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公开(公告)号:US20100310552A1
公开(公告)日:2010-12-09
申请号:US12799282
申请日:2010-04-21
IPC分类号: C12N15/877 , C12P21/00 , C07K16/02 , A61K39/395
CPC分类号: C07K16/00 , A01K67/0275 , A01K2207/15 , A01K2217/052 , A01K2217/206 , A01K2227/30 , A01K2267/01 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/8135 , C07K2317/11 , C07K2317/23 , C07K2317/92 , C12N9/2462 , C12N9/86 , C12N15/85 , C12N15/8509 , C12N15/87 , C12N2799/027 , C12N2830/15 , C12N2830/90 , C12N2840/203
摘要: The invention relates to transgenic avians which produce antibodies in the egg white by introducing a nucleic acid sequence into the genome of an avian embryo wherein the nucleic acid sequence comprises a nucleotide sequence encoding an antibody and to the antibodies and to methods related thereto.
摘要翻译: 本发明涉及通过将核酸序列引入禽胚胎的基因组中而产生蛋清中的抗体的转基因鸟类,其中所述核酸序列包含编码抗体的核苷酸序列和与抗体相关的方法。
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公开(公告)号:US20080222743A1
公开(公告)日:2008-09-11
申请号:US11799253
申请日:2007-05-01
IPC分类号: C12N15/87 , A01K67/027
CPC分类号: C12N15/1133 , A01K67/0275 , A01K2217/058 , A01K2227/30 , A01K2267/02 , A01K2267/0337 , C12N15/1131 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2799/027
摘要: The invention relates to transgenic avians whose genome contains nucleotide sequences which encode therapeutic polynucleotides that correspond to one or more certain sequences in the genome of an avian pathogen.
摘要翻译: 本发明涉及转基因鸟类,其基因组包含编码对应于禽类病原体基因组中的一个或多个特定序列的治疗性多核苷酸的核苷酸序列。
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公开(公告)号:US20060286638A1
公开(公告)日:2006-12-21
申请号:US11454399
申请日:2006-06-16
申请人: Jeffrey Rapp , Stephen Parker , Markley Leavitt , Dawn Eberhardt , Leandro Christmann , Alex Harvey
发明人: Jeffrey Rapp , Stephen Parker , Markley Leavitt , Dawn Eberhardt , Leandro Christmann , Alex Harvey
CPC分类号: C12P21/02
摘要: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
摘要翻译: 本发明涉及可以在培养物中传代的细胞,并且可以用于促进剂测定和异源蛋白质的生产。
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公开(公告)号:US20060166260A1
公开(公告)日:2006-07-27
申请号:US11392176
申请日:2006-03-29
申请人: Leandro Christmann
发明人: Leandro Christmann
IPC分类号: C12Q1/68 , A01K67/027
CPC分类号: C12N15/8509 , A01K67/0273 , A01K2217/05 , A01K2217/075 , A01K2227/30 , A01K2267/01 , A01K2267/02 , C07K14/005 , C12N2770/24222
摘要: The invention includes methods of visualizing and manipulating avian eggs employing TPLSM.
摘要翻译: 本发明包括使用TPLSM可视化和操纵禽蛋的方法。
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公开(公告)号:US07432103B2
公开(公告)日:2008-10-07
申请号:US12012387
申请日:2008-02-01
申请人: Jeffrey C. Rapp , Stephen H. Parker , Markley C. Leavitt , Dawn M. Eberhardt , Leandro Christmann , Alex J. Harvey
发明人: Jeffrey C. Rapp , Stephen H. Parker , Markley C. Leavitt , Dawn M. Eberhardt , Leandro Christmann , Alex J. Harvey
CPC分类号: C12P21/02
摘要: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
摘要翻译: 本发明涉及可以在培养物中传代的细胞,并且可以用于促进剂测定和异源蛋白质的生产。
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公开(公告)号:US07339090B2
公开(公告)日:2008-03-04
申请号:US11159973
申请日:2005-06-23
申请人: Leandro Christmann
发明人: Leandro Christmann
IPC分类号: A01K67/027 , C12N15/00 , A61M1/00 , A61M5/00
CPC分类号: A01K67/0275 , A01K2217/05 , A61M37/00 , C12M35/00 , G02B21/32
摘要: The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides magnified viewing of an object to an operator from an angle other than a right angle to the object.
摘要翻译: 本发明提供了一种显微注射装置,其包括针和观察仪器,其中观察仪器从与该物体的直角不同的角度向操作者提供物体的放大观察。
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公开(公告)号:US07312374B2
公开(公告)日:2007-12-25
申请号:US10251364
申请日:2002-09-18
IPC分类号: C12N15/00 , A01K67/027
CPC分类号: A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2227/30 , A01K2267/01 , C07K16/00 , C07K2317/20 , C07K2317/23 , C12N15/8509 , C12N2799/027 , C12N2800/30 , C12N2830/008 , C12N2830/15 , C12N2830/46 , C12N2830/90 , C12N2840/203
摘要: This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.
摘要翻译: 本发明提供了将异源编码序列稳定引入鸟的基因组并表达编码序列以产生所需蛋白质或改变鸟的表型的方法。 本发明提供了通过细胞质显微注射将转基因导入禽胚胎细胞的细胞质的优选方法。 然后胚胎发育成能够表达异源蛋白质和/或能够通过育种产生一系列转基因鸟类的转基因成体。 本发明还提供了可用于该方法的合成载体和基因启动子,以及表达异源蛋白质和含有异源蛋白质的禽卵的转基因鸟类。
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公开(公告)号:US20050273873A1
公开(公告)日:2005-12-08
申请号:US11193750
申请日:2005-07-29
IPC分类号: A01K67/027 , C12N5/06 , C12N15/85
CPC分类号: C12N15/8509 , A01K67/0275 , A01K2227/30 , A01K2267/01 , C12N2800/204 , C12N2800/30 , C12N2830/008 , C12N2830/40 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要: The invention includes transchromosomal avians and transchromosomal avian cells and methods for the introduction of artificial chromosomes into the genome of avians and avian cells.
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公开(公告)号:US07795496B2
公开(公告)日:2010-09-14
申请号:US12378304
申请日:2009-02-13
IPC分类号: C12N15/00 , A01K67/027
CPC分类号: C12N15/87 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/02 , C12N15/8509 , C12N2800/30
摘要: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
摘要翻译: 本发明提供了生产转基因鸟类的方法,其可以包括将异源核酸递送到禽类的输卵管组织,其中核酸进入输卵管组织的细胞并被表达。
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公开(公告)号:US20090193534A1
公开(公告)日:2009-07-30
申请号:US12378304
申请日:2009-02-13
IPC分类号: C12N15/12 , A61K31/711
CPC分类号: C12N15/87 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/02 , C12N15/8509 , C12N2800/30
摘要: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
摘要翻译: 本发明提供了生产转基因鸟类的方法,其可以包括将异源核酸递送到禽类的输卵管组织,其中核酸进入输卵管组织的细胞并被表达。
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