-
公开(公告)号：US20060130170A1
公开(公告)日：2006-06-15
申请号：US10733042
申请日：2003-12-11
申请人： Markley Leavitt , Jeff Rapp , Robert Ivarie , Arthur Karnuah
发明人： Markley Leavitt , Jeff Rapp , Robert Ivarie , Arthur Karnuah
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , C07K16/00 , C07K2317/11 , C07K2317/21 , C12N2799/02 , C12N2800/10 , C12N2800/204 , C12N2800/206 , C12N2830/90
摘要： The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional regulatory region. The isolated nucleic acid of the present invention is useful for reducing chromosomal positional effects upon the transcription of a transgene operably linked to the ovalbumin transcriptional regulatory region and transfected into a recipient avian cell The recombinant nucleic cid molecules of the present invention may further comprise a polyadenylation signal sequence or an avian 3′ domain, and optionally, an internal ribosome entry site for expression of an operably linked heterologous nucleic acid insert in a transfected avian cell.
摘要翻译： 本发明提供分离和重组的禽类核酸分子，其包含至少一种禽类MAR和编码卵白蛋白转录调节区的禽类核酸序列。 本发明的分离的核酸可用于降低可操作地连接到卵白蛋白转录调节区并转染入受体禽类细胞的转基因的转录中的染色体位置效应。本发明的重组核酸分子还可以包含多聚腺苷酸化 信号序列或鸟类3'结构域，以及任选的内部核糖体进入位点，用于在转染的禽类细胞中表达可操作地连接的异源核酸插入物。
-
公开(公告)号：US20060286638A1
公开(公告)日：2006-12-21
申请号：US11454399
申请日：2006-06-16
申请人： Jeffrey Rapp , Stephen Parker , Markley Leavitt , Dawn Eberhardt , Leandro Christmann , Alex Harvey
发明人： Jeffrey Rapp , Stephen Parker , Markley Leavitt , Dawn Eberhardt , Leandro Christmann , Alex Harvey
CPC分类号： C12P21/02
摘要： The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
摘要翻译： 本发明涉及可以在培养物中传代的细胞，并且可以用于促进剂测定和异源蛋白质的生产。
-
公开(公告)号：US20060046247A1
公开(公告)日：2006-03-02
申请号：US10926707
申请日：2004-08-25
申请人： Jeffrey Rapp , Markley Leavitt , Robin Morgan
发明人： Jeffrey Rapp , Markley Leavitt , Robin Morgan
CPC分类号： A01K67/0275 , A01K2227/30 , A01K2267/02 , A61K48/00 , A61K48/005 , C12N2710/16322
摘要： The invention relates to nucleotide sequences which encode therapeutic polynucleotides which correspond to one or more certain sequences in the genome of an avian pathogen. The invention also relates to transgenic avians whose cells contain such nucleotide sequences.
摘要翻译： 本发明涉及编码对应于禽类病原体基因组中的一个或多个特定序列的治疗性多核苷酸的核苷酸序列。 本发明还涉及其细胞含有这种核苷酸序列的转基因鸟类。
-
公开(公告)号：US20050273873A1
公开(公告)日：2005-12-08
申请号：US11193750
申请日：2005-07-29
IPC分类号： A01K67/027 , C12N5/06 , C12N15/85
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2227/30 , A01K2267/01 , C12N2800/204 , C12N2800/30 , C12N2830/008 , C12N2830/40 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： The invention includes transchromosomal avians and transchromosomal avian cells and methods for the introduction of artificial chromosomes into the genome of avians and avian cells.
-
公开(公告)号：US20050176047A1
公开(公告)日：2005-08-11
申请号：US11047184
申请日：2005-01-31
申请人： Alex Harvey , Markley Leavitt , Youliang Wang
发明人： Alex Harvey , Markley Leavitt , Youliang Wang
CPC分类号： C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要： The present invention includes avian ovomucoid gene expression controlling regions which may be operably linked to one or more useful amino acid coding sequences.
摘要翻译： 本发明包括可以与一个或多个有用的氨基酸编码序列可操作地连接的鸟类卵类粘蛋白基因表达控制区。
-
公开(公告)号：US20060123504A1
公开(公告)日：2006-06-08
申请号：US11296119
申请日：2005-12-07
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/40 , A01K2267/01 , C12N15/8509
摘要： The invention includes transgenic avians which produce eggs containing human polyclonal antibody and methods of making such avians.
摘要翻译： 本发明包括产生含有人多克隆抗体的卵的转基因鸟类和制造这种鸟类的方法。
-
公开(公告)号：US20050003414A1
公开(公告)日：2005-01-06
申请号：US10856218
申请日：2004-05-28
申请人： Alex Harvey , Markley Leavitt , Youliang Wang
发明人： Alex Harvey , Markley Leavitt , Youliang Wang
IPC分类号： A01K67/027 , C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/30 , A01K2267/01 , C07K2317/732 , C07K2317/734 , C12N15/8509 , C12N2800/204 , C12N2830/008 , C12N2830/90
摘要： The present invention includes nucleic acid molecules comprising an artificial chromosome and an avian ovomucoid gene expression controlling region operably linked to the coding sequence of a useful polypeptide.
摘要翻译： 本发明包括核酸分子，其包含可操作地连接到有用多肽的编码序列的人造染色体和禽类卵巢粘蛋白基因表达控制区。
-
公开(公告)号：US20070113299A1
公开(公告)日：2007-05-17
申请号：US11649543
申请日：2007-01-04
申请人： Alex Harvey , Markley Leavitt , Youliang Wang
发明人： Alex Harvey , Markley Leavitt , Youliang Wang
IPC分类号： A01K67/027 , C07H21/04 , C12N5/06
CPC分类号： C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要： Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译： 具有与一个或多个有用的氨基酸编码序列可操作地连接的重组卵巢粘蛋白基因表达控制区的转基因鸟类。
-
公开(公告)号：US20060174364A1
公开(公告)日：2006-08-03
申请号：US11362064
申请日：2006-02-24
IPC分类号： A01K67/027 , C12N15/87
CPC分类号： C12N9/22 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2227/40 , A01K2267/01 , C12N15/8509 , C12N15/873 , C12N2800/20 , C12N2800/204 , C12N2800/206 , C12N2830/00 , C12N2830/40 , C12N2830/90 , C12N2840/203
摘要： The invention includes avians containing an artificial chromosome in their genome and methods of making the avians.
-
公开(公告)号：US20060159658A1
公开(公告)日：2006-07-20
申请号：US11335375
申请日：2006-01-19
申请人： Yashwant Deo , Stephen Parker , Markley Leavitt
发明人： Yashwant Deo , Stephen Parker , Markley Leavitt
IPC分类号： A61K38/21
CPC分类号： A61K38/212 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： This invention includes methods for treating conditions with pharmaceutical compositions that comprise glycosylated interferon alpha. Pharmaceutical compositions that can be employed in the present invention include glycosylated interferon alpha 2 species in combination with pharmaceutical carriers, pharmaceutical excipients and/or other agents.
摘要翻译： 本发明包括用包含糖基化干扰素α的药物组合物治疗病症的方法。 可用于本发明的药物组合物包括与药物载体，药用赋形剂和/或其它试剂组合的糖基化干扰素α2物质。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.036 秒)
