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公开(公告)号：US08642513B2
公开(公告)日：2014-02-04
申请号：US11990974
申请日：2006-09-14
IPC分类号： C07K16/00
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/1018 , C07K16/1275 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C40B40/02
摘要： The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
摘要翻译： 本发明涉及免疫球蛋白文库的产生以及鉴定和产生具有特定功能的免疫球蛋白。
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2.发明授权Human binding molecules having killing activity against enterococci and uses thereof 有权具有针对肠球菌的杀伤活性的人结合分子及其用途公开(公告)号：US07960518B2
公开(公告)日：2011-06-14
申请号：US12227116
申请日：2007-06-05
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 本发明提供了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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公开(公告)号：US20090054254A1
公开(公告)日：2009-02-26
申请号：US11990974
申请日：2006-09-14
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/1018 , C07K16/1275 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C40B40/02
摘要： The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
摘要翻译： 本发明涉及免疫球蛋白文库的产生以及鉴定和产生具有特定功能的免疫球蛋白。
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4.发明申请HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA VIRUS H5N1 AND USES THEREOF 有权能够中和流感病毒H5N1的人结合分子及其用途公开(公告)号：US20120276115A1
公开(公告)日：2012-11-01
申请号：US13458964
申请日：2012-04-27
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译： 描述了结合分子，例如结合流感病毒H5N1的人单克隆抗体，并具有针对流感病毒H5N1的中和活性。 还描述了编码抗体的核酸分子和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。 在某些实施方案中，抗体在体内提供跨亚型保护，使得可以预防和/或治疗H5，H2，H6，H9和H1基于流感亚型的感染。
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5.发明申请HUMAN BINDING MOLECULES HAVING KILLING ACTIVITY AGAINST STAPHYLOCOCCI AND USES THEREOF 有权具有杀伤生物活性的人结合分子及其用途公开(公告)号：US20120141493A1
公开(公告)日：2012-06-07
申请号：US13397606
申请日：2012-02-15
IPC分类号： A61K39/40 , C12P21/08 , A61P31/04 , C12N5/10 , C07H21/04 , C12N1/15 , C12N1/19 , C12N15/63 , C07K16/00 , G01N33/53 , C12N1/21
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
摘要： Described are human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Staphylococcus.
摘要翻译： 描述了特异性结合葡萄球菌并具有针对葡萄球菌的杀伤活性，编码人结合分子的核酸分子，包含人结合分子的组合物和鉴定或产生人结合分子的方法的人结合分子。 人结合分子可用于诊断，预防和/或治疗由葡萄球菌产生的病症。
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公开(公告)号：US20120093823A1
公开(公告)日：2012-04-19
申请号：US13315475
申请日：2011-12-09
IPC分类号： A61K39/395 , C07K16/10 , A61P31/16 , C07H21/04
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
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7.发明授权Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof 有权能够中和流感病毒H5N1的人结合分子及其用途公开(公告)号：US08691223B2
公开(公告)日：2014-04-08
申请号：US13315475
申请日：2011-12-09
IPC分类号： A61K39/395 , A61K39/42 , C12N7/00
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译： 描述了结合分子，例如结合流感病毒H5N1的人单克隆抗体，并具有针对流感病毒H5N1的中和活性。 还描述了编码抗体的核酸分子和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。 在某些实施方案中，抗体在体内提供跨亚型保护，使得可以预防和/或治疗H5，H2，H6，H9和H1基于流感亚型的感染。
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8.发明授权Human binding molecules having killing activity against staphylococci and uses thereof 有权具有针对葡萄球菌的杀伤活性的人结合分子及其用途公开(公告)号：US08211431B2
公开(公告)日：2012-07-03
申请号：US12227029
申请日：2007-06-05
IPC分类号： A61K39/40
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
摘要： The present invention provides human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Staphylococcus.
摘要翻译： 本发明提供与葡萄球菌特异性结合并具有针对葡萄球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由葡萄球菌产生的病症。
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9.发明授权Host cell specific binding molecules capable of neutralizing viruses and uses thereof 有权能够中和病毒的宿主细胞特异性结合分子及其用途公开(公告)号：US08052974B2
公开(公告)日：2011-11-08
申请号：US11919265
申请日：2006-05-11
CPC分类号： C07K16/1081 , Y02A50/394
摘要： The present invention provides human binding molecules specifically binding to a host cell protein and having virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of viral infections.
摘要翻译： 本发明提供与宿主细胞蛋白特异性结合并具有病毒中和活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于病毒感染的诊断，预防和/或治疗。
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10.发明申请Host cell specific binding molecules capable of neutralizing viruses and uses thereof 有权能够中和病毒的宿主细胞特异性结合分子及其用途公开(公告)号：US20100303801A1
公开(公告)日：2010-12-02
申请号：US11919265
申请日：2006-05-11
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , A61P31/14
CPC分类号： C07K16/1081 , Y02A50/394
摘要： The present invention provides human binding molecules specifically binding to a host cell protein and having virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of viral infections.
摘要翻译： 本发明提供与宿主细胞蛋白特异性结合并具有病毒中和活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于病毒感染的诊断，预防和/或治疗。
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