类号： G06F9/455 ,  G06F11/07

    CPC分类号： G06F9/45558 ,  G06F2009/4557 ,  G06F2009/45579

    摘要： In one embodiment, a data structure stores information about the number of client virtual I/O adapters, the number of possible destination VIOS hosts and the number of available slots on those hosts. The information is used to iteratively assign adapters to available slots of the VIOS hosts of the destination server to which a client partition is to be migrated. A method comprises testing the data structure to determine whether conditions exist that make allocation of the adapter to a VIOS host unquestionable.

    摘要翻译： 在一个实施例中，数据结构存储关于客户端虚拟I / O适配器的数量，可能的目的地VIOS主机的数量和这些主机上的可用时隙数量的信息。 该信息用于迭代地将适配器分配给要迁移客户端分区的目标服务器的VIOS主机的可用插槽。 一种方法包括测试数据结构以确定是否存在将适配器分配给VIOS主机的条件是不容置疑的。