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1.发明申请New effector conjugates, process for their production and their pharmaceutical use 审中-公开新的效应物缀合物，其生产过程及其药物用途公开(公告)号：US20080166362A1
公开(公告)日：2008-07-10
申请号：US12000258
申请日：2007-12-11
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： A61K39/395 , C07D417/00 , C07K16/00 , A61P25/00 , A61K35/04 , A61P19/00 , A61P29/00 , A61K31/425
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译： 描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。 它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。 描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。
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2.发明授权Effector conjugates, process for their production and their pharmaceutical use 失效效应物缀合物，其制备方法及其药物用途公开(公告)号：US07335775B2
公开(公告)日：2008-02-26
申请号：US11509557
申请日：2006-08-25
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： C07D277/20 , C07D417/08
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译： 描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。 它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。 描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。
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3.发明申请New effector conjugates, process for their production and their pharmaceutical use 失效新的效应物缀合物，其生产过程及其药物用途公开(公告)号：US20050026971A1
公开(公告)日：2005-02-03
申请号：US10631011
申请日：2003-07-31
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： A61K47/48 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , C07D493/04 , A61K31/427 , C07D417/02
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译： 描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。 它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。 描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。
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4.发明申请New effector conjugates, process for their production and their pharmaceutical use 失效新的效应物缀合物，其生产过程及其药物用途公开(公告)号：US20070088060A1
公开(公告)日：2007-04-19
申请号：US11509557
申请日：2006-08-25
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： A61K31/427
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译： 描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。 它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。 描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。
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5.发明授权Effector conjugates, process for their production and their pharmaceutical use 失效效应物缀合物，其制备方法及其药物用途公开(公告)号：US07129254B2
公开(公告)日：2006-10-31
申请号：US10631011
申请日：2003-07-31
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： A61K31/425 , A61K31/44 , C07D277/20 , C07D417/08
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译： 描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。 它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。 描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。
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公开(公告)号：US20090137002A1
公开(公告)日：2009-05-28
申请号：US12182235
申请日：2008-07-30
申请人： Heike PETRUL , Andreas Menrad , Jorg Willuda , Dieter Zopf , Jens Glienke , Josef Prassler , Andreas Popp , Stefan Steidl , Catrin Pracht
发明人： Heike PETRUL , Andreas Menrad , Jorg Willuda , Dieter Zopf , Jens Glienke , Josef Prassler , Andreas Popp , Stefan Steidl , Catrin Pracht
CPC分类号： C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.
摘要翻译： 本发明涉及抗体和抗体片段，特异性识别包含轻链和轻链的重链和轻链的EphB4受体及其作为用于治疗病理性血管发生，特别是癌症治疗的药物的用途。
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7.发明申请NOVEL METHOD FOR THE STABILIZATION OF CHIMERIC IMMUNOGLOBULIN OR IMMUNOGLOBULIN FRAGMENTS AND, AND STABILIZED ANTI-EGP-2 SCFV FRAGMENT 有权用于稳定免疫球蛋白或免疫球蛋白片段的新方法和稳定的抗EGP-2 SCFV片段公开(公告)号：US20080299124A1
公开(公告)日：2008-12-04
申请号：US11969059
申请日：2008-01-03
IPC分类号： A61K39/395 , C07K16/18 , A61P31/00
CPC分类号： C07K16/00 , A61K47/6813 , A61K47/6819 , A61K47/6821 , A61K47/6823 , A61K47/6825 , A61K47/6829 , A61K47/6851 , A61K47/6877 , A61K51/1045 , A61K51/1087 , A61K2039/505 , C07K16/06 , C07K16/28 , C07K16/30 , C07K16/465 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
摘要翻译： 本发明涉及稳定嵌合免疫球蛋白或免疫球蛋白片段的方法。 此外，本发明还提供了稳定的抗EGP-2 scFv片段。
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公开(公告)号：US20060159683A1
公开(公告)日：2006-07-20
申请号：US11024877
申请日：2004-12-30
IPC分类号： A61K39/395 , C07K16/30 , G01N33/574
CPC分类号： C07K16/00 , A61K47/6813 , A61K47/6819 , A61K47/6821 , A61K47/6823 , A61K47/6825 , A61K47/6829 , A61K47/6851 , A61K47/6877 , A61K51/1045 , A61K51/1087 , A61K2039/505 , C07K16/06 , C07K16/28 , C07K16/30 , C07K16/465 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
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