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1.发明授权Human binding molecules having killing activity against enterococci and uses thereof 有权具有针对肠球菌的杀伤活性的人结合分子及其用途公开(公告)号：US07960518B2
公开(公告)日：2011-06-14
申请号：US12227116
申请日：2007-06-05
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 本发明提供了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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2.发明申请HUMAN BINDING MOLECULES HAVING KILLING ACTIVITY AGAINST ENTEROCOCCI AND USES THEREOF 有权具有杀伤活性的人类结合分子及其用途公开(公告)号：US20120315278A1
公开(公告)日：2012-12-13
申请号：US13550100
申请日：2012-07-16
IPC分类号： C07K16/12 , C12N15/63 , C12N1/21 , A61P31/04 , C12N5/10 , C12P21/08 , A61K39/40 , G01N33/577 , C12N15/13 , C12N1/19
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 描述了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 该分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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3.发明申请Human binding molecules having killing activity against enterococci and uses thereof 有权具有针对肠球菌的杀伤活性的人结合分子及其用途公开(公告)号：US20110268739A1
公开(公告)日：2011-11-03
申请号：US13068784
申请日：2011-05-19
IPC分类号： C07K16/12 , C12N15/85 , C12N15/80 , C12N15/81 , C12N1/21 , A61P31/04 , C12N1/15 , C12N5/10 , C12P21/08 , A61K39/395 , G01N33/569 , C12N15/13 , C12N1/19
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 描述了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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4.发明申请Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof 有权具有针对肠球菌的杀伤活性的人类结合分子及其用途公开(公告)号：US20090169562A1
公开(公告)日：2009-07-02
申请号：US12227116
申请日：2007-06-05
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 本发明提供了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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公开(公告)号：US08628776B2
公开(公告)日：2014-01-14
申请号：US13550100
申请日：2012-07-16
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 描述了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 该分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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6.发明授权Human binding molecules having killing activity against enterococci and uses thereof 有权具有针对肠球菌的杀伤活性的人结合分子及其用途公开(公告)号：US08241631B2
公开(公告)日：2012-08-14
申请号：US13068784
申请日：2011-05-19
IPC分类号： A61K39/395
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 描述了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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公开(公告)号：US08642513B2
公开(公告)日：2014-02-04
申请号：US11990974
申请日：2006-09-14
IPC分类号： C07K16/00
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/1018 , C07K16/1275 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C40B40/02
摘要： The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
摘要翻译： 本发明涉及免疫球蛋白文库的产生以及鉴定和产生具有特定功能的免疫球蛋白。
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公开(公告)号：US20090054254A1
公开(公告)日：2009-02-26
申请号：US11990974
申请日：2006-09-14
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/1018 , C07K16/1275 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C40B40/02
摘要： The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
摘要翻译： 本发明涉及免疫球蛋白文库的产生以及鉴定和产生具有特定功能的免疫球蛋白。
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9.发明申请HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA VIRUS H5N1 AND USES THEREOF 有权能够中和流感病毒H5N1的人结合分子及其用途公开(公告)号：US20120276115A1
公开(公告)日：2012-11-01
申请号：US13458964
申请日：2012-04-27
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译： 描述了结合分子，例如结合流感病毒H5N1的人单克隆抗体，并具有针对流感病毒H5N1的中和活性。 还描述了编码抗体的核酸分子和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。 在某些实施方案中，抗体在体内提供跨亚型保护，使得可以预防和/或治疗H5，H2，H6，H9和H1基于流感亚型的感染。
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10.发明申请HUMAN BINDING MOLECULES HAVING KILLING ACTIVITY AGAINST STAPHYLOCOCCI AND USES THEREOF 有权具有杀伤生物活性的人结合分子及其用途公开(公告)号：US20120141493A1
公开(公告)日：2012-06-07
申请号：US13397606
申请日：2012-02-15
IPC分类号： A61K39/40 , C12P21/08 , A61P31/04 , C12N5/10 , C07H21/04 , C12N1/15 , C12N1/19 , C12N15/63 , C07K16/00 , G01N33/53 , C12N1/21
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
摘要： Described are human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Staphylococcus.
摘要翻译： 描述了特异性结合葡萄球菌并具有针对葡萄球菌的杀伤活性，编码人结合分子的核酸分子，包含人结合分子的组合物和鉴定或产生人结合分子的方法的人结合分子。 人结合分子可用于诊断，预防和/或治疗由葡萄球菌产生的病症。
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