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    INTRAMEDULLARY FIXATION ASSEMBLY AND DEVICES AND METHODS FOR INSTALLING THE SAME
    1.
    发明申请
    INTRAMEDULLARY FIXATION ASSEMBLY AND DEVICES AND METHODS FOR INSTALLING THE SAME 审中-公开
    内置式固定装置及其装置及其安装方法

    公开(公告)号：US20080091203A1

    公开(公告)日：2008-04-17

    申请号：US11948189

    申请日：2007-11-30

    申请人： Mark Warburton ,  Robert Fencl ,  John Capo ,  Virak Tan ,  Aaron Smith

    发明人： Mark Warburton ,  Robert Fencl ,  John Capo ,  Virak Tan ,  Aaron Smith

    IPC分类号： A61B17/58 ,  A61B17/56

    CPC分类号： A61B17/1725 ,  A61B17/1659 ,  A61B17/1668 ,  A61B17/1684 ,  A61B17/72 ,  A61B17/848 ,  A61B17/861 ,  A61B17/8875 ,  A61B2017/0046 ,  A61B2017/922 ,  A61B2090/062

    摘要： An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

    摘要翻译： 可用于不同长骨类型的髓内固定组件和用于引导髓内固定组件的部署的引导组件。 髓内固定组件包括具有端部的固定构件和在端部之间延伸的弯曲体。 固定构件的弯曲体具有构造成延伸穿过髓管的曲率半径，而不管长骨解剖结构如何。 紧固件将固定构件固定在骨碎片上并由导向组件引导。 引导组件包括引导体，该引导体限定了被构造成引导紧固件通过限定在固定构件中的开口并进入骨碎片的开口。 引导体的固定端包括一对相对的会聚表面，其被配置成与通过第一片段中的侧孔可接近的固定构件的暴露端以正配合接合。

    Intramedullary fixation assembly and devices and methods for installing the same
    2.
    发明申请
    Intramedullary fixation assembly and devices and methods for installing the same 审中-公开
    髓内固定组装及其安装方法

    公开(公告)号：US20060015101A1

    公开(公告)日：2006-01-19

    申请号：US10891737

    申请日：2004-07-15

    申请人： Mark Warburton ,  Robert Fencl ,  John Capo ,  Virak Tan ,  Aaron Smith

    发明人： Mark Warburton ,  Robert Fencl ,  John Capo ,  Virak Tan ,  Aaron Smith

    IPC分类号： A61F2/30

    CPC分类号： A61B17/1725 ,  A61B17/1659 ,  A61B17/1668 ,  A61B17/1684 ,  A61B17/72 ,  A61B17/848 ,  A61B17/861 ,  A61B17/8875 ,  A61B2017/0046 ,  A61B2017/922 ,  A61B2090/062

    摘要： An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

    摘要翻译： 可用于不同长骨类型的髓内固定组件和用于引导髓内固定组件的部署的引导组件。 髓内固定组件包括具有端部的固定构件和在端部之间延伸的弯曲体。 固定构件的弯曲体具有构造成延伸穿过髓管的曲率半径，而不管长骨解剖结构如何。 紧固件将固定构件固定在骨碎片上并由导向组件引导。 引导组件包括引导体，该引导体限定了被构造成引导紧固件通过限定在固定构件中的开口并进入骨碎片的开口。 引导体的固定端包括一对相对的会聚表面，其被配置成与通过第一片段中的侧孔可接近的固定构件的暴露端以正配合接合。

    Methods of Treating Microbial Infections
    6.
    发明申请
    Methods of Treating Microbial Infections 失效
    治疗微生物感染的方法

    公开(公告)号：US20070003590A1

    公开(公告)日：2007-01-04

    申请号：US11420826

    申请日：2006-05-30

    申请人： Mark Warburton

    发明人： Mark Warburton

    IPC分类号： A61K31/695 ,  A61K31/555 ,  A61K31/522 ,  A61K9/22

    CPC分类号： A61K31/522 ,  A61K9/12 ,  A61K31/555 ,  A61K31/695 ,  Y02A50/475

    摘要： The present invention provides methods of treating microbacterial infections comprising administering to a subject in need thereof, a composition comprising a compound of formula I: wherein: X1, X2 and X3 are selected from the group consisting of oxygen, sulfur, aminoalkyl, alkoxy, aryl, and heteroaryl, unsubstituted or substituted; and R1, R2, R3 and R4 are selected from the group consisting of hydrogen, actinium, silicon, germanium, cyano, alkyl, alkoxy, allyl, alkenyl, alkynyl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkene, alkyne, aryl, halide, alkylhalide, alkyloxyalkyl, thioalkyl, alkylthioalkyl, alkylamino, cycloalkyl, heterocyclyl, unsubstituted or substituted; or a pharmaceutically acceptable salt thereof. The present invention further provides methods of treating bacterial infections comprising administering to a subject in need thereof, an effective amount of a pharmaceutical composition comprising uric acid, urate, derivatives thereof, salts and hydrates thereof and prodrugs thereof and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供了治疗微细菌感染的方法，其包括向有需要的受试者施用包含式I化合物的组合物：其中：X 1，X 2和X 2 SO 3选自氧，硫，氨基烷基，烷氧基，芳基和杂芳基，未取代或取代的; 和R 1，R 2，R 3和R 4选自氢，锕 ，硅，锗，氰基，烷基，烷氧基，烯丙基，烯基，炔基，烷基芳基，芳基烷基，氨基烷基，烷基氨基，烯烃，炔，芳基，卤化物，烷基卤，烷氧基烷基，硫代烷基，烷硫基烷基，烷基氨基，环烷基，杂环基，未取代或取代 ; 或其药学上可接受的盐。 本发明进一步提供治疗细菌感染的方法，包括向有需要的受试者施用有效量的包含尿酸，尿酸盐，其衍生物，其盐和水合物及其前药和药学上可接受的载体的药物组合物。